Mannheimia haemolytica pleuropneumonia in goats associated with shipping stress

Abstract

This study described the epidemiological, clinical, pathological and bacteriological aspects of Mannheimia haemolytica pleuropneumonia in goats associated with shipping stress. Forty goats transported from the Northeast to the Southern region of Brazil died during shipment, or 2-3 days after unloading. Clinical signs included dyspnea, mucopurulent nasal discharge, and coughing. All goats were necropsied, and multiple tissues were collected for histopathological analysis and involved agent identifications. All lungs showed pulmonary consolidation, predominantly affecting the cranioventral lobes, in addition to the marked fibrinous pleuritis, pleural thickening, and pleural adhesions, that affected 90% of the goats. Histologically, there was fibrino-suppurative pleuropneumonia characterized by a diffuse neutrophilic infiltrate admixed with fibrin. Non-hemolytic [85% (34/40)] and hemolytic [15% (6/40)] species were obtained in bacteriological culture. Fir Mannheimia spp. was reported in 26 isolates and subsequently confirmed as M. haemolytica (99% identity), after amplification and partial sequencing of the 16S rDNA gene. Stress may trigger the development of bacterial pleuropneumonia in goats, and non-hemolytic strains of M. haemolytica may cause this condition in goats with severe immunosuppression.

Biological and molecular characterization of a sheep pathogen isolate of Mannheimia haemolytica and leukotoxin production kinetics

“…It is caused by Mannheimia haemolytica (Mha), a Gram-negative, optional anaerobic, nonmotile, and opportunistic pathogen. This organism changes from a benign commensal to a deadly pathogen by colonizing the lower respiratory tract during stress (viral infection, physical condition, transport, immuno-depression, and environment), causing variable pneumonia types [2]. Clinical signs vary in intensity from frustrating to severe, rapidly fatal infection, characterized by anorexia, tachycardia, weight loss, rhinitis, cough, and polypnea, followed by dyspnea.…”

Detection of Contagious Caprine Pleuropneumonia and Concurrent Diseases in Outbreaks Presenting with Respiratory Signs in Small Ruminants in Tanzania

“…A total of 148 goats were examined, majority of them, 79.1% (117) had concurrent infections and these were detected from 70.9% (105) clinically examined animals and 29.1% (43) autopsied animals. Concurrent diseases detected in high proportions were M. capricolum pneumonia and PPR, 11.1% (13), M. capricolum pneumonia and pneumonic pasteurellosis, 9.4% (10) and pneumonic pasteurellosis and PPR, 9.4% (10). Detection of all diseases was significantly low in clinically examined animals (p<0.05), except in the detection of pneumonic pasteurellosis and PPR where the detection was high in clinically examined animals but with no statistical 3).…”

“…"cluster" [7,8]. Contagious caprine pleuropneumonia lesions are localized within the respiratory system causing acute to chronic pneumonic conditions, the main clinical signs include, nasal discharges, coughing, respiratory distress, emaciation, posture with extended elbow whereas, pathological lesions are, serofibrinous pleurisy, serosanguinous hydrothorax, unilateral lung inflammation and lung hepatization [1,9,10].…”

A Review on the Potential Effects of Combination Treatments of Anti-microbial and Anti-inflammatory Drugs Towards Male Reproductive Physiology in Pneumonic Bucks

“…Additionally, acute infection of M. haemolytica was more severe in goats than cattle of which the infection may expected to cause mortality in animal within 24 hours or may cleared off after a few days, should the animal survived (Hanzlicek et al 2010). Pneumonia due to M. haemolytica is characterized by acute cranioventral fibrinous to fibrinopurulent pleuropneumonia where extensive infiltration of neutrophils and exudation of fibrin into the pleura, alveoli, bronchi and bronchioles were observed (Taunde et al 2019;Rawat et al 2019;Alarawi and Saeed 2021).…”