Leiomyosarcoma in a cockatiel

Bonel, Josiane; Alberti, Taina dos Santos; Stumm, Geovana Kramer Fiala; Gamba, Conrado de Oliveira; Bandarra, Paulo Mota; Cassali, Geovanni Dantas

doi:10.1590/0103-8478cr20180858

Cited by 3 publications

(2 citation statements)

References 7 publications

(2 reference statements)

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“…However, they do not express immunolabeling for C-KIT. (4,19,40). Neoplasms of epithelial origin, such as proventricular adenocarcinoma, are considered possible differentials in this case due to mucosal thickening and proventricular dilatation in addition to strong cytoplasmic immunolabeling of neoplastic cells for pancytokeratin (2,26,37).…”

Section: Discussionmentioning

confidence: 90%

Proventricular and ventricular gastrointestinal stromal tumor (GIST) in a scarlet macaw (Ara chloropterus)

Paranhos,

Silva,

Duarte

et al. 2024

BJVP

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GISTs can be benign or malignant, and they have been reported in a wide variety of species, including humans, non-human primates, dogs, and cats; however, reports of this tumor in birds are rare. These neoplasms are seen in the gastrointestinal tract and are derived from the Cajal Cells responsible for regulating gastrointestinal motility. We report a case of a gastrointestinal stromal tumor in a scarlet macaw (Ara chloropterus) that was referred to necropsy at the Veterinary Hospital of the Federal University of Paraíba (UFPB), Northeastern Brazil. Macroscopically, the proventriculus and ventriculus were dilated, and the walls of both organs were thickened by a firm, ulcerated mass covered by fibrin strands. In the histopathology, the proventriculus presented an expansive, non-encapsulated neoplasm formed by homogeneous spindle cells, with eosinophilic cytoplasm, indistinct borders, mild to moderate pleomorphism, and rare mitotic figures, being suggestive of a leiomyoma. In immunohistochemistry, a positive multifocal immunolabeling for the C-KIT proto-oncogene was observed in the cytoplasm of neoplastic spindle cells, thus compatible with a gastrointestinal stromal tumor (GIST). The occurrence of GISTs in avian species might have been overlooked, and the authors recommend that previously reported gastrointestinal leiomyomas or leiomyosarcomas be tested for this immunomarker to rule out the possibility of GISTs.

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Section: Discussionmentioning

confidence: 90%

Proventricular and ventricular gastrointestinal stromal tumor (GIST) in a scarlet macaw (Ara chloropterus)

Paranhos,

Silva,

Duarte

et al. 2024

BJVP

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“…Pet birds with neoplastic diseases are currently more frequently submitted veterinarians before death possibly because the medical care improvements for oncologic patients (44). The following types of neoplasms have been reported in pets birds: epithelialfolliculoma (3,44), basal cell carcinoma (3,44,58), squamous cell carcinoma (12,31), papilloma (29,32,38), cholangiocarcinoma (11,15,33), pulmonary carcinoma (20,32), air sac carcinoma (30,40,42) and renal carcinoma (32,54); mesenchymalfibroma (32,41) and fibrosarcoma (7,27,45), hemangioma and hemangiosarcoma (7,44,55), lipoma and liposarcoma (7, 2 27), chondrosarcoma (32), hemangiolipoma (50), osteoma and osteosarcoma (6,17,51), leiomyosarcoma (2,32), and rhabdomyosarcoma (1); hematopoietic and hemolymphatic lymphoma (7,8,32), myelolipoma (25,35) and thymoma (23,44)...…”

Section: Introductionmentioning

confidence: 99%

A retrospective study of neoplasms in ornamental and pet birds diagnosed at the Hospital de Aves of the Universidad Nacional Autónoma de México (2007-2014)

