Using data from schizophrenia outcome study to estimate the time to treatment outcome and the early-response cut-off score that predicts outcome at week 16

Uchenna, Onu Justus; Ohaeri, Jude U.

doi:10.1590/0101-60830000000234

Cited by 1 publication

(1 citation statement)

References 32 publications

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“…Однако, несмотря на огромное количество исследований в этой области, выявлено лишь несколько значимых предикторов [1]. Важность определения предикторов и построения прогноза исхода связана с необходимостью выбора терапевтических стратегий, взаимодействия с пациентами, информирования родственников, научного исследования шизофрении и терапии данного расстройства [2]. Предикторы терапевтического ответа при шизофрении, представленные в литературе, включают случаи шизофрении в семейной истории, мужской пол, раннее начало процесса, число обострений, длительность нелеченого психоза, наличие коморбидных расстройств.…”

Section: м в ассанович гродненский государственный медицинский университет гродно беларусьunclassified

Predictors of Therapeutic Response and Length of Hospitalization in Patients With Schizophrenia During Pharmacotherapy

Assanovich¹

2021

Journal GrSMU

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Topicality. Search for scientifically based criteria for symptomatic remission and outcomes in schizophrenia is an urgent problem in modern psychiatry. Aim. To determine predictors of therapeutic response and duration of hospitalization during the course of psychopharmacotherapy in patients with schizophrenia. Material and methods. Clinical and metric examination using scales for assessing severity of positive (SAPS, PSYRATS, BABS) and negative (SANS, NSA-5) symptoms was performed in 157 patients with a diagnosis of schizophrenia twice: on admission to hospital and after the course of psychopharmacotherapy. The model for predicting therapeutic response was built using logistic regression, the model for predicting duration of hospitalization was built using linear regression using metrically justified criteria for achieving a significantly low level of severity of positive and negative symptoms as criteria for a significant therapeutic response. Results. The predictors were determined that increase and decrease likelihood of therapeutic response for scales for assessing positive and negative symptoms in patients with schizophrenia during the course of psychopharmacotherapy. Conclusions. Therapeutic response prediction models for scales for assessing the severity of positive symptoms and scales for the severity of negative symptoms are of good quality and high diagnostic value.

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Section: м в ассанович гродненский государственный медицинский университет гродно беларусьunclassified

Predictors of Therapeutic Response and Length of Hospitalization in Patients With Schizophrenia During Pharmacotherapy

Assanovich¹

2021

Journal GrSMU

View full text Add to dashboard Cite

show abstract

Using data from schizophrenia outcome study to estimate the time to treatment outcome and the early-response cut-off score that predicts outcome at week 16

Cited by 1 publication

References 32 publications

Predictors of Therapeutic Response and Length of Hospitalization in Patients With Schizophrenia During Pharmacotherapy

Predictors of Therapeutic Response and Length of Hospitalization in Patients With Schizophrenia During Pharmacotherapy

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