Haplotypes in BMP4 and FGF Genes Increase the Risk of Peri-Implantitis

Rb, Coelho; M, Villas-Boas Rde; LL, Bonato; Quinelato,; R, Pinheiro Ada; Machado, Aldir Nascimento; Ch, Nunes; Gonçalves, Roberto Calderón; Ar, Vieira; Granjeiro, José Mauro; Casado, Priscila Ladeira

doi:10.1590/0103-6440201600899

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…Clinicians should keep in mind that BMP signaling plays a role in fracture healing and orthodontic tooth movement, when correcting the distal relationship and distal occlusion (Guimarães et al, 2013). An increased risk of peri-implantitis was found in BMP4 haplotypes (Coelho et al, 2016). This must be taken into account when clinicians consider replacing missing teeth by implants.…”

Section: Discussionmentioning

confidence: 99%

Dental and Craniofacial Characteristics in Patients With 14Q22.1-Q22.2 Deletion: A Case Series

Roelandt

Devriendt

Llano-Pérula

et al. 2020

The Cleft Palate-Craniofacial Journal

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This case series is a follow-up report focusing on dental and facial characteristics in patients with a rare microdeletion in chromosome 14q22.1-q22.2. Usually, these patients have severe ocular, brain, and digital abnormalities. However, this case series shows that clinical presentation can be mild. Four relatives spanning 3 generations were diagnosed with a familial autosomal dominant 2.79 Mb microdeletion in chromosome 14q22.1-q22.2. Genetic screening was done by the Bacterial Artificial Chromosome array-comparative genome hybridization and was confirmed by the fluorescence in situ hybridization technique. Dental and craniofacial data were collected from medical files, clinical examinations, clinical photos, panoramic and cephalometric radiographs, and dental casts. Written informed consent for scientific use was obtained for all family members. No larger syndrome could be identified. All cases had similar facial red flag characteristics, consisting of a long face with retrognathia and open mouth relation, associated oral clefts in varying degrees, depressed nasal bridge, delayed tooth development, hypertelorism, and low-set angular ears. The dental casts showed a distal molar occlusion and a lack of space in the dental arches. Developmental delay was noted together with limb defects such as poly- and syndactyly. Microphthalmia and hearing loss were present in the most severe cases. This rare congenital disorder, associated with facial dysmorphia, oral clefts, and tooth agenesis, can remain undiagnosed until adulthood. A family history of short stature, developmental delay, poly- or syndactyly, and micropthalmia are suggestive features. Similar reports help to raise awareness among dental practitioners, leading to an early genetic diagnosis.

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Section: Discussionmentioning

confidence: 99%

Dental and Craniofacial Characteristics in Patients With 14Q22.1-Q22.2 Deletion: A Case Series

Roelandt

Devriendt

Llano-Pérula

et al. 2020

The Cleft Palate-Craniofacial Journal

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“…A recent investigation reported remarkably association with additional candidate genes. Coelho et al investigated the association between peri‐implantitis and bone morphogenetic proteins or fibroblast growth factor because of their involvement in bone remodeling. This study, involving 215 patients, found elements supporting a possible role for bone morphogenetic protein‐6 and fibroblast growth factor‐10 in peri‐implantitis.…”

