A study of the bioactivity, hemocompatibility and antimicrobial properties of a zinc oxide and calcium phosphate composite for bone regeneration

Barbosa, Amanda Alves; Júnior, Severino Alves; Ferraz, Andréa de Vasconcelos

doi:10.1590/0366-69132023693903396

Cited by 1 publication

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“…Osx is a human protein encoded by the SP7 [43]. It is a member of the zinc finger transcription factor Sp family and is highly conserved in osteogenic vertebrate species [44]. Sp7 plays a crucial role in driving bone formation along with Runx2 and distal-less homeobox (Dlx5) [45].…”

Section: Discussionmentioning

confidence: 99%

Exploring the Osteogenic Potential of Zinc-Doped Magnesium Phosphate Cement (ZMPC): A Novel Material for Orthopedic Bone Defect Repair

Liu,

Yu,

Chen

et al. 2024

Biomedicines

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In orthopedics, the repair of bone defects remains challenging. In previous research reports, magnesium phosphate cements (MPCs) were widely used because of their excellent mechanical properties, which have been widely used in the field of orthopedic medicine. We built a new k-struvite (MPC) cement obtained from zinc oxide (ZnO) and assessed its osteogenic properties. Zinc-doped magnesium phosphate cement (ZMPC) is a novel material with good biocompatibility and degradability. This article summarizes the preparation method, physicochemical properties, and biological properties of ZMPC through research on this material. The results show that ZMPC has the same strength and toughness (25.3 ± 1.73 MPa to 20.18 ± 2.11 MPa), that meet the requirements of bone repair. Furthermore, the material can gradually degrade (12.27% ± 1.11% in 28 days) and promote osteogenic differentiation (relative protein expression level increased 2–3 times) of rat bone marrow mesenchymal stem cells (rBMSCs) in vitro. In addition, in vivo confirmation revealed increased bone regeneration in a rat calvarial defect model compared with MPC alone. Therefore, ZMPC has broad application prospects and is expected to be an important repair material in the field of orthopedic medicine.

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Section: Discussionmentioning

confidence: 99%