Conjoint use of inorganic and organic amendments can be a pragmatic solution for improving soil physico-chemical and biological properties and sustaining crop productivity. Keeping in this view a pot experiment was conducted during rabi season of 2015-16 in net house of AICRP on Management of Salt Affected soils and use of Saline Water in Agriculture, College of Agriculture, Indore to study the effect of recommended doses of fertilizer and biogas slurry on uptake and content of NPK in wheat grown under sodic Vertisols. The treatment comprised of T0-Control, T1-100% RDF, T2- 100% RDF + 750 kg BGS ha-1, T3-75% RDF + 750 kg BGS ha-1, T4- 50% RDF + 750 kg BGS ha-1, T5- 100% RDF + 1000 kg BGS ha-1, T6-75% RDF + 1000 kg BGS ha-1, T7-50% RDF + 1000 kg BGS ha-1, T8-100% RDF + 1250 kg BGS ha-1, T9-75% RDF+ 1250 kg BGS ha-1, T10-50% RDF+ 1250 kg BGS ha-1 were laid in completely randomized design with 3 replications. Results showed that the treatment T9 (75% RDF+1250 kg BGS ha-1) gave maximum dry matter production (0.205, 0.434 and 0.821 g plant-1, respectively), N content (2.39, 1.58 and 1.36% respectively), P content (0.41, 0.30 and 0.24%, respectively) and K content (1.24, 0.68 and 1.68%, respectively) in wheat leaf at 30, 60 and 90 DAS. Maximum uptake of N (1.20 and 0.72 g pot-1, respectively), P (0.132 and 0.119 g pot-1, respectively) and K (0.237 and 1.08 g pot-1, respectively) by grain and straw of wheat respectively, were found with the application of T9 (75% RDF+1250 kg BGS ha-1). Thus, it may be concluded that integrated application of T9 (75% RDF+1250 kg BGS ha-1) not only increases dry matter production but also content and uptake by wheat.