Sánchez-Godoy¹,

Ledesma-Ramírez²,

Salinas³

2020

BJVP

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A retrospective study including a total of 44 ornamental and pet birds with neoplasms diagnosed at the Hospital de Aves, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México from January 2007 to April 2014 was conducted. Most of affected birds were Psittaciformes (n=26, 59%) including budgerigars (Melopsittacus undulatus) (n=12/26, 46.15%) and amazon parrots (Amazona spp.) (n=7/26, 26.92%), and followed by Passeriformes and Anseriformes (n=7/44, 15.90%, each) and Galliformes (n=4/44, 9.09%). The youngest studied bird was a 6.5-week-old lovebird (Agapornis sp.) with a papilloma, and the oldest bird was a 37-year-old yellow-naped parrot (Amazona auropalliata) with a hemangiosarcoma. Most of the affected birds were adults (n=23, 52.27%). The gender was determined for 17 birds (38.63%), of which eight (47.05%) were females and nine (52.94%) males. There were 45 reported neoplasms, as one salmon-crested cockatoo (Cacatua moluccensis) had two neoplasms. The two most frequent neoplasms were fibrosarcomas (n=9/45, 20%) and hemangiosarcomas (n=5/45, 11.11%). The largest number of neoplasms was found in the integumentary system (n=18/45, 40%), followed by the reproductive system (n=10/45, 22.22%). Of the 16 types of neoplasms, seven (43.75%) were malignant, six (37.5%) were benign, and three (18.75%) were potentially malignant. This study showed similarities with retrospective previously reported studies and contributes to the knowledge of the neoplastic diseases that occur in ornamental and pet birds in Mexico.

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Histological and immunohistochemical evaluation of epithelial and mesenchymal tumors of psittacines

Bamaç

Arun²

2020

Medycyna Weterynaryjna

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This study describes histological and immunohistochemical evaluation of 50 epithelial and mesenchymal tumors of psittacines that were found in the archives of the pathology departments of veterinary faculties at Utrecht University and Istanbul University Cerrahpasa. In each case, cellular morphological features, tumoral pattern and mitotic activity were evaluated histologically, and immunohistochemistry was performed by the streptavidin-biotin immunoperoxidase method using a panel of commercially available antibodies raised against pan-cytokeratin, vimentin, muscle-specific actin, desmin, smooth muscle actin and Factor VIII/von Willebrand Factor. The histological evaluation revealed that 30 epithelial tumors were squamous cell carcinoma (n: 20), renal adenocarcinoma (n: 3), basal cell carcinoma (n: 2), abdominal carcinoma (n: 2), uropygial gland carcinoma (n: 1), cloacal carcinoma (n: 1) and cholangiocarcinoma (n: 1). Out of the 50 tumors, 13 had a mesenchymal origin and were diagnosed as fibrosarcoma (n: 4), hemangioma (n: 3), hemangiosarcoma (n: 4) and leiomyosarcoma (n: 2). Histological diagnosis could not be made for 7 tumors, and they were evaluated as undifferentiated malignant tumors (UDMT). Two tumors diagnosed as fibrosarcoma and three tumors diagnosed as UDMT showed strong SMA staining and were re-diagnosed as leiomyosarcoma. In view of the IHC findings, two other UDMTs were re-diagnosed as fibrosarcoma and anaplastic carcinoma. Although only a limited number of antibodies were used in the control panel, they were useful in establishing a definite diagnosis in some cases

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Leiomyosarcoma in a cockatiel

Cited by 3 publications

References 7 publications

Proventricular and ventricular gastrointestinal stromal tumor (GIST) in a scarlet macaw (Ara chloropterus)

Proventricular and ventricular gastrointestinal stromal tumor (GIST) in a scarlet macaw (Ara chloropterus)

A retrospective study of neoplasms in ornamental and pet birds diagnosed at the Hospital de Aves of the Universidad Nacional Autónoma de México (2007-2014)

Histological and immunohistochemical evaluation of epithelial and mesenchymal tumors of psittacines

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