Pulp Tissue Dissolution Capacity of Sodium Hypochlorite Combined with Cetrimide and Polypropylene Glycol

Abstract

This study evaluated the influence of the addition of cetrimide and polypropylene glycol to sodium hypochlorite (NaOCl) on its capacity to dissolve pulp tissue. Bovine pulp fragments with standardized weight and volume were immersed for 5, 15 and 30 min in 2 mL of NaOCl and Hypoclean (NaOCl added with cetrimide and polypropylene glycol) solutions at 5.25%, 2.5%, 1%, 0.5% and 0.25% and afterwards re-weighted. Distilled water was used as a control. The percentage of tissue loss was considered for statistical analysis (univariate ANOVA, SPSS, v. 17.0) at 5% significance level. There was no tissue dissolution in the control group. NaOCl added with surfactants (Hypoclean) dissolved more pulp tissue (p<0.05) than NaOCl alone. Tissue dissolution was directly dependent on the concentration of solutions (p<0.05), and also on the time range (p<0.05). The combination of NaOCl at high and low concentrations with the surfactants cetrimide and polypropylene glycol increased significantly its capacity to dissolve pulp tissue.

Bovine Pulp Tissue Dissolution Ability of Irrigants Associated or Not to Ultrasonic Agitation

“…Furthermore, bovine pulps have been used to test tissue dissolution capacity of several endodontic irrigants (11,19,20).…”

“…De Almeida et al (11) reported that the time of bovine pulp dissolution was reduced when NaOCl was associated with cetrimide. However, in this study, there was no significant difference in dissolution time when these two irrigants were associated.…”

“…It has been used in combination with various irrigating solutions (NaOCl, chlorhexidine, EDTA, etc.) to reduce surface tension and increase the penetration in the root canal system (8,11).…”

Evaluation of Microbial Reduction in Root Canals Instrumented with Reciprocating and Rotary Systems

“…Kako se pokazalo u ovom istraživanju i u istraživanji-ma Gulsahija i suradnika (4), Almeide i njegovih kolega (18) i Shantiaee i njegova tima (19), NaOCl ima širok spektar antimikrobne aktivnosti, može razgraditi organski materijal te djeluje kao lubrikant tijekom instrumentacije kanala. Unatoč tomu nema zajedničkog stajališta kad je riječ o optimalnoj koncentraciji, duljini izloženosti i temperaturi natrijeva hipoklorita za kliničku primjenu u endodonciji.…”

Avaliação da capacidade de dissolução de tecido pulpar bovino pelo hipoclorito de sódio em diferentes concentrações

“…Nakamura et al 12 , em 1985, observaram maior velocidade de dissolução na concentração 10%. Siqueira et al 1 , Koskinen et al 13 , Spanó et al 10 e Hand et al Como o hipoclorito de sódio tem uma tensão superficial elevada, pode-se adicionar um agente umectante a ele, para que melhore a sua capacidade de molhamento, entrando em contato, assim, mais rapidamente com toda a polpa do sistema de canais radiculares e aumentando, dessa forma, a sua capacidade de solvência 14 .…”