Chordoid glioma of the third ventricle

Destefani, Marília Henrique; Mello, Alessandro Spano; Oliveira, Ricardo Santos de; Simão, Gustavo Novelino

doi:10.1590/0100-3984.2014.0125

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…When epithelioid‐like cells were predominant, T1WI showed slight hypointensity, T2WI was predominantly iso‐ and hypointensity, with patches and strips of slight hyperintensity interspersed within, and FLAIR showed slight hyperintensity. Nine cases (69.2%) displayed FLAIR hyperintensity in our study, and it was also reported in another research, 15 which can be taken as one of the characteristic manifestations of CG. When the mucus stroma is predominant, T1WI showed hypointensity, and T2WI shows significant hyperintensity.…”

Section: Discussionsupporting

confidence: 89%

Assessment of magnetic resonance imaging and histopathological changes in chordoid glioma: A retrospective analysis of 13 cases

Huang,

Deng,

Wen

et al. 2024

Int J Imaging Syst Tech

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Chordoid glioma (CG) is a rare tumor, and its predominantly anterior location is in the third ventricle. However, the clinical characteristics of CG were not obvious, and there was less knowledge of CG‐related imaging. This study aimed at exploring the MRI imaging features of CG. We retrospectively analyzed the MRI data of 13 patients diagnosed with CG from January 2015 to May 2021. The pathological change of tumor tissue was observed using H&E staining and immunohistochemical. The MRI manifestations of CG often include phyllode masses in the anterior part of the third ventricle. T2WI is dominated by iso‐ and hypointensity, with internal patchy hyperintensity, marked enhancement, and peritumoral edema. The “eight‐character edema sign” runs along the optic beam and may be useful for distinguishing CG from other tumors. CG has unique MRI manifestations that can serve as a diagnostic basis. Our study may help to enhance the understanding of imaging about CG and improve the diagnosis of patients with CG.

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Section: Discussionsupporting

confidence: 89%

Assessment of magnetic resonance imaging and histopathological changes in chordoid glioma: A retrospective analysis of 13 cases

Huang,

Deng,

Wen

et al. 2024

Int J Imaging Syst Tech

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“…Of note, this patient had symptoms for 4 years prior to surgical treatment, which is long for this disease and might suggest advanced disease at the time of initial diagnosis [11]. Other fatal cases have been reported, but death has typically been associated with post-operative complications rather than tumor progression [12]. No other cases with comparable rapid tumor progression causing death have been reported (Table 3).…”

Section: Discussionmentioning

confidence: 87%

Chordoid glioma of the third ventricle: report of a rapidly progressive case

et al. 2017

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Chordoid gliomas are slowly growing third ventricular tumors that can be challenging to manage clinically. Rapid progression causing death has not been previously reported for this tumor type. We present and discuss a case of chordoid glioma that arose in a 46-year-old female who presented with progressive fatigue, headache, and altered mental status, attributable to severe hydrocephalus caused by a third ventricular mass. She underwent urgent subtotal resection and ventriculo-peritoneal shunt placements. Post-operative MRI noted residual tumor in the anterior resection cavity. An MRI performed 9 weeks later showed substantial progression, with marked tumor enlargement and compression of adjacent hypothalamic structures and the optic chiasm. Despite a course of radiation therapy, the tumor continued to enlarge, and the patient died from tumor progression 7 months after initial presentation. Post-mortem exam demonstrated a mass that expanded the third ventricle and compressed adjacent hypothalamic, thalamic and suprasellar structures. Histologic and immunohistochemical studies confirmed a chordoid glioma and revealed multifocal coagulative necrosis and intravascular thrombosis, which are unusual in this tumor type. Cytogenomic microarray testing revealed numerous DNA copy number abnormalities, many of which had not previously been reported in this tumor. The pathologic and cytogenetic changes may correlate with the aggressive behavior of this chordoid glioma and can be pursued by future investigation of additional cases.

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“…The expansive lesions of the central nervous system alone are not diagnostic of TSC and may be seen in other pathological conditions ( 6 - 10 ) .…”

Section: Intracranial Manifestationsmentioning

confidence: 99%

Imaging of tuberous sclerosis complex: a pictorial review

et al. 2017

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Tuberous sclerosis complex (TSC) is a genetically determined hamartomatous neurocutaneous disease with high phenotypic variability. TSC is characterized by widespread hamartomas and benign, or rarely malignant, neoplasms distributed in several organs throughout the body, especially in the brain, skin, retina, kidney, heart, and lung. Common manifestations include cortical tubers, subependymal nodules, white matter abnormalities, retinal abnormalities, cardiac rhabdomyoma, lymphangioleiomyomatosis, renal angiomyolipoma, and skin lesions. The wide range of organs affected by the disease implies that TSC1 and TSC2 genes play important roles in the regulation of cell proliferation and differentiation. Although recent advances in treatment have improved morbidity, the prognosis remains quite poor and nearly 40% of patients die by the age of 35 years. Imaging is important in the evaluation of TSC because of its role not only in presumptive diagnosis, but also in defining the full extent of involvement. This information allows a better understanding of the behavioural phenotype, as related to lesion location. Imaging also contributes to treatment planning. This pictorial review describes common and uncommon imaging manifestations of TSC.

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Chordoid glioma of the third ventricle

Cited by 6 publications

References 7 publications

Assessment of magnetic resonance imaging and histopathological changes in chordoid glioma: A retrospective analysis of 13 cases

Assessment of magnetic resonance imaging and histopathological changes in chordoid glioma: A retrospective analysis of 13 cases

Chordoid glioma of the third ventricle: report of a rapidly progressive case

Imaging of tuberous sclerosis complex: a pictorial review

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