Analysis of natural history of the diaphragmatic injury on the right in mice

Caiel, Benedito Aparecido; Scapulatempo‐Neto, Cristovam; Júnior, Arthur Soares de Souza; Júnior, Roberto Saad

doi:10.1590/0100-69912015006007

Cited by 2 publications

(2 citation statements)

References 21 publications

(25 reference statements)

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“…Contrary to studies reporting that untreated diaphragmatic injuries lead to the development of diaphragmatic hernia that causes a high rate of morbidity and mortality, experimental studies showing spontaneous healing of the injured diaphragm have also been reported. In a pig study by Shatney et al, 15 of 16 diaphragmatic injuries healed spontaneously [13], and in a study by Caiel et al using mice, right diaphragmatic injuries healed spontaneously at a rate of 57.5%, and diaphragmatic hernia did not develop [14]. In a study conducted by Perlingeiro et al with mice, it was reported that diaphragmatic injury healed spontaneously at a rate of 91.1% [15].…”

Section: Discussionmentioning

confidence: 99%

“…In a pig study by Shatney et al, 15 of 16 diaphragmatic injuries healed spontaneously [13], and in a study by Caiel et al using mice, right diaphragmatic injuries healed spontaneously at a rate of 57.5%, and diaphragmatic hernia did not develop [14]. In a study conducted by Perlingeiro et al with mice, it was reported that diaphragmatic injury healed spontaneously at a rate of 91.1% [15].…”

Section: Discussionmentioning

confidence: 99%

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Development of Diaphragmatic Hernia in Patients with Penetrating Left Thoracoabdominal Stab Wounds

2022

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Background This study aimed to investigate the consequences of repairing versus not repairing diaphragmatic injury caused by penetrating left thoracoabdominal stab wounds. Methods Diagnostic laparoscopy was performed to evaluate the left diaphragm in patients with penetrating left thoracoabdominal stab wounds who did not have an indication for emergency laparotomy. Patients who did not consent to laparoscopy were discharged without undergoing surgery. Post-discharge radiological images of patients who underwent diaphragmatic repair and radiological images of patients who could not undergo laparoscopy, both during hospitalization and after discharge, were evaluated and compared.Results Diagnostic laparoscopy was performed on 109 patients. Diaphragmatic injuries were detected and repaired in 32 (29.36%) of these patients. Seventeen patients were lost to follow-up. After a mean follow-up of 57.67 months, none of the remaining 15 patients developed a diaphragmatic hernia. On the other hand, 43 patients refused to undergo diagnostic laparoscopy. Twenty of them were lost from follow-up. The diaphragmatic injury was detected in seven of the remaining 23 patients (30.44%) during initial computed tomography (CT) examinations. In this group, the mean follow-up time was 42.57 months, and delayed diaphragmatic hernia developed in one patient (14.30%). Patients who underwent diaphragmatic repair were compared to patients who did not undergo diagnostic laparoscopy but had diaphragmatic injuries detected on their CT. No statistical differences were detected. Conclusions Diaphragmatic injuries caused by penetrating stab wounds can sometimes heal spontaneously. However, diagnostic laparoscopy is still relevant for revealing and repairing possible diaphragmatic injuries.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Development of Diaphragmatic Hernia in Patients with Penetrating Left Thoracoabdominal Stab Wounds

2022

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Análise retrospectiva de 103 casos de lesão diafragmática operados em um centro de trauma

Cardoso

Gonçalves

Machado

et al. 2017

Rev. Col. Bras. Cir.

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RESUMO Objetivo: analisar os fatores associados ao óbito em pacientes com lesão diafragmática atendidos em hospital de referência para o trauma. Métodos: estudo retrospectivo de pacientes com lesão do diafragma atendidos no Hospital Risoleta Tolentino Neves da Universidade Federal de Minas Gerais entre janeiro de 2010 e dezembro de 2014. Foi utilizado o Banco de Registros de Trauma Collector® (MD, USA). Utilizaram-se dados demográficos, localização da lesão diafragmática, lesões associadas de outros órgãos, número de lesões associadas, tipo de abordagem terapêutica, complicações e o escore de gravidade Injury Severity Score (ISS). A variável de interesse foi a ocorrência de óbito. Resultados: foram identificados 103 pacientes e a incidência de óbito foi de 16,5%. Lesões penetrantes ocorreram em 98% dos pacientes. Em análise univariada a mortalidade foi maior em pacientes cujo tratamento foi não operatório, sem rafia (p=0,023), e menor em pacientes submetidos à rafia diafragmática (p<0,001). O aumento do número de lesões associou-se ao aumento da incidência de óbitos (p=0,048). Em análise multivariada, ISS>24 (OR=4,0; p=0,029) e rafia do diafragma (OR=0,76; p<0,001) associaram-se à mortalidade. Conclusão: os achados indicam que a ruptura traumática do diafragma raramente se apresenta como lesão isolada, estando associada frequentemente à lesão de outros órgãos, especialmente fígado e vísceras ocas. Pode-se afirmar que a mortalidade foi mais elevada entre aqueles com ISS>24.

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Analysis of natural history of the diaphragmatic injury on the right in mice

Abstract: there was a predominance of healing of right hemi diaphragm, the size of initial injury didn't have influence on occurrence of the liver protection or hernia in mice.

Cited by 2 publications

References 21 publications

Development of Diaphragmatic Hernia in Patients with Penetrating Left Thoracoabdominal Stab Wounds

Development of Diaphragmatic Hernia in Patients with Penetrating Left Thoracoabdominal Stab Wounds

Análise retrospectiva de 103 casos de lesão diafragmática operados em um centro de trauma

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