Effect of Growth Hormone in Experimental Tooth Movement

Ribeiro, Jucienne Salgado; Maciel, José Vinicius Bolognesi; Knop, Luégya Amorin Henriques; Machado, Maria Ângela Naval; Grégio, Ana Maria Trindade; Camargo, Elisa Souza

doi:10.1590/0103-6440201302286

Cited by 10 publications

(6 citation statements)

References 23 publications

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“…GH effects were evaluated on PDL and alveolar bone during dental movements in rats receiving 30 N orthodontic forces on the maxillary first molar [ 109 ]. Collagen fibers and the number of osteoclasts in the compression zone are significantly increased while the number of blood vessels is decreased.…”

Section: Gh/igf and Oral Tissue Engineeringmentioning

confidence: 99%

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Koffi

Doublier

Ricort

et al. 2021

Cells

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The GH/IGF axis is a major regulator of bone formation and resorption and is essential to the achievement of normal skeleton growth and homeostasis. Beyond its key role in bone physiology, the GH/IGF axis has also major pleiotropic endocrine and autocrine/paracrine effects on mineralized tissues throughout life. This article aims to review the literature on GH, IGFs, IGF binding proteins, and their respective receptors in dental tissues, both epithelium (enamel) and mesenchyme (dentin, pulp, and tooth-supporting periodontium). The present review re-examines and refines the expression of the elements of the GH/IGF axis in oral tissues and their in vivo and in vitro mechanisms of action in different mineralizing cell types of the dento-alveolar complex including ameloblasts, odontoblasts, pulp cells, cementoblasts, periodontal ligament cells, and jaw osteoblasts focusing on cell-specific activities. Together, these data emphasize the determinant role of the GH/IGF axis in physiological and pathological development, morphometry, and aging of the teeth, the periodontium, and oral bones in humans, rodents, and other vertebrates. These advancements in oral biology have elicited an enormous interest among investigators to translate the fundamental discoveries on the GH/IGF axis into innovative strategies for targeted oral tissue therapies with local treatments, associated or not with materials, for orthodontics and the repair and regeneration of the dento-alveolar complex and oral bones.

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Section: Gh/igf and Oral Tissue Engineeringmentioning

confidence: 99%

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Koffi

Doublier

Ricort

et al. 2021

Cells

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“…After 3 weeks, the retraction range of the canines was 60% higher compared to the control group. 7,8 Other researchers came to similar conclusions, this time testing the action of this vitamin on rats. They noticed an increased number of both osteoclasts and osteoblasts.…”

Section: Parathormonementioning

confidence: 74%

Different Modalities for Accelerating Orthodontic Tooth Movement: A Review of Studies.

Korayem¹,

Malibari²,

Bakhadher³

2019

IJAR

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Technological advancement and the initiation of modern therapeutic methods are constantly changing contemporary orthodontics. More and more orthodontic patients are working adults, who expect satisfactory therapeutic effects as soon as possible, increasing the importance of methods accelerating tooth movement. Aim: The aim of this hypothesis was to review the present literature regarding methods of accelerating tooth movement and reducing the duration of the active phase of therapy. Methods: The methods described were categorized as conservative and surgical. The pharmacological agents used in conservative treatment, such as growth hormone, parathyroid hormone, thyroxine, and vitamin D, are especially worth mentioning. They stimulate osteoclasts to increase resorption through a variety of mechanisms. Effective methods also include physical stimuli, e.g., vibrations or photo bio-modulation. Corticotomy and its modifications based on the regional acceleratory phenomenon (RAP) might prove to be a useful augmentation of orthodontic treatment, especially in adults, including patients with periodontal disease. Conclusion: Tooth acceleration phenomenon is still a relatively new horizon and researchers have yet to seek a single most ideal and prudent technique for the patient. The surgical techniques have most of the human trials and also show very favorable and long term effects adding to the stability and retention of the orthodontic therapy.

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“…The histomorphometric and histological results from the present study suggest that under the experimental conditions and GH concentrations (0.133 mg) investigated, the local administration of GH immobilized in a porcine hemostatic collagen sponge did not improve the healing of critical size calvarial defects in an in vivo rat model. Specimens pertaining to each one of the groups where the GH was used either as a locally administered irrigation solution (AB/GHþ and AB/GHLþ), displayed very few remnants of bone particles from the autogenous ground bone graft, no indication of the presence of the bovine cortical membrane A recently published study [29] investigated the systemic effect of GH over experimental orthodontic teeth movement in a rat model. The results reported have indicated that the utilization of GH delayed the formation of collagen while accelerating and intensifying the bone resorption process.…”

Section: Discussionmentioning

confidence: 99%

Growth hormone effects on healing efficacy, bone resorption and renal morphology of rats: histological and histometric study in rat calvaria

Giovanini

Zielak

Scariot

et al. 2020

Heliyon

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Previous reports demonstrated the utility of systemic application of growth hormone (GH) in the treatment of bone defects. Very few studies correlated bone repair efficacy with hepatic and renal side effects promoted by locally-delivered GH. The objectives of this study were to assess the bone repair properties along with hepatic and renal adverse effects promoted by local application of GH in a rat model. Thirty-two rats were randomly divided (4 groups; n = 8/group), as follows: (i) AB (autogenous bone + local application of saline solution [SS]), (ii) AB+ (autogenous bone + SS local application + SS irrigation), (iii) AB/GH+ (autogenous bone + SS local application + GH irrigation) and (iv) AB/GHL+ (autogenous bone + GH local application + GH irrigation). Critical-sized defects (diameter = 5.0 mm) were surgically created by a single operator in the calvaria of rats. Defects were filled with ground autogenous bone. Defects pertaining to AB+ and AB/GH+ received a mixture of autogenous bone and a SS-saturated (0.02 mL) collagen sponge covered with bovine cortical membrane. Defects in group AB/GHL+, were filled with the same biomaterials saturated with GH (0.02 mL). SS (0.1 mL) or GH (0.1 mL, equivalent to 0.4 IU) were applied locally on alternate days (8 weeks) in animals in groups AB, AB+ and AB/GH+ or AB/GHL+, respectively. Bone repair properties was determined in hematoxylin/eosin-stained slices using traditional histologic and histomorphometric techniques along with optical microscopy and digital image analysis. Statistical differences among groups was determined using Kruskal-Wallis and Tukey post hoc tests (α = 0.05). Histology results indicated that AB and AB+ displayed greater presence of autogenous bone as compared to AB/GH+ and AB/GHL+. Histomorphometric results indicated significantly higher osteoid matrix formation in AB and AB+ when compared to AB/GHL+ ( p = 0.009). Kidneys and livers were found to have their glomeruli preserved in AB and AB+. Strong glomeruli necrosis and large areas of protein deposition were found in AB/GH+. Abnormal small-sized glomeruli were found in AB/GHL+. The utilization of autogenous bone graft associated with local application and irrigation with GH was shown to not improve the bone repair in calvarial critical-sized defects in a rat model.

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Effect of Growth Hormone in Experimental Tooth Movement

Cited by 10 publications

References 23 publications

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

The Role of GH/IGF Axis in Dento-Alveolar Complex from Development to Aging and Therapeutics: A Narrative Review

Different Modalities for Accelerating Orthodontic Tooth Movement: A Review of Studies.

Growth hormone effects on healing efficacy, bone resorption and renal morphology of rats: histological and histometric study in rat calvaria

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