What matters most?: evidence-based findings of health dimensions affecting the societal preferences for EQ-5D health states

Andrade, Mônica Viégas; Noronha, Kenya; Maia, Ana Carolina; Kind, Paul

doi:10.1590/0102-311x00021113

Cited by 9 publications

(7 citation statements)

References 31 publications

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“…The mean QoL value obtained by indirect measurement with the EQ-5D (0.6878 ± 0.0109) corresponds to the mean values of the valuation parameters (-0.235 to 0.869) found by Andrade et al [25] in the general population of Minas Gerais, which had 5% DM patients. Males presented lower minimum values than females and a greater standard deviation.…”

Section: Discussionsupporting

confidence: 75%

Quality of life of patients with Diabetes Mellitus Types 1 and 2 from a referal health centre in Minas Gerais, Brazil

Mata

Álvares

Diniz

et al. 2016

Expert Review of Clinical Pharmacology

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This version is available at https://strathprints.strath.ac.uk/55487/ Strathprints is designed to allow users to access the research output of the University of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may not engage in further distribution of the material for any profitmaking activities or any commercial gain. You may freely distribute both the url (https://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge.Any correspondence concerning this service should be sent to the Strathprints administrator: strathprints@strath.ac.ukThe Strathprints institutional repository (https://strathprints.strath.ac.uk) is a digital archive of University of Strathclyde research outputs. It has been developed to disseminate open access research outputs, expose data about those outputs, and enable the management and persistent access to Strathclyde's intellectual output. 1 QUALITY OF LIFE OF PATIENTS WITH DIABETES MELLITUS TYPES 1 AND 2 FROM A REFERRAL HEALTH CARE CENTER IN MINAS GERAIS, BRAZIL.

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Section: Discussionsupporting

confidence: 75%

Quality of life of patients with Diabetes Mellitus Types 1 and 2 from a referal health centre in Minas Gerais, Brazil

Mata

Álvares

Diniz

et al. 2016

Expert Review of Clinical Pharmacology

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“…Andrade and collaborators conducted a study using EQ-5D-3L in Brazilian general population. The descriptive analysis showed the following frequencies of patients that presented no problems: mobility (91.23%), self-care (97.59%), usual activities (89.85%), pain/discomfort (57.71%) and anxiety/depression (64.92%) (40) . Thus, except for self-care, HCV patients seem to present higher impairment in HRQoL in all EQ-5D-3L dimensions as compared to the Brazilian general population.…”

Section: Discussionmentioning

confidence: 99%

Hepatitis C in the Brazilian Public Health Care System: Burden of Disease

Castelo

Mello

Teixeira

et al. 2018

Arq. Gastroenterol.

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BACKGROUND: Infection by hepatitis C virus is one of the leading causes of chronic hepatitis C and cause severe burden for patients, families and the health care system. OBJECTIVE: The aims of this research were to assess the severity of liver fibrosis, comorbidities and complications of hepatitis C virus; to examine health-related quality of life (HRQoL), productivity loss and resource use and costs in a sample of Brazilian chronic hepatitis C, genotype 1, patients. METHODS: This was a cross-sectional multicenter study performed in genotype-1 chronic hepatitis C patients to assess disease burden in the Brazilian public health care system between November 2014 and March 2015. Patients were submitted to a liver transient elastography (FibroScan) to assess liver fibrosis and answered an interview composed by a questionnaire specifically developed for the study and three standardized questionnaires: EQ-5D-3L, HCV-PRO and WPAI:HepC. RESULTS: There were 313 subjects enrolled, with predominance of women (50.8%), caucasian/white (55.9%) and employed individuals (39.9%). Mean age was 56 (SD=10.4) years old. Moreover, 42.8% of patients who underwent FibroScan were cirrhotic; the most frequent comorbidity was cardiovascular disease (62.6%) and the most frequent complication was esophageal varices (54.5%). The results also showed that “pain and discomfort” was the most affected HRQoL dimension (55.0% of patients reported some problems) and that the mean HCV-PRO overall score was 69.1 (SD=24.2). Regarding productivity loss, the most affected WPAI:HepC component was daily activity (23.5%) and among employed patients, presenteeism was more frequent than absenteeism (18.5% vs 6.5%). The direct medical costs in this chronic hepatitis C sample was 12,305.72USD per patient in the 2 years study period; drug treatment costs represented 95.9% of this total. CONCLUSION: This study showed that most patients are cirrhotic, present high prevalence of cardiometabolic diseases and esophageal varices, reduced HRQoL mainly in terms of pain/discomfort, and work productivity impairment, especially presenteeism. Additionally, we demonstrated that hepatitis C virus imposes an economic burden on Brazilian Health Care System and that most of this cost is due to drug treatment.

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“…44 In Brazil, only recently EQ-5D and SF-6D were cross-cultural adapted and validated, as well as societal preferences weights were estimated. [45][46][47][48] The difficulty to derive a valid QALY measure is even greater for pediatric populations, because a valid and reliable preference-based measure of utility for child health states does not exist, and the novel approaches are still under methodological investigation. 41,49 HEEs of vaccination usually incorporate only health benefits (reduction in morbidity and mortality) and averted medical spending, undervaluing the vaccines.…”

Section: Discussionmentioning

confidence: 99%

A systematic review of health economic evaluations of vaccines in Brazil

Sartori

Rozman

Decimoni

et al. 2017

Human Vaccines & Immunotherapeutics

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Methods: Systematic review of the literature. We searched multiple databases. Two researchers independently selected the studies and extracted the data. The methodological quality of individual studies was evaluated using CHEERS items. Results: Twenty studies were reviewed. The most evaluated vaccines were pneumococcal (25%) and HPV (15%). The most used types of HEE were cost-effectiveness analysis (45%) and cost-utility analysis (20%). The research question and compared strategies were stated in all 20 studies and the target population was clear in 95%. Nevertheless, many studies did not inform the perspective of analysis or data sources. Conclusions: HEE of vaccines in Brazil has increased since 2008. However, the studies still have methodological deficiencies.

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What matters most?: evidence-based findings of health dimensions affecting the societal preferences for EQ-5D health states

Cited by 9 publications

References 31 publications

Quality of life of patients with Diabetes Mellitus Types 1 and 2 from a referal health centre in Minas Gerais, Brazil

Quality of life of patients with Diabetes Mellitus Types 1 and 2 from a referal health centre in Minas Gerais, Brazil

Hepatitis C in the Brazilian Public Health Care System: Burden of Disease

A systematic review of health economic evaluations of vaccines in Brazil

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