Antimicrobial wound dressing films containing essential oils and oleoresins of pepper encapsulated in sodium alginate films

Rosa, Jessica Miranda; Bonato, Letícia Bicudo; Mancuso, Carolina Bragine; Martinelli, Laira; Okura, Mônica Hitomi; Malpass, Geoffroy Roger Pointer; Granato, Ana Cláudia

doi:10.1590/0103-8478cr20170740

Cited by 15 publications

(8 citation statements)

References 21 publications

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“…For example, EOs of thyme, peppermint, lavender, cinnamon, tea tree, rosemary, eucalyptus, lemongrass, etc., have been found to have antimicrobial properties [ 109 ]. In addition to antibiotics and antiseptics, EOs have been integrated in wound dressings to function as antibacterial agents [ 110 , 111 ]. However, despite their helpfulness in treating wound infections, one may require a repetitive application and/or high concentrations that may result in adverse effects on the patient.…”

Section: Antibacterial Agents In Wound Dressingsmentioning

confidence: 99%

Treatment Strategies for Infected Wounds

2018

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The treatment of skin wounds is a key research domain owing to the important functional and aesthetic role of this tissue. When the skin is impaired, bacteria can soon infiltrate into underlying tissues which can lead to life-threatening infections. Consequently, effective treatments are necessary to deal with such pathological conditions. Recently, wound dressings loaded with antimicrobial agents have emerged as viable options to reduce wound bacterial colonization and infection, in order to improve the healing process. In this paper, we present an overview of the most prominent antibiotic-embedded wound dressings, as well as the limitations of their use. A promising, but still an underrated group of potential antibacterial agents that can be integrated into wound dressings are natural products, especially essential oils. Some of the most commonly used essential oils against multidrug-resistant microorganisms, such as tea tree, St. John’s Wort, lavender and oregano, together with their incorporation into wound dressings are presented. In addition, another natural product that exhibits encouraging antibacterial activity is honey. We highlight recent results of several studies carried out by researchers from different regions of the world on wound dressings impregnated with honey, with a special emphasis on Manuka honey. Finally, we highlight recent advances in using nanoparticles as platforms to increase the effect of pharmaceutical formulations aimed at wound healing. Silver, gold, and zinc nanoparticles alone or functionalized with diverse antimicrobial compounds have been integrated into wound dressings and demonstrated therapeutic effects on wounds.

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Section: Antibacterial Agents In Wound Dressingsmentioning

confidence: 99%

Treatment Strategies for Infected Wounds

2018

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“…Researchers have been searching for microencapsulation systems of oleoresin for different applications. Oleoresins successfully extracted from different natural sources were encapsulated in various systems such as: chitosan and alginate for fresh milk preservatives [25]; chitosan-alginate complex, gum arabic and modified starch, gum arabic and soy protein isolate, binary and ternary blends of gum arabic, maltodextrin and a modified starch as wall materials using spray drying [26][27][28][29], or as oleoresins of pepper encapsulated in sodium alginate films with essential oils as treatment for infected wounds [30].…”

Section: Coatings 2019 9 X For Peer Review 8 Of 10mentioning

confidence: 99%

Design and Development of Oleoresins Rich in Carotenoids Coated Microbeads

et al. 2019

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The aim of this study was to encapsulate the oleoresins rich in carotenoids extracted from sea buckthorn (Hippophae rhamnoides) fruits into a blend of sodium-alginate and κ-carrageenan microbeads (2% w/v) coated by a sodium-alginate (2% w/v) layer prepared using an ionotropic gelation technique with calcium chloride (2% w/v) by dropping method. The fresh obtained coated microbeads had a “fried eggs” like appearance with a size distribution ranging from 4 to 6 mm. The coated microbeads were analyzed for their SEM and fluorescence. The encapsulation efficiency was 92%. Their stability was investigated by evaluation of the physical integrity performance in aqueous media with different pH to mimic the gastrointestinal tract for 24 h at 37 °C under laboratory conditions. The results demonstrated the limitation of the coated microbeads swelling ability under pH 7. The coated microbeads could be a good tool to guarantee oleoresins rich in carotenoids stability and colon delivery. The present study shows an attractive encapsulation system of oleoresins, in order to obtain stable products for further applications.

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“…Based on presented scientific reports, it can be concluded that numerous of the biomaterial key features may be improved by the incorporation of curcumin component. Importantly, addition of curcumin not only may provide antibacterial properties of the dressing but also it can improve cell proliferation and growth or could even be used for anticancer treatment [55,59,63,64]. Moreover, curcumin-loaded biomaterials may reveal improved mechanical and physicochemical properties.…”

Section: Curcumin-loaded Biomaterialsmentioning

confidence: 99%

Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties

Vivcharenko

Przekora

2021

Applied Sciences

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The great variety of wounds and the lack of an effective universal treatment method has resulted in high demand for modern treatment strategies. Traditional approaches are often ineffective on a variety of chronic wounds, such as venous ulcers or the diabetic foot ulcer. There is strong evidence that naturally derived bioactive compounds have pro-healing properties, raising a great interest in their potential use for wound healing. Plant-derived compounds, such as curcumin and essential oils, are widely used to modify materials applied as wound dressings. Moreover, dressing materials are more often enriched with vitamins (e.g., L-ascorbic acid, tocopherol) and drugs (e.g., antibiotics, inhibitors of proteases) to improve the skin healing rate. Biomaterials loaded with the above-mentioned molecules show better biocompatibility and are basically characterized by better biological properties, ensuring faster tissue repair process. The main emphasis of the presented review is put on the novel findings concerning modern pro-healing wound dressings that have contributed to the development of regenerative medicine. The article briefly describes the synthesis and modifications of biomaterials with bioactive compounds (including curcumin, essential oils, vitamins) to improve their pro-healing properties. The paper also summarizes biological effects of the novel wound dressings on the enhancement of skin regeneration. The current review was prepared based on the scientific contributions in the PubMed database (supported with Google Scholar searching) over the past 5 years using relevant keywords. Scientific reports on the modification of biomaterials using curcumin, vitamins, and essential oils were mainly considered.

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Antimicrobial wound dressing films containing essential oils and oleoresins of pepper encapsulated in sodium alginate films

Cited by 15 publications

References 21 publications

Treatment Strategies for Infected Wounds

Treatment Strategies for Infected Wounds

Design and Development of Oleoresins Rich in Carotenoids Coated Microbeads

Modifications of Wound Dressings with Bioactive Agents to Achieve Improved Pro-Healing Properties

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