Poorly differentiated large-cell neuroendocrine carcinoma of the paranasal sinus

Campos, Helder Groenwold; Altemani, Albina; Altemani, João Maurício Carrasco; Soares, Davi Ferreira; Reis, Fabiano

doi:10.1590/0100-3984.2016.0184

Cited by 3 publications

(2 citation statements)

References 12 publications

(11 reference statements)

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“…Interestingly, the LCNECs in Campos’s and Zhao’s reports achieved complete remission with chemoradiation therapy without surgical resection, although the tumor sizes were relatively large. 19 , 20) However, the LCNECs in both cases did not extend into the intracranial fossa. Sensitivity to chemoradiation therapy may be different according to tumor size, extension, complications, and molecular findings.…”

Section: Discussionmentioning

confidence: 83%

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Large Cell Neuroendocrine Carcinoma in the Sinonasal Cavity with Large Intracranial Extension Treated with Endonasal Endoscopic and Transcranial Combined Surgery: A Case Report

Rai

Nishioka

Hara

2021

NMC Case Report Journal

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Large cell neuroendocrine carcinoma (LCNEC) is a rare malignant tumor that typically arises in the lungs. It is especially rare in the sinonasal cavity, and treatment has not been established. In this study, we present the case of a 56-year-old woman with a large sinonasal LCNEC that extended into her brain. We performed endonasal endoscopic and transcranial combined surgery followed by chemoradiation therapy. The combined surgery enabled us to approach and remove the extensive tumor from two different directions at one time less invasively. We have achieved good tumor control for 18 months so far.

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Section: Discussionmentioning

confidence: 83%

“…Including our case, 12 sinonasal LCNECs have been reported (Table 1). 4,[15][16][17][18][19][20] Eight cases were resected surgically. The endoscopic approach was used in two cases (Lahma et al 18) and our case), and the combined endoscopic and transcranial approaches were used only in our case according to our review of published papers.…”

Section: Discussionmentioning

confidence: 99%

Large Cell Neuroendocrine Carcinoma in the Sinonasal Cavity with Large Intracranial Extension Treated with Endonasal Endoscopic and Transcranial Combined Surgery: A Case Report

Rai

Nishioka

Hara

2021

NMC Case Report Journal

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Poorly differentiated orbital neuroendocrine carcinoma

Zhang,

Jiro,

Pekmezci

et al. 2023

BMJ Case Rep

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A man in his 70s presented with painless bilateral eyelid oedema and vertical diplopia. Evaluation showed a restrictive pattern of extraocular motility testing with MRI demonstrating significant enlargement of the right superior rectus and left superior oblique muscles along with right orbital fat stranding. Subsequent right orbital biopsy revealed poorly differentiated high-grade neuroendocrine carcinoma without a systemic primary site on further diagnostic workup. The patient was treated with carboplatin and etoposide and passed away from an infection a month after diagnosis. This case along with a review of other published cases highlights the varied presentation of orbital neuroendocrine carcinomas that may mimic a broad differential of orbital processes, thus requiring careful diagnostic workup. Subsequently, additional considerations in metastatic evaluation should be based on tumour histological features.

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Preoperative computed tomography evaluation of the paranasal sinuses: what should the physician know? - pictorial essay

2019

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The introduction of functional endoscopic sinus surgery in the 1980s brought about a drastic change in the treatment of patients with rhinosinusitis, improving quality of life through the removal of pathological processes or anatomical variations that obstruct the drainage pathways of the paranasal sinuses. However, despite the routine use of computed tomography in the anatomical evaluation of the paranasal sinuses, most radiological reports still do not provide sufficient information to guide the surgical planning. The objective of this pictorial essay was to demonstrate, through computed tomography, the main anatomical variations of the paranasal sinuses, the recognition of which is fundamental for preoperative planning, in order to avoid treatment failure and iatrogenic complications.

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Poorly differentiated large-cell neuroendocrine carcinoma of the paranasal sinus

Cited by 3 publications

References 12 publications

Large Cell Neuroendocrine Carcinoma in the Sinonasal Cavity with Large Intracranial Extension Treated with Endonasal Endoscopic and Transcranial Combined Surgery: A Case Report

Large Cell Neuroendocrine Carcinoma in the Sinonasal Cavity with Large Intracranial Extension Treated with Endonasal Endoscopic and Transcranial Combined Surgery: A Case Report

Poorly differentiated orbital neuroendocrine carcinoma

Preoperative computed tomography evaluation of the paranasal sinuses: what should the physician know? - pictorial essay

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