Association Between -1607 1G/2G Polymorphism of MMP1 and Temporomandibular Joint Anterior Disc Displacement with Reduction

Abstract

<jats:p>Abstract Anterior disc displacement with reduction (DDWR) is considered one of the most common disorders within the temporomandibular joint (TMJ), with a prevalence of 41% in adults. Matrix metalloproteinases play an important role in the degradation of the TMJ and the matrix metalloproteinase 1 (MMP1) 1607 1G/2G polymorphism increases the local expression of MMP1 thus leading to accelerated degradation of the extracellular matrix. The objective of this study was to evaluate the association between the 1607 1G/2G polymorphism of MMP1 gene and DDWR in a group of Mexican individuals from western Mexico. A total of 67 unrelated individuals, between the ages of 18 and 36 years, of both genders, were included in this study. Study participants with DDWR were required to meet the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD), while a second control group of 90 individuals without DDWR were also included. Both groups were required to have paternal and maternal ancestry (grandparents) of the same geographic and ethnic region. Genotypes were determined using the nested PCR technique. The 1G/2G polymorphism was found in 68.7%, followed by 2G/2G in 25.4% and 1G/1G in 6.0% of the cases group. While the prevalence in the control group was 55.5% for the 1G/2G polymorphism, 26.6% for 1G/1G and 17.7% for 2G/2G. An association was found between the 2G allele of the 1607 1G/2G polymorphism of MMP1 gene and the presence of DDWR in the patients of western Mexico.</jats:p>

Genetic overlap between temporomandibular disorders and primary headaches: A systematic review

“…From the included studies, a brief description of the study design and sample is provided, followed by identifying the genes involved in the pathophysiology of either PHD ( Table 3 ) [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] or TMD ( Table 4 ) [81] , [82] , [83] , [84] , [85] , [86] , [87] , [88] , [89] , [90] , [91] , [92] , [93] , [94] ,…”

“… - Patients with a genotype of ESR1 rs1643821 exhibited a decreased probability against anterior disc displacement without reduction; - rs1643821 is associated with susceptibility to the anterior disc displacement without a decrease in European Caucasians. TNF-α (rs1800629) Rosales et al (2020) [85] Case-control study TMD patients with anterior disc displacement with reduction (67); & controls (90) MMP1 (1G/2G, 2G/2G, 1G/1G) - An association between the 2G allele of the 1607 1G/2G SNP of MMP1 gene and the presence of anterior disc displacement with reduction in the patients of Western Mexico was found. - 1607 1G/2G SNP is associated with the development of anterior disc displacement with reduction in Western Mexico patients; - The presence of the 2G allele could be considered as a risk factor for the development of anterior disc displacement with reduction.…”