Comparison of factors associated with leukemia and lymphoma mortality in Brazil

Gouveia, Marcela de Sá; Batista, Jessica Keyla Matos; Passos, Taciana Silveira; Prado, Beatriz Santana; Siqueira, Carlos Eduardo; Almeida-Santos, Marcos Antônio

doi:10.1590/0102-311x00077119

Cited by 6 publications

(5 citation statements)

References 31 publications

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“…Balmant et al 33 noticed a small decline in mortality rates from lymphomas among adolescents and young adults, but only in the South and Southeast regions; in the North and Northeast regions, there was a significant increase trend for both lymphomas and leukemias. Similarly, Gouveia et al 7 showed higher death rates from leukemias and lymphomas in the South and Southeast regions compared to the others. It is noteworthy that, despite improvements in treatment and access to early diagnosis, these findings might reflect regional inequalities and barriers to timely diagnosis and treatment.…”

Section: Discussionmentioning

confidence: 78%

“…The downward trend seen among younger people in Brazil, both from lymphoma and leukemia, is in line with international studies that showed a downward trend in the Americas 30,31 and Europe 32 . By the same token, Gouveia et al 7 , in a study on factors associated with mortality from leukemia and lymphoma in Brazil, found a greater increase in the risk of death associated with age in patients with lymphomas.…”

Section: Discussionmentioning

confidence: 96%

“…In a study on the number of deaths in Brazil between 2010 and 2016, deaths from leukemias and lymphomas were found to occur predominantly among men and people of the white race/skin color. Older age (>60 years for leukemias and >70 years for lymphomas) was also found to be associated with higher mortality rates 7 .…”

Section: Introductionmentioning

confidence: 99%

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Mortality trend and analysis of potential years of life lost due to leukemia and lymphoma in Brazil and Mato Grosso

Soares

Melanda

Neto

et al. 2022

Rev. bras. epidemiol.

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Objective: To estimate the mortality trend and to analyze the potential years of life lost (PYLL) due to leukemias and lymphomas in Brazil and Mato Grosso, from 2001 to 2019. Methods: Time-series study on deaths from leukemias and lymphomas with data obtained from the Mortality Information System. Trends were calculated by age group by the Joinpoint regression method, using calendar year as regressor variable, estimated annual percentage change (APC) and mean annual percentage change, considering 95% confidence intervals. PYLL rates were collected from the Cancer Mortality Atlas. Results: In Brazil, the mortality rate trend remained stable for both diseases in the period: leukemias (APC=0.2; 95%CI 0.0–0.3) and lymphomas (APC=0.2; 95%CI 0.4–0.1). In Mato Grosso state, the rate for leukemias was also stable (APC=0.3; 95%CI 1.0–1.6). For lymphomas, the trend was ascendant (APC=2.3; 95%CI 0.5–4.2), but descending among people younger than 59 years. For leukemias, PYLL rates were 64 and 65/100,000 in Brazil and Mato Grosso, respectively. For lymphomas, 27 and 22/100,000, respectively, with the highest rates found among males. Conclusion: The behavior of mortality rates from leukemia and lymphoma in Mato Grosso was different from that observed nationally, with an upward trend for lymphomas and no differences between age groups for both diseases. PYLL rates for leukemias were similar, while for lymphomas they were higher among men and lower in Mato Grosso when compared to Brazil.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 96%

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Mortality trend and analysis of potential years of life lost due to leukemia and lymphoma in Brazil and Mato Grosso

Soares

Melanda

Neto

et al. 2022

Rev. bras. epidemiol.

