Caracterização química e efeito cicatrizante de quitosana, com baixos valores de massa molar e grau de acetilação, em lesões cutâneas

Fráguas, Rodrigo Martins; Rocha, Denise Alvarenga; Queiroz, Estela de Rezende; Abreu, Celeste Maria Patto de; Sousa, Raimundo Vicente de; Júnior, Enio Nazaré de Oliveira

doi:10.1590/0104-1428.1778

Cited by 12 publications

(8 citation statements)

References 23 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chitosan hydration is related to the affinity of this molecule for water. Then, when chitosan is in its solid state, its macromolecules are easily hydrated (FRÁGUAS et al, 2015).…”

Section: Elementary Analysis Of Chitinmentioning

confidence: 99%

Recovery of chitin and chitosan from shrimp waste with microwave technique and versatile application

et al. 2019

View full text Add to dashboard Cite

In this study, chitin and chitosan were extracted from Litopenaeus vannamei waste using chemical and microwave methods. Shrimp waste was cleaned, dried and ground sieved to 16, 32 and 60 mesh, and the samples were depigmented, demineralized, and deproteinized. Then, the chitin was submitted to a deacetylation process by 45% NaOH solution under microwave irradiation at 600w, for intermittent 15 min or using 5 pulses of 5 minutes. The study showed that the effectiveness of the particle size of 32 mesh and 6 pulses of 5 min to deacetylation with 92% of degree and chitosan yield (52.2%). The polymer chitosan showed higher antimicrobial activity against to Staphylococcus aureus, Escherichia coli, Salmonella enterica and the yeast Candida sp., respectively. The results indicated the feasibility of the microwave radiation as an attractive method to recover chitin and chitosan from shrimp wastes.

show abstract

“…Chitosan hydration is related to the affinity of this molecule for water. Then, when chitosan is in its solid state, its macromolecules are easily hydrated (FRÁGUAS et al, 2015).…”

Section: Elementary Analysis Of Chitinmentioning

confidence: 99%

Recovery of chitin and chitosan from shrimp waste with microwave technique and versatile application

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Ambos os achados ao 3º e 7º dias correspondem aos encontrados por outros estudos. [10][11][12][13][14][15] Ao 14º dia, ambas as feridas das regiões DD e DE apresentaram coaptação de forma semelhante, mas destacam-se as características cicatriciais observadas nas amostras DD, nas quais a cicatrizes foram quase imperceptíveis.…”

Section: Discussionunclassified

Análise histológica comparativa do reparo tecidual após síntese com fio de nylon e adesivo de Etil-2-cianoacrilato em feridas cutâneas de ratos

Ramos

Negreiros

Batista

et al. 2020

BJD

View full text Add to dashboard Cite

Diversas pesquisas buscam novos agentes para síntese de lesões cutâneas, pois embora existam no mercado inúmeras opções de curativos e tratamentos para lesões, grande parte dos produtos apresentam custos elevados ao paciente. Partindo desse pressuposto, este trabalho objetivou realizar um estudo de não superioridade do etil-2-cianoacrilato (SuperBonder®) frente ao material de síntese Nylon 5.0 em feridas cutâneas, analisando os aspectos macroscópicos e microscópicos teciduais. Para a pesquisa foram utilizados doze ratos albinos Wistar (Rattus norvergicus) machos divididos em

show abstract

“…Fráguas, et al [204] performed CS chemical characterization to study this material's healing effect on skin lesions of rats. They observed that in the evolution of the skin lesion healing, both in the control group and in the chitosan-treated group, superficial crust formation occurred until week 1 (7th day), from which there was a thickening of this crust.…”

Section: Chitosan In Wound Healingmentioning

confidence: 99%

A Review on Chitosan’s Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment

et al. 2020

View full text Add to dashboard Cite

Chitosan, derived from chitin, is a biopolymer consisting of arbitrarily distributed β-(1-4)-linked D-glucosamine and N-acetyl-D-glucosamine that exhibits outstanding properties— biocompatibility, biodegradability, non-toxicity, antibacterial activity, the capacity to form films, and chelating of metal ions. Most of these peculiar properties are attributed to the presence of free protonable amino groups along the chitosan backbone, which also gives it solubility in acidic conditions. Moreover, this biopolymer can also be physically modified, thereby presenting a variety of forms to be developed. Consequently, this polysaccharide is used in various fields, such as tissue engineering, drug delivery systems, and cancer treatment. In this sense, this review aims to gather the state-of-the-art concerning this polysaccharide when used as a biomaterial, providing information about its characteristics, chemical modifications, and applications. We present the most relevant and new information about this polysaccharide-based biomaterial’s applications in distinct fields and also the ability of chitosan and its various derivatives to selectively permeate through the cancer cell membranes and exhibit anticancer activity, and the possibility of adding several therapeutic metal ions as a strategy to improve the therapeutic potential of this polymer.

show abstract

Caracterização química e efeito cicatrizante de quitosana, com baixos valores de massa molar e grau de acetilação, em lesões cutâneas

Cited by 12 publications

References 23 publications

Recovery of chitin and chitosan from shrimp waste with microwave technique and versatile application

Recovery of chitin and chitosan from shrimp waste with microwave technique and versatile application

Análise histológica comparativa do reparo tecidual após síntese com fio de nylon e adesivo de Etil-2-cianoacrilato em feridas cutâneas de ratos

A Review on Chitosan’s Uses as Biomaterial: Tissue Engineering, Drug Delivery Systems and Cancer Treatment

Contact Info

Product

Resources

About