Section: Genetic Susceptibilitymentioning

confidence: 99%

Molecular tools for preventing and improving diagnosis of peri‐implant diseases

Romanos

Scapoli

2019

Periodontology 2000

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Web: www.carin ci.org | INTRODUC TI ONPeri-implant mucositis and peri-implantitis are inflammatory diseases around dental implants that involve infectious agents and destructive immune responses. Current diagnosis in implantology is based on clinical and radiological observations (Figures 1,2). Molecular tests may augment the clinical and radiological examinations. 1,2 A molecular test can potentially provide an early diagnosis, tailor therapy, check treatment, customize clinical recalls and improve patient compliance.The initial evaluation of a prospective implant patient includes radiographic analysis to assess the status of hard tissues.Microbiological tests may also be warranted to evaluate the type and load of microbial pathogens. Microbial samples can be collected by paper points and then shipped to a laboratory, which can issue a laboratory report in a few days ( Figure 3). Treatment planning including oral hygiene instruction and more complex treatment approaches is then implemented (Figure 4). If surgery is scheduled, a second microbiological test might help determine the efficacy of the pre-surgical oral hygiene measures. Posttreatment, testing might be helpful to determine the efficacy of patient home care in order to refine a customized recall program.To become a valuable tool in daily practice, molecular tests must be easy and rapid to perform, and should provide in a reasonably short time laboratory results that would be readily understood (possibly also by the patient) and relatively inexpensive. Generally, two types of test exist: a screening test, such as a pregnancy test (that is performed by the patient and includes one biomarker) and a laboratory test (that is performed by dental professionals using a standardized sampling protocol to investigate several biomarkers). The laboratory test usually follows the screening test. In medicine and specifically in gynecology, the screening test is usually performed at home and may possibly be evaluated by a specialist, who may request additional tests with specific biomarkers. Dental professionals may perform molecular/microbiological tests in a similar matter to ameliorate the diagnosis and treatment of peri-implant mucositis and peri-implantitis.Molecular tests are best used for treatment planning and for designing a preventive program rather than for rescue operations. 1,2 | INFEC TI ON FAC TOR SIt is commonly accepted that bacteria are major initiators of periimplant mucositis and peri-implantitis as well as of periodontal diseases. It is also well known that periodontitis patients have a higher risk of peri-implant mucositis and peri-implantitis than edentulous subjects. 3,4 Although substantial differences exist in terms of anatomy and physiology between the implant mucosa/bone interface and the periodontium, the bacterial profiles 5,6 and the host immune responses may be quite similar in peri-implantitis and periodontitis. 7The early aim of researchers was to detect bacterial quality and quantity differences between peri-implant mucositis and peri...

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“… There is high level of RANKL/OPG in peri‐implant mucosae of patients with history of chronic periodontitis (Costa et al., ). Haplotypes in BMP4 and FGF genes increase the risk of peri‐implantitis (Coelho et al., ) MMP13 , TIMP2, and TGFB3 gene polymorphisms are associated with Brazilian chronic periodontitis and peri‐implantitis (Junior et al., ). BRINP3 gene has different contribution in chronic periodontitis and peri‐implantitis (Casado et al., ). IL6 gene polymorphism is associated with periodontitis and peri‐implantitis in a Brazilian population (Casado et al., ,b). …”

Section: Periodontitis and Peri‐implant Diseasesmentioning

confidence: 99%

“…and FGF genes increase the risk of peri-implantitis (Coelho et al, 2016) 3. MMP13, TIMP2, and TGFB3 gene polymorphisms are associated with Brazilian chronic periodontitis and periimplantitis .…”

Section: Haplotypes In Bmp4mentioning

confidence: 99%

Dental genetics in Brazil: Where we are

Casado

Quinelato

Cataldo

et al. 2018

Molec Gen & Gen Med

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Dentistry constitutes the basic nucleus of professionals of higher level of health in Brazil with one of the largest concentrations of dentists per capita in the world. However, the genetic in dentistry in Brazil is explored, basically, in research field. Future actions need to be performed in order to deep the whole knowledge about diagnosis and treatment of diseases with genetic basis in dentistry, in Brazil.

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Haplotypes in BMP4 and FGF Genes Increase the Risk of Peri-Implantitis

Cited by 10 publications

References 23 publications

Dental and Craniofacial Characteristics in Patients With 14Q22.1-Q22.2 Deletion: A Case Series

Dental and Craniofacial Characteristics in Patients With 14Q22.1-Q22.2 Deletion: A Case Series

Molecular tools for preventing and improving diagnosis of peri‐implant diseases

Dental genetics in Brazil: Where we are

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