Early trends and predictors of renal function following computed tomography-guided percutaneous cryoablation of a renal mass in patients with and without prior renal impairment

Abstract

<jats:p>Abstract Objective: To assess trends and predictors of the glomerular filtration rate (GFR) after renal mass cryoablation in patients with and without history of renal impairment. Materials and Methods: This was a retrospective study of 39 patients who underwent computed tomography-guided percutaneous cryoablation of a renal mass, divided into two groups: those with prior renal impairment (PRI+); and those without prior renal impairment (PRI−). The GFR trend and the chronic kidney disease stage were evaluated at baseline, as well as at 1, 6, and 12 months after cryoablation. Predictors of GFR at 1 and 6 months were modeled with linear regression. Results: In both groups, the mean GFR at 1 month and 6 months was significantly lower than at baseline (p &lt; 0.001 and p = 0.01, respectively). Although the GFR was lower across all time points in the PRI+ group (−26.1; p &lt; 0.001), the overall trend was not statistically different from that observed in the PRI− group (p = 0.89). Univariate analysis showed that the decline in GFR at 1 and 6 months correlated with the baseline GFR (0.77 and 0.63; p &lt; 0.001 and p = 0.03, respectively) and with the size of the ablation zone (−7.6 and −12.84, respectively; p = 0.03 for both). However, in the multivariate model, baseline GFR was predictive only of GFR at 1 month (p &lt; 0.001). Conclusion: The trend in GFR decline after cryoablation is similar for patients with and without a history of renal impairment. Baseline GFR predicts the mean GFR in the early post-cryoablation period.</jats:p>

Renal function after percutaneous cryoablation of renal masses

“…Given the ongoing technological advances in the area of diagnostic imaging and in medical knowledge, we must seek to care for our patients through the use of methods that are increasingly less invasive, in order to obtain the best possible result and with the fewest possible complications. In view of that, we believe that the work conducted by Staziaki et al (9) makes a noteworthy contribution.…”

“…The current issue of Radiologia Brasileira features an interesting article by Staziaki et al (9) entitled "Early trends and predictors of renal function following computed tomographyguided percutaneous cryoablation of a renal mass in patients with and without prior renal impairment". In that retrospective study, 39 patients underwent renal mass cryoablation.…”

Percutaneous treatment of renal tumours

“…8 Even in patients with pre-procedure renal impairment, another study of 39 patients who underwent cryoablation, showed that there was an initial decline of renal function immediately after ablation which recovered over time with overall no change in chronic kidney disease (CKD) stage. 16…”

“…In a 2014 study of 200 RFA ablations in 165 patients with a mean tumour size of 2.9 cm, 161 of 165 (98%) patients had preservation of renal function 8 . Even in patients with pre‐procedure renal impairment, another study of 39 patients who underwent cryoablation, showed that there was an initial decline of renal function immediately after ablation which recovered over time with overall no change in chronic kidney disease (CKD) stage 16 …”