Introduction: Costs, length of hospital staying and morbidity are frequently and significantly
increased as a result of infections and other complications following surgical
procedure for gastrointestinal tract cancer. Recently, improving host defence
mechanisms have become a target of interest. Immunonutrition aims at improving
immunity, most likely providing key nutrients to maintain T-lymphocyte and other
host defence. Aim : To evaluate the immunonutrition in cancer patients who are operated by digestive
diseases and assess the cost-effectiveness of this supplementation. Methods:This study consisted of a systematic review of the literature based on reference
analyses retrieved from current databases such as PubMed, Lilacs and SciELO. The
search strategy was defined by terms related to immunonutrition [immunonutrition,
arginine, omega-3 and nucleotides] in combination with [costs, cost-effective and
cost-effectiveness] as well as [gastrointestinal cancer surgery, oesophageal,
gastric or pancreatic surgery] in English, Portuguese or Spanish language. For
cost analyses, currencies used in the manuscripts were all converted to American
dollars (US$) in order to uniform and facilitate comparison. Six prospective
randomized studies were included in this review. Conclusion:The cost-effectiveness was positive in most of studies, demonstrating that this
diet can significantly reduce hospital costs in the North hemisphere. However,
similar studies needed to be carried to determine such results among us.