Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

Pereira, Emiliane Daher; Cerruti, Renata; Fernandes, Elton; Peña, Luis; Sáez, Vivian; Pinto, José Carlos; Ramón, José; Oliveira, Geiza E.; Júnior, Fernando Gomes de Souza

doi:10.1590/0104-1428.2323

Cited by 48 publications

(40 citation statements)

References 46 publications

(52 reference statements)

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“…A linear relationship between PEG content at 3.65 ppm and PLGA content at 4.82 and 5.23 ppm (insert in Figure ) was observed, R 2 = 0.935. The data confirm that polymer blending successfully produced NPs with different PEG contents …”

Section: Resultssupporting

confidence: 75%

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Influence of PEGylation on PLGA nanoparticle properties, hydrophobic drug release and interactions with human serum albumin

Samkange

D’Souza

Obikeze

et al. 2019

Journal of Pharmacy and Pharmacology

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Objective To evaluate the impact of PEG content on poly(lactic‐co‐glycolic acid) (PLGA) NP physicochemical properties, hydrophobic drug release (rifampicin as a model drug) and human serum protein binding. Methods Rifampicin loaded and unloaded nanoparticles with PEG content of 0–17% (w/w) were prepared by an emulsification–evaporation technique. Nanoparticles were characterized for size, zeta potential and morphology. PEGlyation was confirmed using proton nuclear magnetic resonance (1H NMR). Fluorescence spectroscopy and dynamic light scattering were used to determine nanoparticle‐protein binding, binding constants and stability of nanoparticles in human serum, respectively. Drug loading and release were determined by UV‐VIS spectroscopy and drug release data was mathematically modelled. Key findings A NP PEG content of 17% w/w significantly retarded release of rifampicin from PLGA NPs and altered kinetics of drug release. Stern–Volmer (Ksv) protein binding constants decreased upon PEG incorporation. A 2% w/w PEG was sufficient to significantly reduce protein binding extent to PLGA NPs and maintain particle size distributions. Conclusion The ability to fine tune drug release and formation of protein corona around nanoparticles is crucial to formulation scientists. This study suggests that PLGA NPs with low PEG content might be suitable for extended circulation and rapid drug release and that higher PEG content retards hydrophobic drug release.

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Section: Resultssupporting

confidence: 75%

“…The data confirm that polymer blending successfully produced NPs with different PEG contents. [39] Rifampicin loading in NPs as a function of PEG content…”

Section: Confirmation Of Np Peg Content Variationmentioning

confidence: 99%

Influence of PEGylation on PLGA nanoparticle properties, hydrophobic drug release and interactions with human serum albumin

Samkange

D’Souza

Obikeze

et al. 2019

Journal of Pharmacy and Pharmacology

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“…The Weight average molecular weight (Mw) for PBS was 7.5 kDa and the polydispersity (Mw/Mn) was 1.4. This engineered low molecular weight is useful to increase the actives species release from the delivery system, as proved elsewhere …”

Section: Resultsmentioning

confidence: 84%

“…According to this method, the higher the RMSE value for a comparison between a sample and its reference, the more significant the difference among their spectra . Thus, the RMSE test is an excellent indicator of small variations in the spectra, which cannot be visually identified.…”

Section: Resultsmentioning

confidence: 99%

Oil Biodegradation Systems Based on γ Irradiated Poly (Butylene Succinate)

Caetano

Bedor

Jesus

et al. 2018

Macromolecular Symposia

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The risks of environmental damage are inherent in oil activities, being a constant concern to our modern society. Among the remediation strategies, the biological one is safer and more inexpensive compared to physic‐chemicals approaches. Bioremediation can be enhanced using biodegradable polymers as coating materials of the nutrient release systems. However, some of these polymers can be improved using electromagnetic radiation, able to modify their properties, such as, molar mass, changing the materials physicochemical behavior. Thus, immobilizing urea in poly (butylene succinate) (PBS) matrix, producing a petroleum bioremediation tool was the primary goal in the paper herein. The composites were obtained by melting at 110 °C with subsequent application of gamma (γ) radiation at doses of 15, 25, 50, and 75 kGy. The obtained results allowed to infer that the increase of the γ radiation doses improved the immobilization, thus reducing the immediate urea release. Besides that, the preliminary biodegradation results showed that the highest rates of hydrocarbon reduction at the end of the analysis period were reached using the material irradiated at 25 kGy. These results are encouraging and proved that irradiated PBS‐urea systems could be used as oil spill disasters tool.

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“…This technique consists in heating the tumor cells, increasing their sensitivity to other treatments, as well as leading them to death. As the tumor cells are considerably less resistant to heat than the surrounding healthy cells, the hyperthermia treatment is cytoselective, producing fewer side effects in comparison to classic treatment of neoplasms …”

Section: Introductionmentioning

confidence: 99%

Hyperthermia System Based on Extrinsically Magnetic Poly (Butylene Succinate)

Moraes

Sáez

Hernández³

et al. 2018

Macromolecular Symposia

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In this work, an extrinsically magnetic composite based on modified magnetite and poly (butylene succinate) (PBS) is prepared. The magnetic composite is obtained by the emulsion–solvent evaporation method. Several analytical tests confirm the synthesis of the composites. Among them, Nuclear magnetic resonance (NMR) results in comparison with literature confirms the synthesis of PBS. X‐Ray Diffraction (XRD) shows the characteristic peaks of PBS, in its monoclinic structure. The crystallite size (Lc) of magnetic particles inside the composite, is equal to 13 nm. Thermogravimetric analysis (TGA) reveals the presence of 5.3 wt% magnetite in the composite and demonstrates that the inclusion of magnetite does not affect the thermal stability of the polymer. The analysis of Fourier transform infrared attenuated total reflection spectra (FTIR‐ATR) indicates the synthesis of desired products as well as the encapsulation of magnetite in PBS polymer matrix. The composite presents magnetic force, which allows its magnetic guidance to a target area. Besides, the magnetic induction heating test promotes heating within the therapeutic range from 40 to 45 °C, being able, according to literature, to promote the death of several types of cancer's cells. Therefore, the material here presented possesses potential to be deeply researched as a future cancer treatment tool.

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Influence of PLGA and PLGA-PEG on the dissolution profile of oxaliplatin

Cited by 48 publications

References 46 publications

Influence of PEGylation on PLGA nanoparticle properties, hydrophobic drug release and interactions with human serum albumin

Influence of PEGylation on PLGA nanoparticle properties, hydrophobic drug release and interactions with human serum albumin

Oil Biodegradation Systems Based on γ Irradiated Poly (Butylene Succinate)

Hyperthermia System Based on Extrinsically Magnetic Poly (Butylene Succinate)

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