Introduction: Musical Performance Anxiety (MPA) is considered a condition characterized by persistent and intense apprehension in circumstances involving public musical presentation, disproportionate to the musician's aptitude level, training and preparation. The symptoms occur on a continuous severity scale that affects, at its extreme, the musical aptitude due to symptoms at the physical, behavioral and cognitive levels, as well as interfering with cognitive processing and social cognition, especially in the facial emotion recognition (FER) ability. Thus, interventions that can effectively correct these deviances are necessary. Therefore, the aims of the studies that compose this thesis are: a) to analyze the (FER) in musicians with different levels of MPA; b) to carry out a systematic review of the literature in order to present evidence about the effects of anxiolytic substances on FER in healthy individuals; c) to conduct a randomized, double-blind, placebo-controlled, cross-over clinical trial to test the OT effect on musicians with high/low MPA level in FER, mood/anxiety indicators and negative cognition. Methods: To achieve the first aim of this study, a cross-sectional, observational study was conducted with 150 musicians of both sexes, of different musical styles, who performed a FER task, after being classified according to the MPA levels. As for the second aim, a systematic literature review was carried out in accordance with the PRISMA guidelines and the Cochrane Handbook for Systematic Reviews of Interventions. Finally, for the third aim, 43 male musicians of different musical styles have participated in a randomized, placebo-controlled, cross-over clinical trial in which the 24UI of intranasal OT efficiency was tested. Results: The results showed that musicians with high levels of MPA present a global impairment in FER, expressed mainly by the difficulty in the appropriate recognition of the emotion of joy, which is associated with signs of social approval. The review of the literature showed that few substances have been tested so far, and that the changes in FER were specific and dependent on the substance mechanism of action in the central nervous system, dose and form of administration. The clinical trial presented an improvement in the recognition of the emotion of joy, only in musicians with high levels of MPA, after the OT acute use. Conclusion: The FER was specifically altered in musicians with high levels of MPA, which can be corrected with the use of intranasal OT, which appears as a promising substance for clinical use.