Myolipoma associated with hyperadrenocorticism and diabetes mellitus in a female poodle

Abstract

This report provides an unpublished account of an intra-abdominal myolipoma in a 11-year-old female Poodle with hyperadrenocorticism and diabetes mellitus. The patient was well controlled for both endocrine diseases; however, was suffering for severe abdominal discomfort. Ultrasound scan revealed a huge abdominal mass. At necropsy a pinkish mass (35cm x 28cm x 12cm) of elastic consistency attached to the broad ligament of the left uterine horn was reported. Histologically, this mass was constituted of a mixed population of well-differentiated adipocytes and of spindle-shaped mesenchymal cells. Both tumor cells were positive for vimentin at immunohistochemistry, while the spindle-shaped cells were positive for desmin and actin, compatible with smooth muscle cells. Immunohistochemistry was crucial for myolipoma characterization.

Progesterone-Related Diabetes Mellitus in the Bitch: Current Knowledge, the Role of Pyometra, and Relevance in Practice

“…In this scenario, the role played by the inflammatory environment in inducing additional insulin resistance seemed to explain worsened insulin sensitivity due to pyometra compared with the isolated diestrus influences [ 16 ]. Chronic inflammation due to obesity [ 116 , 117 , 118 , 119 ] or periodontitis [ 120 , 121 ], leading to insulin resistance, represents other examples of the negative effect of inflammation on insulin sensibility in dogs. These findings allowed the assumption that conditions such as diestrus and pyometra can exert insulin resistance at the IR and post-IR levels, and mechanisms such as IR upregulation represent a potential peripheral compensatory modulation [ 52 , 79 , 81 ].…”