Crop models can provide rapid and cost effective means to deal with rice crop management. The objectives of this study included, exploring the ability of CSM-CERES-Rice in scheduling irrigation and to simulate the effect of drought stress on upland rice yield. Irrigation treatments 100, 70 and 50 % of field capacity (FC) were applied from 80 days after planting (DAP) at flowering stage until maturity and CSM-CERES-Rice was used to predict irrigation amount for each water regime for treatment duration. Results showed that, at 70 and 50 % FC, performance of an upland rice genotype, Dawk Payawm was decreased significantly as compared to 100 % FC. Normalized root mean square error (RMSEn) values less than 10 % for each treatment indicated a strong agreement between simulated and observed grain yield (GY) and biomass. d-index approaching to unity and RMSEn less than 10 % indicated a good agreement between simulated and observed soil moisture contents (SMC) for all irrigation treatments. Overall, it was concluded that drought stress had negative correlation with GY and CSM-CERES-Rice was able to predict irrigation amount for all treatments assuring that, model has potential for its use as a tool to schedule irrigation for experiments under water limited conditions.