Factors associated with time free of oral candidiasis in children living with HIV/AIDS, São Paulo, Brazil

Abstract

Fatores associados ao tempo livre de candidíase oral em crianças vivendo com HIV/AIDS, São Paulo, Brasil Factores asociados al tiempo libre y la candidiasis oral en niños que viven con VIH/SIDA, São Paulo, Brasil

Principais manifestações bucais em pacientes pediátricos HIV positivos e o efeito da terapia antirretroviral altamente ativa

“…Early identification of oral manifestations, which usually are the first signs of this infection or its progression in children 2 , may assist in choosing appropriate therapy and reducing its morbidity 6 . Immunosupressed patients are more susceptible to opportunistic infections, especially those that affect the oral cavity, such as oral candidiasis 8 . This problem becomes worse when it comes to HIV-positive pediatric patients because they present an immature immune system that makes them more prone to severe immunosuppression and rapid disease progression 2,6 .…”

“…A wide variety of oral lesions in HIV-infected pediatric patients are reported in the literature, such as: candidiasis 8,[10][11][12] , gingivitis [12][13][14] , oral hairy leukoplakia 9,13 ,Kaposi's sarcoma 5,10,15 ,parotid enlargement 1,4,14,16 , herpes simplex 1,2 .This data also reveal divergence of information regarding which ones are the most frequent oral manifestations and how the antiretroviral therapies act on them. For this reason, this present study aims to identify the main oral lesions affecting pediatric patients with HIV, as well as the effects of ART and HAART on said lesions.…”

Pediatric Oral Manifestations of HIV- A Case Report with Review

“…HIV infection currently affects more than 2 million children under the age of 15 years old worldwide and it is associated with numerous life-long comorbidities for this population [6][7] . Immunosuppression leads to opportunistic infections, mainly that affect the oral cavity, such as oral candidiasis 8 where as in pediatric HIVpositive patients this problem become more worse due to immature immune system that leads rapid disease progression 2-6 Different types of oral lesions in HIV-infected pediatric patients such as: candidiasis 8 , gingivitis, oral hairy leukoplakia, Kaposi's sarcoma parotid enlargement and herpes simplex. HIV-infected patients have demonstrated an increased frequency and severity of atypical periodontal disease.…”

Sobrevida em crianças e adolescentes infectados via vertical pelo hiv e fatores associados ao óbito

“…21 Considering the significant association between opportunistic infections and evolution to death, verified in the present research, it is worth mentioning that, according to the consensus of scholars, these infections are usually recurrent among HIV infected 19 Feira de Santana findings corroborate a survey carried out in São Paulo with children and adolescents aged 0 to 12 years who were vertically infected with HIV, where the survival time was observed to be longer, in the absence of a specific opportunistic infection (candidiasis), especially in those using ART. 22 Researchers point to this infection as an important risk factor for death, even before the fall in CD422 levels, and may manifest itself with functional alterations of the skin and mucosa 23 .…”