Aim of the study: Evaluate posture and quality of life in children with hemiparesis and assess the relation between them. Study Design: the observational-cross-sectional study was conducted in the National Institute of Neuromotor System in Giza Governorate. Subjects & Methods: Sixty children with hemiparesis cerebral palsy, 28 girls and 32 boys whose ages ranged from 6 to 10 years old, participated in this study. The Postural assessment software (PAS/SAPO) was used to assess their body posture from digitalized pictures (anterior, posterior, right, and left lateral views). The quality of life of participating children was evaluated through the Pediatric Quality of Life Inventory Version 4.0 (PedsQL 4.0). All statistical measures were carried out using the statistical SPSS package program. Results: Postural deviations of children with hemiparesis were characterized by the asymmetry of acromions, anterior superior iliac spine (ASIS), and scapula alignments from the anterior and posterior view. It also adopted head, trunk, and knee flexion and reduced ankle angle from lateral views. There was a decrease in PedsQL 4.0 scores (all domains and the total score).