Papillary neoplasias of the biliary tract

Abstract

The authors conducted a revisional study of intraepithelial papillary lesions of the bile ducts, characterized by being a kind of rare, intraductal growing cholangiocarcinoma. Articles published in the last 10 years were reviewed. The authors considered that the adenoma-carcinoma development is an important feature to warrant prophylactic measures through excisions. The histological type and biomolecular behavior may have relevance in the postoperative course of such lesions, which have a better prognosis when compared with other histological types.

Immunohistochemical Predictors for Intestinal and Pancreatobiliary Types of Adenocarcinoma of The Ampulla of Vater

“…[1][2][3][4][5] The intestinal-type epithelium covers the major duodenal papilla and the pancreatobiliary type lines the ampulla of Vater, the pancreatic duct, and the distal common bile duct. 6,7 Tumors of the IT, usually, originate from a precursor adenomatous lesion, following the adenoma-dysplasia-adenocarcinoma sequence. 8,9 Tumors of the PBT seem to be associated more frequently with neoplastic intraepithelial ductal precursor lesions, but they can also be developed from polypoid lesions with pancreatobiliary phenotypes.…”

Expression of epidermal growth factor receptor (EGFR) in cholangiocarcinomas: predictive factors and survival

“…C holangiocarcinoma (CCA) is the second most frequent primary malignant neoplasm in the liver and accounts for about 3% of all gastrointestinal cancers 1 . It originates from the epithelium of intra or extrahepatic bile ducts 2 . It has been described by Durand-Fardel for the first time in 1840, and can be divided according to its location into intrahepatic, perihilar (Klatskin tumor) and distal 3 .…”