Human papillomavirus detection in cervical scrapes from women attended in the Family Health Program

Augusto, Everton Faccini; Santos, Larissa Silva; Oliveira, Ledy H. S.

doi:10.1590/0104-1169.3189.2398

Cited by 6 publications

(6 citation statements)

References 16 publications

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“…Young age is a classical independent factor associated to HPV infection and it is well reported in the scientific literature. 8 , 17 , 18 It is related to the more intense sexual activity in this age (that favors the infection) as well as to an anatomical characteristic of the young women (cervical ectopy) that exposes the columnar epithelium in the ectocervix, making it more vulnerable to pathogen infections. 19 , 20 …”

Section: Discussionmentioning

confidence: 99%

“…These studies demonstrated that HPV infection was associated with multiple sexual partners 6 ; young age, more lifetime sex partners and abnormal vaginal flora 7 and non-stable sexual partners. 8 HPV persistence also presented frequencies as different as 19.2% in Porto Alegre (Rio Grande do Sul state) and 59.6% in Ouro Preto (Minas Gerais state) in two studies performed in primary public health care clinics from Brazil. 9 , 10 …”

Section: Introductionmentioning

confidence: 94%

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Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil

Coser

Boeira

Wolf

et al. 2016

The Brazilian Journal of Infectious Diseases

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Human papillomavirus (HPV) infection is common in sexually active women and viral persistence may cause intraepithelial lesions and eventually progress to cervical cancer (CC). The present study aimed to investigate epidemiological factors related to HPV infection and to evaluate viral persistence and CC precursor lesions frequencies in women from a city in the countryside of South Brazil. Three hundred women were recruited from a primary public health care clinic. The patients were interviewed and underwent sampling with cervical brushes for HPV-DNA detection/typing by a PCR-based assay and cytological analysis by Pap smear test. HPV was detected in 47 (15.7%) women. HPV infection was significantly associated with young age (<30 years) and low socio-economic status. Seventeen (5.7%) women presented cytological abnormalities, three of them with precursor CC intraepithelial lesions. A subgroup of 79 women had been previously analyzed and thirteen (16.4%) were persistently infected, two with precursor CC intraepithelial lesions and high-risk HPV types infection (both of them without cervical abnormalities in the first exam). In conclusion, HPV infection was associated with young age (<30 years) and low family income; viral persistence was low (16.4%) but related to CC precursor lesions; and HPV-DNA high risk types detection would help to screen CC in the population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil

Coser

Boeira

Wolf

et al. 2016

The Brazilian Journal of Infectious Diseases

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“…Having multiple partners exposes women more to HPV infection when compared to women who had a single partner within more than one year, representing a risk factor for HPV 12 .…”

Section: Discussionmentioning

confidence: 99%

Knowledge, attitude and practice of the smear test and its relation with female age

Silveira

Vasconcelos

Nicolau

et al. 2016

Rev. Latino-Am. Enfermagem

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Objective: to verify the association among the knowledge attitude and practice of women in relation to the smear test and the age range. Method: a cross-sectional research was undertaken, associated with the knowledge, attitude and practice survey at a Primary Health Care service. The sample consisted of 775 women, distributed in three age ranges: adolescent, young and elderly. Results: although high rates of inappropriate knowledge were found in all age ranges, it was significantly higher among the adolescents (p=0.000). A similar trend was found in the attitude component, with percentages of inappropriateness in adolescence that drop as age advances (p=0.000). Nevertheless, no statistical difference among the groups was found in terms of practice (p=0.852). Conclusion: the study demonstrated a relation between the age range and knowledge, attitude and practice of the smear test.

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“…As there is no biological plausibility for alcoholism to be considered a protective factor for acquiring HPV infection, we believe that there may have been an information bias at the time of application of the questionnaire or perhaps alcoholism expresses another variable that was not considered in the study. Alcohol abuse was not shown to be associated with cervical infection due to HPV among HIV-positive ( Melgaço et al 2011 ) and HIV-negative women in southeastern Brazil ( Augusto et al 2014 ).…”

Section: Discussionmentioning

confidence: 99%

Prevalence of human papillomavirus infection, distribution of viral types and risk factors in cervical samples from human immunodeficiency virus-positive women attending three human immunodeficiency virus-acquired immune deficiency syndrome reference centres in northeastern Brazil

Martins

Lucena‐Silva

Garcia

et al. 2014

Mem. Inst. Oswaldo Cruz

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Human immunodeficiency virus (HIV)-positive patients have a greater prevalence of coinfection with human papillomavirus (HPV) is of high oncogenic risk. Indeed, the presence of the virus favours intraepithelial squamous cell lesion progression and may induce cancer. The aim of this study was to evaluate the prevalence of HPV infection, distribution of HPV types and risk factors among HIV-positive patients. Cervical samples from 450 HIV-positive patients were analysed with regard to oncotic cytology, colposcopy and HPV presence and type by means of polymerase chain reaction and sequencing. The results were analysed by comparing demographic data and data relating to HPV and HIV infection. The prevalence of HPV was 47.5%. Among the HPV-positive samples, 59% included viral types of high oncogenic risk. Multivariate analysis showed an association between HPV infection and the presence of cytological alterations (p = 0.003), age greater than or equal to 35 years (p = 0.002), number of partners greater than three (p = 0.002), CD4+ lymphocyte count < 200/mm3 (p = 0.041) and alcohol abuse (p = 0.004). Although high-risk HPV was present in the majority of the lesions studied, the low frequency of HPV 16 (3.3%), low occurrence of cervical lesions and preserved immunological state in most of the HIV-positive patients were factors that may explain the low occurrence of precancerous cervical lesions in this population.

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Human papillomavirus detection in cervical scrapes from women attended in the Family Health Program

Cited by 6 publications

References 16 publications

Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil

Cervical human papillomavirus infection and persistence: a clinic-based study in the countryside from South Brazil

Knowledge, attitude and practice of the smear test and its relation with female age

Prevalence of human papillomavirus infection, distribution of viral types and risk factors in cervical samples from human immunodeficiency virus-positive women attending three human immunodeficiency virus-acquired immune deficiency syndrome reference centres in northeastern Brazil

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