Dynamics of Microbial Colonization of the Oral Cavity in Newborns

Filho, Paulo Nelson; Borba, Izabela Gonçalves; Mesquita, Késsia Suênia Fidelis de; Silva, Léa Assed Bezerra da; Queiroz, Alexandra Mussolino de; Silva, Léa Assed Bezerra

doi:10.1590/0103-6440201302266

Cited by 50 publications

(63 citation statements)

References 24 publications

(33 reference statements)

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“…First, we found 20 kinds of oral flora, the most frequent of which were Streptococcus , MRSA, and CNS. An earlier study also found Staphylococcus and Streptococcus to be major flora in the oral mucus of healthy newborns, as early as 10 min to 53 hr after birth (Nelson‐Filho et al, ). Despite the lack of research on oral flora in high‐risk newborns, including infants born prematurely, our findings suggest the similarity of oral flora types in newborns regardless of their clinical characteristics during early postnatal period.…”

Section: Discussionmentioning

confidence: 89%

Flora colonization and oral care in high‐risk newborns

Ahn

Jun

Kim

et al. 2019

Specialist Pediatric Nursing

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Purpose A randomized intervention study was conducted to explore the impact of oral care with sterile normal saline to oral flora colonization of high‐risk newborns at the third day after birth. Design and Methods Ninety‐two newborns were allocated to either intervention or control group. After obtaining oral secretion for prepoint data, the intervention group received oral care with sterile normal saline only. Oral secretions for postpoint data were obtained 8 hr after the prepoint. Total 179 specimens were obtained during the study period. Results Among the total 92 newborns, 44.6% were female and 57.6% were premature. Mean gestational age and weight was 35.9 ± 3.2 weeks and 2,545 ± 697.5 g. The most common colonized flora included Streptococcus (26.3%), methicillin‐resistant Staphylococcus aureus (MRSA, 16.2%), and coagulase‐negative Staphylococci (CNS, 13.4%). The oral care with normal saline did not change the number of flora type of newborns. The statistic results were not significant by group (F = 0.918, p = 0.514), time (F = 0.322, p = 0.672), and the interaction between time and group (F = 0.519, p = 0.472). Practice Implications Oral care with sterile saline did not change oral flora colonization among high‐risk newborns at early period of life. This intervention can be safely delivered to high‐risk newborns when they are at risk of infection and particularly breast milk is not available.

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Section: Discussionmentioning

confidence: 89%

Flora colonization and oral care in high‐risk newborns

Ahn

Jun

Kim

et al. 2019

Specialist Pediatric Nursing

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“…The oral environment is sterile at birth, but the introduction of microorganisms can occur during labor, through microbial invasion of amniotic cavity and aspiration of contaminated amniotic fluid, or by contact with microorganisms present in the birth canal or genital secretions or maternal feces (9,18,19). Thus, the oral cavity can harbor various microbial species, including microorganisms of the Enterobacteriaceae and Pseudomonadaceae multiresistant families.…”

Section: Discussionmentioning

confidence: 99%

“…These microorganisms can survive in the environment and also temporarily on the hands of persons handling newborns, making the child-child transmission easier. Another important risk factor for NB infections is the limited protection of the immune system during this period of life (8,9). These and other pathogenic microorganisms may remain viable in areas associated and non-associated with the newborn, increasing the risk of infection outbreaks (9).…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Sensitivity of Bacilli and Pseudomonas in the Newborn’s Oral Cavity

