Experimental infection of horses with Vaccinia virus

Barbosa, Cláudio Henrique Gonçalves; Sant’Ana, Fabiano José Ferreira de; Cargnelutti, Juliana Felipetto; Flores, Eduardo Furtado; Neto, Antônio Raphael Teixeira; Santana, Rosália Bezerra de; Reis, Janildo Ludolf

doi:10.1590/0103-8478cr20150289

Cited by 1 publication

(1 citation statement)

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“…It has been suggested that VACV is more successful in replicating and being shed by bovines as compared to equids; the experimental infection in equids with Brazilian samples of VACV indicated a low level of replication at the inoculation site with mild cutaneous lesions when compared with the course of infection of other hosts. The authors hypothesized equids have a low potential for viral maintenance and transmission to other species, albeit being susceptible to VACV infection ( Barbosa et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Serological Evidence of Orthopoxvirus Circulation Among Equids, Southeast Brazil

et al. 2018

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Since 1999 Vaccinia virus (VACV) outbreaks involving bovines and humans have been reported in Brazil; this zoonosis is known as Bovine Vaccinia (BV) and is mainly an occupational disease of milkers. It was only in 2008 (and then again in 2011 and 2014) however, that VACV was found causing natural infections in Brazilian equids. These reports involved only equids, no infected humans or bovines were identified, and the sources of infections remain unknown up to date. The peculiarities of Equine Vaccinia outbreaks (e.g., absence of human infection), the frequently shared environments, and fomites by equids and bovines in Brazilian farms and the remaining gaps in BV epidemiology incited a question over OPV serological status of equids in Brazil. For this report, sera from 621 equids - representing different species, ages, sexes and locations of origin within Minas Gerais State, southeast Brazil – were examined for the presence of anti-Orthopoxvirus (OPV) antibodies. Only 74 of these were sampled during an Equine Vaccinia outbreak, meaning some of these specific animals presented typical lesions of OPV infections. The majority of sera, however, were sampled from animals without typical signs of OPV infection and during the absence of reported Bovine or Equine Vaccinia outbreaks. Results suggest the circulation of VACV among equids of southeast Brazil even prior to the time of the first VACV outbreak in 2008. There is a correlation of OPVs outbreaks among bovines and equids although many gaps remain to our understanding of its nature. The data obtained may even be carefully associated to recent discussion over OPVs history. Moreover, data is available to improve the knowledge and instigate new researches regarding OPVs circulation in Brazil and worldwide.

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Section: Discussionmentioning

confidence: 99%