This article explores intervention and inclusion strategies for syphilis control in vulnerable populations, employing a bibliographic and quantitative methodological approach. Syphilis, a sexually transmitted infection of significant global concern, disproportionately affects marginalized groups due to socioeconomic factors and barriers to accessing healthcare services. Studies indicate that implementing health education programs and promoting regular testing are crucial to reducing syphilis incidence in these populations (Smith, 2020). Additionally, community initiatives focused on increasing awareness and access to treatment have proven effective in addressing this public health issue (Johnson & Miller, 2019). Quantitative data reinforce the need for an integrated and inclusive approach involving healthcare professionals, community organizations, and public policies, as essential for syphilis control in vulnerable populations.