Tricalcium phosphate sheets with chitosan obtained via aqueous tape casting

Abstract

Tricalcium phosphate (TCP) is a biomaterial produced in several biomedical applications, in addition to having biocompatibility and osteoconductive capacity. Biodegradable polymers of natural or synthetic origin such as chitosan and polyvinyl alcohol (PVA) have been used for tissue engineering applications because they have the properties of the native organic phase of bone tissue. Thus, the objective of this study was to obtain ceramic tapes based on TCP, chitosan, and PVA through the tape casting method. The viscosity data for all suspensions were ideal for the chosen processing. The thermogravimetric curves showed similar profiles, and it was possible to observe that a greater total mass loss occurred with the increase in the chitosan content. XRD reflections related to the β-TCP phase of the orthorhombic structure were found, showing no phase transformation. SEM analysis showed degrees of roughness on the film surfaces with little influence from the increase in chitosan content.

Polymers as Encapsulating Agents and Delivery Vehicles of Enzymes

“…Electrostatic interactions with molecules containing negatively charged groups are developed as the amino groups of chitosan and its protonation, which generates NH 3+ , together with its linear chains, react. Furthermore, the presence of this functional group and a hydroxyl on chitosan chains allows for chemical modifications [ 34 ].…”