Condroradionecrose de laringe após radioterapia

Melo, Giulianno Molina de; Souza, Paula Demétrio de; Filho, Luiz Castro Bastos; Neves, Murilo Catafesta das; Santo, Kleber Simões do Espiríto; Cervantes, Onivaldo; Abrahão, Márcio

doi:10.1590/0100-69912017004012

Cited by 4 publications

(2 citation statements)

References 42 publications

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“…The reported prevalence of clinical LCRN ranges from 1.1% to 12.2% (Table 1). 7–13 In general, prevalence rates vary between studies, and this may be attributed to a lack of robust diagnostic principles, uncertainty in recognising signs and symptoms, or misdiagnosed tumour recurrence. Considering the latter, Gilbert et al (1988) found a startling rate of 24.4% ( n = 10/41) of ORN or chondroradionecrosis when performing histopathological analysis of 41 larynx specimens following laryngectomy for recurrent or residual carcinoma with the neoplastic process likely contributing to the elevated figures 14 .…”

Section: Discussionmentioning

confidence: 99%

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Management of laryngeal chondroradionecrosis with pentoxifylline and vitamin E: A case report and review of the literature

2021

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Laryngeal chondroradionecrosis (LCRN) is a rare complication characterised by radiation-induced fibro-atrophy and necrosis of the laryngeal cartilage. There is a mixed consensus on treatment strategy with limited cases reported in the literature. A 60-year-old female patient with a history of a poorly differentiated T3N0M0 glottic laryngeal squamous cell carcinoma treated via chemo-radiotherapy presented 18 months following treatment with discomfort of her throat and difficulty swallowing. Imaging showed fracture of the right lamina of the thyroid cartilage with accompanying soft tissue swelling representative of LCRN. A combination of pentoxifylline and tocopherol (vitamin E) (PENTO) was prescribed on the principle of managing radiation induced fibrosis. At the 1-month review, the patient's throat pain had resolved and her swallowing had improved. A further 2 months later a nasoendoscopy showed no evidence of LCRN. The PENTO protocol has been a successful management strategy in this case in the medium term.

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Section: Discussionmentioning

confidence: 99%

“…Antibiotics and steroids are often the medical regime of choice; however, there is little evidence to support their use. A total of 74 cases of LCRN have been identified in the literature and are summarised in Table 3 6,9,12,13,15,16,18,22–35 . Of the 74 patients, four were initially managed by total laryngectomy.…”

Section: Discussionmentioning

confidence: 99%

Management of laryngeal chondroradionecrosis with pentoxifylline and vitamin E: A case report and review of the literature

2021

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Outcomes of carotid sparing intensity‐modulated radiotherapy for early stage glottic cancer in 201 patients: Multicenter study of Turkish Radiation Oncology Society/TROD‐01‐007

et al. 2022

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Background: To assess and report clinical outcomes after carotid sparing intensity-modulated radiotherapy for early stage laryngeal cancer. Methods:We retrospectively analyzed 201 patients with early stage glottic laryngeal cancer treated with carotid sparing intensity-modulated radiotherapy (IMRT)/volumetric modulated arc therapy (VMAT) techniques in six TROD centers. Results: After a median follow-up of 31 months the actuarial 1-and 3-year local and locoregional control rates were 99.4% and 94.7%, 98.4% and 93%, respectively. T classification, anterior commissure involvement, IMRT technique, and type of fractionation were not found to be prognostic for local control. Overall, eight patients had lost their organ function due to recurrence or toxicity. Grade 3 and 4 acute laryngeal edema was seen in eight (4%) and one (0.5%) of patients, respectively. Grade 3 and 4 late laryngeal edema developed in two (1%) and one patient (0.5%), respectively. Conclusion:Oncologic outcomes of patients treated with carotid sparing IMRT were excellent; comparable with historical series, with acceptable side effects. Longer follow-up is needed to estimate long term effect on stroke.

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Early side effects of radiation treatment for head and neck cancer

Brook

2021

Cancer/Radiothérapie

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Condroradionecrose de laringe após radioterapia

Cited by 4 publications

References 42 publications

Management of laryngeal chondroradionecrosis with pentoxifylline and vitamin E: A case report and review of the literature

Management of laryngeal chondroradionecrosis with pentoxifylline and vitamin E: A case report and review of the literature

Outcomes of carotid sparing intensity‐modulated radiotherapy for early stage glottic cancer in 201 patients: Multicenter study of Turkish Radiation Oncology Society/TROD‐01‐007

Early side effects of radiation treatment for head and neck cancer

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