Tracheobronchopathia osteochondroplastica: computed tomography, bronchoscopy and histopathological findings

Ribeiro, G; Natal, Marcelo Ricardo Canuto; Silva, Eduardo Felipe; Freitas, Sabrina Cardoso; Moraes, Waldete Cabral; Maciel, Fernanda Cunha

doi:10.1590/0100-3984.2014.0056

Cited by 8 publications

(5 citation statements)

References 10 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, symptomatic patients may present with a long-standing history of an unresolved non-productive cough, change in voice and/or breathing difficulty 11–13. Cough is the most common complaint, seen in 66% of the symptomatic patients 14. Due to non-specific and inexplicit symptoms, TO may mimic laryngeal amyloidosis or sarcoidosis clinically.…”

Section: Discussionmentioning

confidence: 99%

Tracheobronchopathia osteochondroplastica: awareness is the key for diagnosis and management

Devaraja¹,

Sagar

Chirom

2017

BMJ Case Reports

View full text Add to dashboard Cite

Tracheobronchopathia osteochondroplastica is a rare airway disease of unknown aetiology. Due to overlapping symptomology and lack of awareness, the condition is often missed resulting in unnecessary medical or surgical treatment. A male patient presented with a long-standing history of hoarseness and had earlier received treatment for bronchial asthma and tuberculosis. On evaluation, he had typical submucosal calcified nodules distributed throughout the trachea sparing the posterior membranous part. Although the biopsy confirmed the diagnosis of tracheobronchopathia osteochondroplastica in our case, histopathological examination is not always needed to make this diagnosis. Our patient has been kept under conservative management and is having non-progression of disease at 1-year follow-up. After having reviewed the literature related to pathophysiology and management of tracheobronchopathia osteochondroplastica, we emphasise on the fact that the treating physicians' awareness about this condition is the key to its diagnosis and management.

show abstract

Section: Discussionmentioning

confidence: 99%

Tracheobronchopathia osteochondroplastica: awareness is the key for diagnosis and management

Devaraja¹,

Sagar

Chirom

2017

BMJ Case Reports

View full text Add to dashboard Cite

show abstract

“…Non-infectious inflammatory thickening of the trachea and central bronchi may occur in granulomatosis with polyangiitis (GPA), relapsing polychondritis and sarcoidosis [12]. The main radiographic findings of granulomatosis with polyangiitis with involvement of the large airways are circumferential mucosal thickening, irregularity, and ulceration.…”

Section: Discussionmentioning

confidence: 99%

A case of tracheobronchial amyloidosis with emphasis on differential diagnosis

et al. 2023

View full text Add to dashboard Cite

Tracheobronchial amyloidosis is a manifestation of amyloidosis of the respiratory tract characterized by focal or diffuse deposition of amyloid in the submucosa of the trachea and proximal bronchi. Tracheobronchial amyloidosis is not associated with systemic amyloidosis or pulmonary parenchymal involvement. It affects predominantly men aged over fifty. Depending on the part of the tracheobronchial tree that is affected, stenosis of the airways causes a variety of unspecific symptoms. Diagnosis is reached by means of typical presentation in CT scan followed by bronchoscopy and histopathological confirmation. Tracheobronchial amyloidosis should be borne in mind in the differential diagnosis of patients with chronic cough and/or dyspnea or recurrent respiratory infections.

show abstract

“…TBPO is definitively diagnosed by bronchoscopy during which the endobronchial nodules are biopsied and sent for histopathological analysis. Patients who experience symptoms might undergo imaging in the form of a chest CT scan prior to an invasive procedure [6]. Bronchoscopy, however, is most definitive diagnostic tool.…”

Section: Discussionmentioning

confidence: 99%

“…The severity of symptoms depends on the location and spectrum of obstruction of the airways. These diagnostic modalities may also be supplemented by spirometry and pulmonary function tests [6].…”

Section: Discussionmentioning

confidence: 99%

Rare Manifestation of Idiopathic Tracheobronchopathia Osteochondroplastica: Misdiagnosed and Untreated Entity?

Rana¹,

Mezughi²,

Malik³

et al. 2020

Cureus

View full text Add to dashboard Cite

Tracheobronchopathia osteochondroplastica (TBPO) is a rare benign disease of unknown cause, in which multiple cartilaginous or bony submucosal nodules project into the trachea and proximal bronchi. It usually occurs in men in their fifth decade and can cause airway obstruction, bleeding and chronic cough; patients are more prone to postobstructive pneumonia and chronic lung infection in some instances. We report a case of a 69year-old female who presented with shortness of breath and lower extremity swelling over the past couple of weeks. Echocardiography (ECHO) was consistent with heart failure with preserved ejection fraction, and she was treated with diuretics accordingly. Imaging revealed persistent pleural effusions bilaterally, more pronounced on the right side. During the course of her hospitalization, the patient coded once and had to be resuscitated. She had bronchoscopy done and pathology was consistent with TBPO. In this condition, there are numerous osseous or cartilaginous submucosal nodules in the trachea and the main bronchus and nodules are formed due to the deposition of calcium phosphate that results in the proliferation of osseous and cartilaginous structures resulting in the obstruction of large airways. Treatment for the most part is supportive and resolves around bronchodilators for symptomatic relief.

show abstract

Tracheobronchopathia osteochondroplastica: computed tomography, bronchoscopy and histopathological findings

Cited by 8 publications

References 10 publications

Tracheobronchopathia osteochondroplastica: awareness is the key for diagnosis and management

Tracheobronchopathia osteochondroplastica: awareness is the key for diagnosis and management

A case of tracheobronchial amyloidosis with emphasis on differential diagnosis

Rare Manifestation of Idiopathic Tracheobronchopathia Osteochondroplastica: Misdiagnosed and Untreated Entity?

Contact Info

Product

Resources

About