HIV/AIDS, tuberculose e tabagismo no Brasil: uma sindemia que exige intervenções integradas

Novotny, Thomas E.; Soares, Elizabeth; Sereno, Andrea B.; Kiene, Susan M.

doi:10.1590/0102-311x00124215

Cited by 16 publications

(19 citation statements)

References 13 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Regarding smoking, it was evidenced mainly in infected males (13.5%). Tobacco use has been associated with a greater likelihood of latent tuberculosis infection progressing to the active form, as well as being associated with greater difficulties in adherence to treatment, resistance phenomena and relapse cases [32]. It is believed that smoking may contribute to the development of tuberculosis for two main reasons: first, due to nicotine's ability to act on α7-nicotinic receptors, thus decreasing macrophage tumor necrosis factor (TNF-α) production, hindering the recruitment of neutrophils, monocytes and decreasing the production of other cytokines that contribute to greater microbicidal activity in both dendritic cells and macrophages.…”

Section: Resultsmentioning

confidence: 99%

Profile of tuberculosis patients in Natal-RN, Brazil, from 2010 to 2018: a documentary study

Júnior

Alves

Farias³

et al. 2019

Sci. Plena

View full text Add to dashboard Cite

The present study aimed to elucidate the epidemiological profile of tuberculosis patients in Natal-RN between the years 2010 and 2018. This was an epidemiological, retrospective and documentary study, in which the recovery of the secondary data occurred from the "Departamento de Informática do Sistema Único de Saúde (DATASUS)" in Brazil. The following variables were studied: year of notification, gender, age, schooling, area of residence, ethnicity and factors that facilitate the onset of tuberculosis. Statistical association was performed using the Chi-Square test. In the year 2011, the highest percentage of notifications for tuberculosis was received (12.4%) in Natal-RN. The profile of the affected individuals was predominantly male (69.5%), between 20 and 39 years of age (43.8%), low educational levels (41.3%), mulattoes (68.2%) and urban residents (94.1%). When gender was associated with factors that facilitate the onset of tuberculosis, it was observed that males presented higher percentages of positivity for Human Immunodeficiency Virus (HIV) (16.3%), Acquired immunodeficiency syndrome (AIDS) (15.8%), alcoholism (34%) and smoking (13.5%), while in females the highest rates of this correlation were with Diabetes mellitus (10.4%). In addition, a statistically significant association was found between gender with tobacco and alcohol consumption (<0.001) and with the presence of diabetes and Aids (<0.001). The data found in this study may serve as an auxiliary for developing more specific public policies for those most susceptible to tuberculosis in Natal-RN.

show abstract

Section: Resultsmentioning

confidence: 99%

Profile of tuberculosis patients in Natal-RN, Brazil, from 2010 to 2018: a documentary study

Júnior

Alves

Farias³

et al. 2019

Sci. Plena

View full text Add to dashboard Cite

show abstract

“…We acknowledge that the profile of those affected is closely related to the tuberculosis treatment outcome; in the case of the presence of multi-morbidity, there is an increased risk of obtaining the unfavorable outcome (5,(7)(8)(9) . In this study, multimorbidity was present in 37% of the cases, with smoking (31.2%) and HIV (17.7%) being the most common morbidities, as identified by other researchers (9) .…”

Section: Discussionmentioning

confidence: 99%

“…Among the clinical conditions, studies show that the presence of another disease is associated with the unfavorable outcomes of the tuberculosis treatment, among which are HIV, diabetes mellitus and chronic kidney conditions (5,(8)(9) . However, no studies were found that observed the relationship between multimorbidity and the outcome of the treatment for the disease.…”

Section: Introductionmentioning

confidence: 99%

Relationship between multimorbidity and the outcome of the treatment for pulmonary tuberculosis

Soares

Spagnolo

Tomberg

et al. 2020

Rev. Gaúcha Enferm.

View full text Add to dashboard Cite

ABSTRACT Objective: To analyze the influence of multimorbidity on the treatment outcome of new cases of pulmonary tuberculosis. Method: A population-based analytical study, using secondary data, collected from the database of the Notification Disease Information System, of new cases of pulmonary tuberculosis in the state of Rio Grande do Sul between 2013 and 2016. The relationship between multimorbidity and the outcome was analyzed with Multinomial Logistic Regression. Results: Multimorbidity was present in 37.0% of the cases. Of these, the Relative Risk (RR) was 1.7 for treatment abandonment and 2.9 for death. HIV had an RR of 2.1 for dropout and of 3.9 for death. The higher the number of comorbidities, the higher the RR for unfavorable outcomes. Conclusion: Multimorbidity influences on unfavorable outcomes of the treatment for tuberculosis.

show abstract

“…According to several studies, retroviral anti-HIV treatment can be classified into 3 distinct pharmacological forms of action with their chronological order in the treatment history of those infected: in 1991 the nucleoside RT inhibitors, 1995 the protease inhibitors and in 1996 the nonnucleoside inhibitors of RT (Nunes, Caliani, Nunes & Mello, 2015;Novotny, Hendrickson, Soares, Sereno, & Kiene, 2017;Bittencourt et al, 2015). The Food and Drug Administration (FDA) also adds integrase inhibitors, fusion inhibitors and CCR5 inhibitors (Lozano et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Molecular Docking of Fructose-Derived Nucleoside Analogs Against Reverse Transcriptase of Hiv-1

Monteiro

Scotti

2019

Proceedings of MOL2NET 2019, International Conference on Multidisciplinary Sciences, 5th Edition

View full text Add to dashboard Cite

AIDS is a chronic infection that compromises the immune system of the individual infected with HIV. HIV is a retrovirus, that is, it has RNA as a genetic material, and needs the action of reverse transcriptase (RT) to multiply. A nucleoside is formed by the bond between a carbohydrate and a nitrogenous base that is inserted into the genetic material preventing multiplication. This work consists of a computational analysis through Molecular Docking in order to predict the potential inhibitory activity of RT from a series of 24 nucleoside analogs derived from fructopyranose compared to the bioactive molecules already inserted in the anti-HIV treatment. For this study 36 molecules were designed in ChemDraw Ultra 12.0 to obtain its 2D structural formula. Then the molecule was optimized MM + and AM1 using HyperChemTM (Release 8.0.6 for Windows). Finally, the enzyme RT in PBD (PDB ID 1REV) was selected and in Molegro Virtual Docking 6.0 anchorage was performed. It is possible to conclude that some molecules presented favorable energies for the formation of the ligand-enzyme complexes, as well as the presence of interactions with amino acid residues common to known inhibitors.

show abstract

HIV/AIDS, tuberculose e tabagismo no Brasil: uma sindemia que exige intervenções integradas

Cited by 16 publications

References 13 publications

Profile of tuberculosis patients in Natal-RN, Brazil, from 2010 to 2018: a documentary study

Profile of tuberculosis patients in Natal-RN, Brazil, from 2010 to 2018: a documentary study

Relationship between multimorbidity and the outcome of the treatment for pulmonary tuberculosis

Molecular Docking of Fructose-Derived Nucleoside Analogs Against Reverse Transcriptase of Hiv-1

Contact Info

Product

Resources

About