Pancreatic cancer screening

Soldan, M. Paz

doi:10.1590/0100-69912017002015

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…There was a predominance of self-declared Whites, and there is evidence in the literature of a higher prevalence of the disease in Blacks. Possible explanations for this discrepancy may relate to the predominantly mixed ethnicity in our country, as well as complex socioeconomic issues that may lead to a possible delayed access to healthcare services and postponing the diagnosis and referral for potentially curative treatment among these poorer populations (19,20) .…”

Section: Discussionmentioning

confidence: 92%

Pancreaticoduodenectomy With Venous Resection: An Analysis of 30-Day Morbidity and Mortality

Callejas

Concon

Rezende

et al. 2019

Arq. Gastroenterol.

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BACKGROUND: Pancreaticoduodenectomy (PD) with the resection of venous structures adjacent to the pancreatic head, even in cases of extensive invasion, has been practiced in recent years, but its perioperative morbidity and mortality are not completely determined. OBJECTIVE: To describe the perioperative outcomes of PD with venous resections performed at a tertiary university hospital. METHODS: A retrospective study was conducted, classified as a historical cohort, enrolling 39 individuals which underwent PD with venous resection from 2000 through 2016. Preoperative demographic, clinical and anthropometric variables were assessed and the main outcomes studied were 30-day morbidity and mortality. RESULTS: The median age was 62.5 years (IQ 54-68); 55% were male. The main etiology identified was ductal adenocarcinoma of the pancreas (82.1%). In 51.3% of cases, the portal vein was resected; in 35.9%, the superior mesenteric vein was resected and in the other 12.8%, the splenomesenteric junction. Regarding the complications, 48.7% of the patients presented some type of morbidity in 30 days. None of the variables analyzed was associated with higher morbidity. Perioperative mortality was 15.4% (six patients). The group of individuals who died within 30 days presented significantly higher values for both ASA (P=0.003) and ECOG (P=0.001) scores. CONCLUSION: PD with venous resection for advanced pancreatic neoplasms is a feasible procedure, but associated with high rates of morbidity and mortality; higher ASA e ECOG scores were significantly associated with a higher 30-day mortality.

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Section: Discussionmentioning

confidence: 92%

Pancreaticoduodenectomy With Venous Resection: An Analysis of 30-Day Morbidity and Mortality

Callejas

Concon

Rezende

et al. 2019

Arq. Gastroenterol.

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“…There is a general trend of higher incidence rates in developed countries [1]. Although not among the top 10 cancers in Brazil, it is the eighth leading cause of death from cancer, due to diagnosis in locally advanced or metastatic stage of the disease [2]. The most common and also most aggressive histological subtype of pancreatic cancer is the pancreatic ductal adenocarcinoma (PDAC), which represents 85-90% of all pancreatic neoplasms [3].…”

Section: Introductionmentioning

confidence: 99%

miR-203a-3p and MMP-2 protein are highly expressed in circulating tumor cells from patients with pancreatic carcinoma

Tarazona¹,

Abdallah²,

Flores³

et al. 2021

Preprint

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Objectives: to explore the morphological, molecular and phenotypical characteristics of circulating tumor cells (CTCs) from blood of patients with pancreatic carcinoma, and to correlate the findings with response to treatment, progression-free survival, overall survival (OS) and deep vein thrombosis (DVT). Methods: peripheral blood (10mL) was analyzed before the beginning of treatment, and after 60 and 120 days. CTCs were detected by ISET® and characterized by immunocytochemistry. For miRNAs analysis, peripheral leukocytes from the same patients and healthy individuals (controls) were collected in parallel at baseline. The expression of miRNAs was evaluated (in pool) using TaqMan™ Array Human MicroRNA Cards v2.0. Results: there were included 9 patients. The proteins MMP2 and TGFβ-RI were highly expressed (77.7%) in CTCs at baseline; at the first follow-up, MMP2 was predominant (80%) and at second follow-up, MMP2 and vimentin were predominant (50%). Circulating tumor microemboli (CTM) were found in two patients and both presented DVT. The miR-203a-3p was highly expressed in CTCs. miR-203a-3p is involved in the stimulation of epithelial-to-mesenchymal transition (EMT) and related to worse OS in pancreatic cancer (TCGA data). Conclusion: Due to the low number of patients and short follow-up, we did not observe a correlation between CTCs and response to treatment. However, there was a correlation between CTM and DVT as also miR-203a-3p was highly expressed in CTCs, corroborating the findings of EMT proteins. This study opens perspectives concerning the dynamic change in the pattern of proteins expressed along treatment and the use of miRNAs as new targets in pancreatic carcinoma.

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Clinical Effect of Driver Mutations of KRAS, CDKN2A/P16, TP53, and SMAD4 in Pancreatic Cancer: A Meta-Analysis

Jiang

et al. 2020

Genetic Testing and Molecular Biomarkers

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Pancreatic cancer screening

Cited by 7 publications

References 5 publications

Pancreaticoduodenectomy With Venous Resection: An Analysis of 30-Day Morbidity and Mortality

Pancreaticoduodenectomy With Venous Resection: An Analysis of 30-Day Morbidity and Mortality

miR-203a-3p and MMP-2 protein are highly expressed in circulating tumor cells from patients with pancreatic carcinoma

Clinical Effect of Driver Mutations of KRAS, CDKN2A/P16, TP53, and SMAD4 in Pancreatic Cancer: A Meta-Analysis

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