et al. 2017

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The aim of this study was to isolate Enterobacteria and Pseudomonas from the oral cavity of hospitalized newborns (NB) and determine their prevalence and the sensitivity profile to most commonly used antibiotics for this age group. Samples from the oral cavity of NB from 24 to 48 h age were collected using swabs. The samples were inoculated on MacConkey agar, incubated and the colonies counted and identified. For each strain, the minimum inhibitory concentration (MIC) was determined using agar dilution test. Tests for enterobacteria producing extended spectrumβ-lactamases (ESBL) were performed using agar diffusion. Descriptive statistics was used for data analysis. Two of the isolated strains were submitted to the susceptibility test in biofilm. Of the collected samples, 8% presented Enterobacteria (mean of 6,141 CFU/mL) and no Pseudomona species was isolated. Positive samples were from NB in accommodation set or in the NB nursery. Enterobacter was the most prevalent genus and some strains were resistant to ampicillin, gentamicin and cephalothin. No ESBL strain was detected. Microorganisms in biofilms were resistant to all antibiotics, with concentrations four times higher than MIC. The presence of enterobacteria in the oral cavity of newborns, especially some strains resistant to normally used antibiotics, warns to the need for care to avoid the early colonization of this niche and the occurrence of a possible hospital infection in this age group.P r e v a l e n c e a n d S e n s i t i v i t y o f B a c i l l i a n d P s e u d o m o n a s i n t h e N e w b o r n ' s O r a l C a v i t y

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“…Several years ago it was shown that the mouth microbiota evolves with age. Colonization begins at birth (Prince et al 2014) when dynamic microbial colonization of the oral cavity begins (Nelson-Filho et al 2013). The profile of the predominant phylum evolves during childhood and youth and has almost stabilized by adulthood (Human Microbiome Project Consortium 2012).…”

Section: Agingmentioning

confidence: 99%

The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract

et al. 2017

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Many studies show that the human microbiome plays a critical role in the chronic pathologies of obesity, inflammatory bowel diseases, and diabetes. More recently, the interaction between cancer and the microbiome has been highlighted. Most studies have focused on the gut microbiota because it represents the most extensive bacterial community, and the body of evidence correlating it with gut syndromes is increasing. However, in the strict sense, the gastrointestinal (GI) tract begins in the oral cavity, and special attention should be paid to the specific flora of this cavity. This study reviewed the current knowledge about the various microbial ecosystems of the upper part of the GI tract and discussed their potential link to carcinogenesis. The overall composition of the microbial communities, as well as the presence or absence of "key species", in relation to carcinogenesis is addressed. Alterations in the oral microbiota can potentially be used to predict the risk of cancer. Molecular advances and the further monitoring of the microbiota will increase our understanding of the role of the microbiota in carcinogenesis and open new perspectives for future therapeutic and prophylactic modalities.Key words: upper aerodigestive, microbiome, oral cavity, carcinogenesis.Résumé : Plusieurs études montrent que le microbiome humain joue un rôle essentiel dans les pathologies chroniques que sont l'obésité, les maladies inflammatoires de l'intestin et le diabète. Plus récemment, l'interaction entre le cancer et le microbiome a été soulignée. La plupart des études se sont concentrées sur le microbiote intestinal car il représente la communauté bactérienne la plus étendue, et l'ensemble des preuves le corrélant avec les syndromes de l'intestin est en croissance. Cependant, au sens strict, le tractus gastro-intestinal (GI) commence dans la cavité orale et une attention spéciale devrait être portée à la flore spécifique de cette cavité. Cette étude fait la synthèse des connaissances actuelles relatives à divers écosystèmes microbiens de la partie supérieure du tractus GI et discute de leur lien potentiel à la carcinogenèse. La composition globale des communautés microbiennes, de même que la présence ou l'absence « d'espèces clés » relativement à la carcinogenèse sont soulevées. Des modifications du microbiote oral peuvent potentiellement être utilisées pour prédire les risques de cancer. Les percées moléculaires et la surveillance accrue du microbiote accroitront notre compréhension du rôle du microbiote dans la carcinogenèse et ouvriront de nouvelles perspectives en vue de modalités thérapeutiques et prophylactiques futures. [Traduit par la Rédaction]

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Dynamics of Microbial Colonization of the Oral Cavity in Newborns

Cited by 50 publications

References 24 publications

Flora colonization and oral care in high‐risk newborns

Flora colonization and oral care in high‐risk newborns

Prevalence and Sensitivity of Bacilli and Pseudomonas in the Newborn’s Oral Cavity

The oral cavity microbiota: between health, oral disease, and cancers of the aerodigestive tract

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