Molecular identification of Sporothrix species involved in the first familial outbreak of sporotrichosis in the state of Espírito Santo, southeastern Brazil

Oliveira, Manoel Marques Evangelista; Maifrede, Simone Bravim; Ribeiro, Maria Aparecida; Zancopé‐Oliveira, Rosely Maria

doi:10.1590/0074-0276130239

Cited by 19 publications

(15 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This information would be important in view of the emerging changes in the epidemiological profile of the disease in the last decades in Brazil. 11,[14][15][16] However, although we have reported few autochthonous cases of zoonotic sporotrichosis caused by S. brasiliensis, related to contact with cats in the state of Espírito Santo (some of which were included in this study), 20,21 our results suggest the occurrence of the "classic disease transmission pattern," probably caused by S. schenckii s.s. 22 between 1982 and 2012.…”

Section: Discussionmentioning

confidence: 85%

“…Some of these cases were partially described in previous publications. [20][21][22][23] The majority of the patients were male (80.7%, 4:1 male-to-female ratio); most patients were Caucasian (86.5%), and showed an age range from 6 to 77 years. Only six patients (3.5%) were younger than 12 years old ( Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…[14][15][16] In the local context, the largest sporotrichosis case series have been reported in Southern and Southeastern Brazil, the main endemic areas of the disease. [17][18][19] There is little sporotrichosis-related information in the state of Espírito Santo, [20][21][22][23] also located within southeastern Brazil. In this way, our findings could be used in the state health surveillance program, for understanding and comparing the actual disease epidemiological changing pattern in the country.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

Caus

Zanotti

Faccini-Martínez

et al. 2019

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

This study discusses a historical patient series and is designed to describe clinical and epidemiological characteristics of human sporotrichosis in the state of Espírito Santo, Brazil. Data were derived from patients treated at the Infectious Diseases service of Cassiano Antônio Moraes University Hospital in Vitória, the state capital, from July 1982 to June 2012. A total of 171 patients were diagnosed with sporotrichosis, mostly men (80.7%) with a median age of 33 years and 5 months. We can presume an approximate average incidence rate of 4.9 cases per 100,000 inhabitants during the studied period. All the patients were involved in occupational or leisure activities with direct contact with soil or plants. Most cases were recorded in the mountainous region of the state during the hot and rainy periods. The average time elapsed from lesion progression to diagnosis was 3 months, with the lymphocutaneous form being the most common (70.2%), followed by the fixed cutaneous form (28.6%). Diagnosis was confirmed in 93.6% of the cases by culturing Sporothrix spp. in Sabouraud dextrose agar, and from the clinical features in the remaining cases. Aspiration of cutaneous nodule secretions was the best method for the collection of clinical specimens for disease diagnosis. A 25% saturated solution of potassium iodide (SSKI) was provided to almost all patients (98.8%), with therapeutic success. In conclusion, in this retrospective study in the state of Espírito Santo, we found that sporotrichosis affects primarily the ³ 10-year-old population, and the most common presentation is the lymphocutaneous form affecting the lower and upper limbs, and the infection appeared to be acquired predominantly through occupational activities. Treatment with SSKI was safe and effective.

show abstract

Section: Discussionmentioning

confidence: 85%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

Caus

Zanotti

Faccini-Martínez

et al. 2019

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…19 S. brasiliensis, the most virulent species of the complex, 4 has frequently been reported in infections in Brazil, often affecting immunocompetent patients. Case reports of lung injury in HIV negative patients, 28 a familial outbreak in the southeastern of Brazil, 27 and even resistance to itraconazole treatment in animals have been reported. 12 Sporothrix species are also the most frequent pathogens in cases of osteoarticular infection in immunocompetent patients.…”

Section: Resultsmentioning

confidence: 99%

Interference of melanin in the susceptibility profile of Sporothrix species to amphotericin B

Mario

Santos

Denardi

et al. 2016

Revista Iberoamericana de Micología

View full text Add to dashboard Cite

“…In all cases, cats seemed to play an important role in the transmission of the disease: patients had contact with cats with sporotrichosis and more than one family member presented lesions simultaneously. Specifically, Ss368, Ss382 and Ss383 (cat) corresponded to well‐documented cases of zoonosis . The patient (Ss380) was a woman, originally from Rio de Janeiro.…”

Section: Discussionmentioning

confidence: 99%

Human sporotrichosis beyond the epidemic front reveals classical transmission types in Espírito Santo, Brazil

Araújo

Rodrigues

Fernandes

et al. 2015

Mycoses

View full text Add to dashboard Cite

Sporotrichosis has emerged as the main subcutaneous mycosis of humans and animals around the world. With particular differences in frequency, the major species includes Sporothrix brasiliensis, S. schenckii, S. globosa and S. luriei. In Brazil, the main aspect of this epidemic is based on the zoonotic transmission through the scratches and bites of diseased cats contaminated with S. brasiliensis. Areas free of feline sporotrichosis are poorly characterised in Brazil. We investigated by molecular tools the epidemiology of human sporotrichosis in the Espírito Santo (ES) state, an area adjacent to Rio de Janeiro where is the epicentre of the long-lasting outbreak of cat-transmitted sporotrichosis. The human cases in the ES state reveal the prevalence of classical transmission types where subjects are mainly infected by accidental traumatic inoculation during manipulation of contaminated plant material. In agreement with an environmental source, Sporothrix schenckii was the major aetiological agent in the classical transmission. Unlike Rio de Janeiro, this study shows that cat-transmitted epidemic in Espírito Santo is still scanty, although the geographic proximity and similar climatic features. Sporothrix brasiliensis was the agent in the feline-transmitted cases. Sporothrix globosa was isolated from a patient with fixed cutaneous lesions that did not report any contact with diseased animals. In conclusion, beyond the borders of Rio de Janeiro epidemic, agents of sporotrichosis in Espírito Santo show a scattered occurrence with high species diversity.

show abstract

Molecular identification of Sporothrix species involved in the first familial outbreak of sporotrichosis in the state of Espírito Santo, southeastern Brazil

Cited by 19 publications

References 9 publications

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

Interference of melanin in the susceptibility profile of Sporothrix species to amphotericin B

Human sporotrichosis beyond the epidemic front reveals classical transmission types in Espírito Santo, Brazil

Contact Info

Product

Resources

About