Coadministration of ibuprofen/caffeine on bleaching-induced tooth sensitivity: A randomized clinical trial

Abstract

This clinical trial evaluated the effect of the coadministration of ibuprofen/caffeine on bleaching-induced tooth sensitivity (TS). A triple-blind, parallel-design, randomized clinical trial was conducted on 84 patients who received ibuprofen/caffeine or placebo capsules. The drugs were administered for 48 hours, starting 1 hour before the in-office bleaching. Two bleaching sessions were performed with 35% hydrogen peroxide gel with 1-week interval. TS was recorded up to 48 hours after dental bleaching with a 0-10 visual analogic scale (VAS) and a 5-point numeric rating scale (NRS). The color was evaluated with VITA Classical and VITA Bleachedguide scales (ΔSGU) and VITA Easyshade spectrophotometer (ΔE*ab and ΔE00). The absolute risk of TS in both groups was evaluated using Fischer's exact test. Comparisons of the TS intensity (NRS and VAS data) were performed by using the Mann-Whitney test and a two-way repeated measures ANOVA, respectively. The color alteration between the groups was compared with the Student's t test. The significance level was 5%. There was no statistically significant difference between the groups for the absolute risk of TS (p = 1.00) or for the intensity of TS (p > 0.05). A bleaching of approximately 7 shade guide units was observed on the Vita Classical and Vita Bleachedguide scales, with no statistical difference between the groups. It was concluded that coadministration of ibuprofen and caffeine did not reduce the absolute risk or intensity of TS and did not interfere with the efficacy of dental bleaching.

Effect of antioxidant on tooth sensitivity after bleaching

“…The degree of teeth sensitivity of each participant was evaluated using a 5‐point Numeric Rating Scale (NRS) 30 and Schiff Scale (SS), 29 which is an objective scale by using the evaporative (air) sensitivity test by application of air from triple way dental syringe to every labial tooth surface. The sensitivity intensity of each tooth was evaluated immediately, 24 h, 1 week, 2 weeks, and up to 1 month after bleaching.…”

Effect of an experimental desensitizing gel on bleaching-induced tooth sensitivity after in-office bleaching—a double-blind, randomized controlled trial

“…The preventive effect of analgesics and opioids [13,14], anti-inflammatories [15][16][17][18], antioxidants [19], and corticosteroids [20][21][22] has previously been investigated, and they could not mitigate bleaching-induced TS [23]. So far, the most successful approach to reducing TS has been the topical application of desensitizers, such as those containing glutaraldehyde [24,25], potassium nitrate [26,27], and calcium agents [28,29].…”