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“… 41 On the other hand, the study conducted in Brazil revealed that older age, male gender and white race were associated with higher mortality in lymphoma patients. 42 Therefore, effective interventional strategies should be implemented among comorbid and advanced-stage patients to reduce mortality and extend survival time among all the selected malignancies in the study setting.…”

Section: Discussionmentioning

confidence: 99%

Treatment Outcomes and Its Associated Factors Among Adult Patients with Selected Solid Malignancies at Kenyatta National Hospital: A Hospital-Based Prospective Cohort Study

Degu¹,

Terefe²,

Some³

et al. 2022

CMAR

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Introduction The treatment outcome of cancer is poor in the African setting due to inadequate treatment and diagnostic facilities. However, there is a paucity of data on solid cancers in Kenya. Hence, this study aimed to investigate the treatment outcomes and its determinant factors among adult patients diagnosed with selected solid malignancies at Kenyatta National Hospital (KNH). Materials and Methods A prospective cohort study was employed at the Oncology Department of KNH from 1 st July 2020 to 31 st December 2021. All new patients with a confirmed diagnosis of lymphoma, prostate cancer and breast cancer were studied. A consecutive sample of 99 breast cancer, 50 lymphomas, and 82 prostate cancer patients was included in the study. Semi-structured questionnaires consisting of socio-demographics, clinical characteristics, and quality of life were employed to collect the data. All enrolled patients were followed prospectively for 12 months. Treatment outcomes were reported as mortality, cancer-specific survival and health-related quality of life. The data were entered and analyzed using the SPSS 20.0 statistical software. Survival outcomes and its predictors were evaluated using the Kaplan–Meier analysis and Cox regression analyses, respectively. Results The study showed that the mortality rate among breast and prostate cancer patients was 3% and 4.9%, respectively. In contrast, the mortality rate was 10% among lymphoma patients. Most of the patients had partial remission and a good overall global health-related quality of life. Older age above 60 years, co-morbidity, distant metastasis and advanced stages of disease were significant predictors of mortality. Conclusion Although the mortality was not high at 12 months, only a few patients had complete remission. For many patients, the disease was progressing, despite 12-month mortality was not high. Therefore, longer follow-up will be required to report cancer mortality accurately. In addition, most of the patients had a good overall global health-related quality of life.

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“…In general, this disease affects a group of people aged 67 years and about 30% of patients are over 75 years old. Many experts are concerned about AML because the prognosis worsens with age and accounts for 40% of patient fatalities [1].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic implication of Pleurotus ostreatus on microRNAs expression in acute myeloid leukemia: A systematic review

Lesmana¹,

Pawestri²,

Ujianto³

et al. 2023

World J. Adv. Res. Rev.

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Until now, the modality of choice for patients with acute myeloid leukemia (AML) is chemotherapy. However, chemotherapy has resulted in severe side effects, especially for AML patients aged over 60 years. In addition, cases of multidrug resistance (MDR) have been reported. Pleurotus ostreatus or oyster mushroom has been widely known to possess anticancer effects. The effect might be elicited by its active ingredients. On the other hand, miRNA as a therapeutic target is thought to interact with the active compounds of Pleurotus ostreatus, thus making it a potential complementary treatment for AML. This review was conducted to determine the effect of the active ingredients in Pleurotus ostreatus through their mechanism of action on certain miRNAs. The review was conducted using 49 literatures that have passed the quality assessment using the CRAAP criteria and the JBI checklist. The literature search was carried out using 4 databases, including PubMed, Research Gate, ProQuest, and Science Direct. The systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. The results of the systematic review were synthesized in a narrative review without using statistical tests. In summary, at the molecular level, the active compounds in Pleurotus ostreatus can regulate several miRNAs that affect the proliferation and apoptosis of leukemia cells. In the future, it is necessary to carry out molecular and clinical analysis regarding the relationship between the active compounds of Pleurotus ostreatus and the expression of AML-related miRNAs.

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Comparison of factors associated with leukemia and lymphoma mortality in Brazil

Cited by 6 publications

References 31 publications

Mortality trend and analysis of potential years of life lost due to leukemia and lymphoma in Brazil and Mato Grosso

Mortality trend and analysis of potential years of life lost due to leukemia and lymphoma in Brazil and Mato Grosso

Treatment Outcomes and Its Associated Factors Among Adult Patients with Selected Solid Malignancies at Kenyatta National Hospital: A Hospital-Based Prospective Cohort Study

Therapeutic implication of Pleurotus ostreatus on microRNAs expression in acute myeloid leukemia: A systematic review

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