Clinical & Investigative Dermatologya median time to ulcer healing of 99 days with 2-layer compression therapy. In addition, more than a quarter fail to heal completely and the 12-month recurrence rate of healed venous leg ulcers may be up to 28%. Patients with longstanding, large ulcers, or who have a prior history of ulceration, are particularly resistant to healing [6].Th ere are various treatment options for venous ulcers. Th ese include conservative management, mechanical treatment, medications, and surgical options. Evidence rating a key recommendation includes compression therapy, bandages and Pentoxifylline [2]. Compression assists by reducing venous hypertension, enhancing venous return and reducing peripheral edema. However, studies show that it only has moderate eff ects on healing, with up to 50% of venous leg ulcers unhealed aft er two years of compression. Non-adherence may be the principal cause of these poor results, but presence of infl ammation in people with chronic venous insuffi ciency may be another factor, so a treatment that suppresses infl ammation and reduces the frequency of ulcer recurrence would be an invaluable intervention to complement compression treatments [7].Aspirin is a cyclooxygenase inhibitor that irreversibly reduces prostaglandin-2 and thromboxane A2, which are involved in infl ammation and platelet aggregation. It is inexpensive, widely used and readily available. Th e mechanism by which aspirin may hasten healing of VLUs is unclear but may be associated with a reduction of infl ammation, or its eff ect on the microvascular circulation, including platelet activation. In one study investigating the haemostatic eff ects of aspirin in patients with VLU, the investigators demonstrated that participants were found to have increased levels of fi brinogen and shortened coagulation rate, when compared to age-matched and sexmatched controls and that treatment with aspirin caused prolongation of the coagulation rate, which increased the rate of ulcer healing [6].Venous leg ulcers impair Quality of Life (QoL); they are open wounds, which can be large, are oft en painful, frequently become infected and leak exudate. It has signifi cant health economic burden. Th ere is, therefore, an unmet need for a more cost-eff ective and clinically eff ective treatment for VLUs.Whereas the venous leg ulcer is usually originated by external trauma, the course is oft en chronic and/or relapsing [3]. Many venous leg ulcers take over 6 months to heal; one large study demonstrated