Hypertrophic osteopathy and bone metastases in a dog with prostatic carcinoma

Abstract

Prostatic carcinomas in are aggressive neoplasms and bone metastases may occur; however, hypertrophic osteopathy associated with that condition is poorly documented. A ten-year-old, neutered male, mixed breed dog had a history of lameness and volume increase in the left pelvic limb. On radiographic examination, a lytic bone mass was observed in the left metatarsus, as well as a diffuse proliferative periosteal reaction in several bones of the appendicular skeleton, in addition to radiopaque nodular structures in all lung lobes. A presumptive diagnosis of primary bone neoplasia with pulmonary metastases and hypertrophic osteopathy was established and chemotherapy treatment was started. However, there was no satisfactory clinical response, and euthanasia was ellected. At necropsy, there was moderate enlargement of the prostate gland. The gland was firm and whitish, with a multilobulated aspect. Several similar masses were observed in the right kidney, lungs, mediastinal lymph nodes, and multiple bones of the appendicular skeleton. These bones also presented evident diffuse periosteal reaction. Histological examination revealed a metastatic prostatic carcinoma with bone involvement and hypertrophic osteopathy. This report is an unusual case of metastatic prostatic carcinoma in association with hypertrophic osteopathy and concomitant bone metastases.

Adenocarcinoma metastático de glândula hepatoide em cão (Canis lupus)

“…Horta (2011) relata o caso de uma cadela fêmea, sem raça definida, que apresentou metástase em vértebras lombares após seis meses de excisão cirúrgica de um adenocarcinoma de hepatoide. Vielmo (2020) observou múltiplos focos metastáticos em rim, fígado e esqueleto apendicular, além de destruição e substituição óssea por tecido neoplásico em toda extensão de membro pélvico em um cão, macho, sem raça definida, de 10 anos, diagnosticado com carcinoma prostático.…”