Impact of the integration of proton magnetic resonance imaging spectroscopy to PI-RADS 2 for prediction of high grade and high stage prostate cancer

Leapman, Michael; Wang, Zhen J.; Behr, Spencer C.; Kurhanewicz, John; Zagoria, Ronald J.; Carroll, Peter R.; Westphalen, Antonio C.

doi:10.1590/0100-3984.2016.0117

Cited by 10 publications

(2 citation statements)

References 29 publications

(32 reference statements)

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“…PI-RADS v2 does not include MRSI at all. However, it is still recognised as a useful addition for centres with the expertise to perform the study (Leapman et al 2017).…”

Section: Tumour Detection Volume Estimation Grading and Stagingmentioning

confidence: 99%

Clinical applications ofin vivomagnetic resonance spectroscopy in oncology

Payne

2018

Phys. Med. Biol.

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Brief introduction to magnetic resonance spectroscopyMagnetic resonance spectroscopy (MRS) can be used to probe tissue biochemistry in vivo by detecting signals from many metabolites, primarily those which have a low molecular weight and a concentration of a few mmol l −1 . MRS uses the same hardware as magnetic resonance imaging (MRI). Examples of 1 H MR spectra acquired from brain are shown in figure 1. A brief introduction is given here for the benefit of readers not familiar with the basic principles of MRS to provide a basic framework to understand the subsequent clinical applications. For more detail there are a number of good books describing in vivo MRS with helpful chapters on methods and applications (de Graaf 2007, Barker et al 2010.Some atoms (such as 1 H, 13 C, 31 P, 23 Na and 19 F) have nuclei with a magnetic dipole moment. The sum effect of all the magnetic dipoles is known as the bulk magnetisation. In a magnetic field and at thermal equilibrium the bulk magnetisation is aligned with the magnetic field. Application of an alternating magnetic field at the appropriate frequency (see equation (1) below) causes the bulk magnetisation to rotate away from the direction of the static magnetic field. The magnetisation then freely rotates about the static field at this same frequency. In time the bulk magnetisation relaxes back to thermal equilibrium parallel to the static field. If a detector coil is placed close to the sample a small current will be induced in it by the rotating magnetisation. This signal is known as the free induction decay (FID). The spectrum of frequency components (such as shown in figure 1) is obtained by Fourier transform of this signal.The frequency position of a resonance peak in Hz (often known as the Larmor precession frequency) is determined by the following equation:where γ is the gyromagnetic ratio of the nucleus (e.g. 2.675 × 10 8 rad/T/s for 1 H), and B local is the local field at the atomic nucleus. B local is determined primarily by the magnitude of the applied magnetic field (typically 1.5 T or 3 T for clinical MRI scanners), but it is slightly modified by the shielding effect of the electron cloud associated with bonding electrons (the chemical shift

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“…PI-RADS v2 does not include MRSI at all. However, it is still recognised as a useful addition for centres with the expertise to perform the study (Leapman et al 2017).…”

Section: Tumour Detection Volume Estimation Grading and Stagingmentioning

confidence: 99%

Clinical applications ofin vivomagnetic resonance spectroscopy in oncology

Payne

2018

Phys. Med. Biol.

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“…Furthermore, there is potential to stint contrast medium containing gadolinium. However further research documented the possible use of further MRI sequences, especially in the diagnosis of early staged prostate cancer[25] [26] [27]. Kim et al recommended the use of multiparametric MRI in case of PI-RADS score 3 [28].…”

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confidence: 99%

Evaluation of Multiparametric MRI of the Prostate: Impact of Standardized Examination Protocols and the Endorectal Coil

Rampoldt¹,

Huebner²,

Zangos³

et al. 2020

OJMI

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Purpose: The aim of the present study was to evaluate the patient population, different MRI examination protocols and the patient's acceptance of the endorectal coil in the diagnosis of prostate cancer regarding the current discussion in PI-RADS v2.1. Material and Methods: In our institute, 256 patients were examined with different protocols and separated into six groups. The value of the different MRI protocols was identified by analyzing sensitivity, specificity, negative predictive value and positive predictive value. The patient population was tested for statistically significant differences in their characteristics to detect a distortion of the results. The patients' acceptance of endorectal coil was evaluated by a query. Results: In total 4.7% of the patients would not recommend a MRI examination because of subjective physical strain and 65.6% of all patients subjectively saw a benefit in the examination in regard to an optimal diagnostic process. The protocol groups reached a sensitivity from 66.7%-100%, a specificity from 40%-75%, a positive predictive value from 33.3%-80% and a negative predictive value from 66.7%-100%. Conclusion: MRI of the prostate is a safe and comfortable tool with high sensitivity and negative predictive value and the potential of ruling out a clinically significant prostate cancer. However, a general recommendation for the use of biparametric MRI could not be given, considering a higher sensitivity could be performed when using dynamic contrast-enhanced MRI or spectroscopy.

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Lost in translation: lessons learned from the “demise” of MRSI of the prostate

Westphalen

2019

Abdom Radiol

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Impact of the integration of proton magnetic resonance imaging spectroscopy to PI-RADS 2 for prediction of high grade and high stage prostate cancer

Cited by 10 publications

References 29 publications

Clinical applications ofin vivomagnetic resonance spectroscopy in oncology

Clinical applications ofin vivomagnetic resonance spectroscopy in oncology

Evaluation of Multiparametric MRI of the Prostate: Impact of Standardized Examination Protocols and the Endorectal Coil

Lost in translation: lessons learned from the “demise” of MRSI of the prostate

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