JC polyomavirus infection in candidates for kidney transplantation living in the Brazilian Amazon Region

Melo, Fernando Assis Ferreira; Bezerra, Ana Caroline Fonseca; Ishak, Marluísa de Oliveira Guimarães; Ishak, Ricardo; Vallinoto, Izaura Maria Vieira Cayres; Vallinoto, Antônio Carlos Rosário

doi:10.1590/0074-0276108022013003

Cited by 3 publications

(4 citation statements)

References 30 publications

(33 reference statements)

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“…The prevalence rates of polyomavirus infection vary according to the population examined and the detection method used. In the present study, the prevalence of infection in patients with CKD was 30.2%, higher than the rates reported by Pires et al [ 29 ] and [ 30 ], who reported prevalence rates of approximately 4% in urine samples from patients with CKD in the Brazilian cities of Belém (Pará state) and Acre, respectively. In contrast, in a study conducted in the metropolitan region of Belém involving the general population, Cayres-Vallinoto et al detected the virus in 33% of the investigated samples.…”

Section: Discussioncontrasting

confidence: 80%

“…The detection of polyomaviruses in dialysis patients reinforces the idea that the pre-transplantation viral status should be considered an important risk factor for reactivation in the post-transplantation period because all recipient patients are immunosuppressed to avoid rejection of the allograft, which favors viral reactivation. In the transplanted group, the prevalence of polyomavirus was 20%, higher than that found by some authors [ 29 , 30 , 35 ] but lower than the majority described in the literature [ 20 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ].…”

Section: Discussioncontrasting

confidence: 64%

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Prevalence of JC and BK Polyomavirus Infection in Patients with Chronic Kidney Disease in the State of Pará, Brazil

et al. 2022

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The polyomaviruses that infect humans, JC virus (JCV) and BK virus (BKV), can establish persistent infections in the cells that make up the renal system, causing nephritis and BKV-associated nephropathy in up to 10% of renal transplant patients, and of these, 90% lose the graft and return for hemodialysis. This study aimed to determine the prevalence of polyomaviruses (PyV) in the population with chronic kidney disease (CKD), classified into three groups (conservative, dialysis, and transplanted) and a control group. Urine samples were collected from 290 individuals, including 202 patients with CKD and 88 from the control group. PyV screening was performed by PCR amplification of a fragment of the VP1 region, and the JCV and BKV species were distinguished through enzymatic digestion with the restriction endonuclease BamHI from the amplification of a TAg region. All amplification products were visualized on a 3% agarose gel. The prevalence of PyV infection was correlated with clinical-epidemiological variables using the chi-squared and Fisher’s exact tests. In the group with CKD, the prevalence of PyV was 30.2%, a higher rate being observed in conservative patients (36.66%; 22/60), followed by dialysis patients (30.48%; 25/82), and transplanted patients (20%; 12/60). In the control group, the prevalence was 46.59% (41/88). The differentiation between species revealed that JCV was present in 77.8% and BKV in 22.2% of the group with CKD. The prevalence of infection was higher in male patients (59.32%), whose most common pathology was systemic arterial hypertension (35.59%). In the group of transplanted patients, there was a statistically significant association between infection and the use of the immunosuppressant azathioprine (p = 0.015). The prevalence of PyV infection was higher in the control group than in the group with CKD, being predominant in males and in patients with systemic arterial hypertension.

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Section: Discussioncontrasting

confidence: 80%

Section: Discussioncontrasting

confidence: 64%

Prevalence of JC and BK Polyomavirus Infection in Patients with Chronic Kidney Disease in the State of Pará, Brazil

et al. 2022

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“…The polyomavirus infection rates may vary between different sectors of the country's population as it was reported previously [23,25,28,30]. However, in the present study no difference was found between individuals from north, center or south of Tunisia for the two studied populations.…”

Section: Discussionsupporting

confidence: 46%

BK and JC virus infections in healthy patients compared to kidney transplant recipients in Tunisia

Boukoum

Nahdi

Sahtout

et al. 2016

Microbial Pathogenesis

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“…This particular JCV presents a stable genomic structure and sequence and is referred to as the archetype [12,13]. Archetype JCV is detected in the urine of 7% to 46% of immunocompetent individuals [4,[14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Database and Statistical Analyses of Transcription Factor Binding Sites in the Non-Coding Control Region of JC Virus

Nakamichi

Shimokawa

2021

Viruses

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JC virus (JCV), as an archetype, establishes a lifelong latent or persistent infection in many healthy individuals. In immunocompromised patients, prototype JCV with variable mutations in the non-coding control region (NCCR) causes progressive multifocal leukoencephalopathy (PML), a severe demyelinating disease. This study was conducted to create a database of NCCR sequences annotated with transcription factor binding sites (TFBSs) and statistically analyze the mutational pattern of the JCV NCCR. JCV NCCRs were extracted from >1000 sequences registered in GenBank, and TFBSs within each NCCR were identified by computer simulation, followed by examination of their prevalence, multiplicity, and location by statistical analyses. In the NCCRs of the prototype JCV, the limited types of TFBSs, which are mainly present in regions D through F of archetype JCV, were significantly reduced. By contrast, modeling count data revealed that several TFBSs located in regions C and E tended to overlap in the prototype NCCRs. Based on data from the BioGPS database, genes encoding transcription factors that bind to these TFBSs were expressed not only in the brain but also in the peripheral sites. The database and NCCR patterns obtained in this study could be a suitable platform for analyzing JCV mutations and pathogenicity.

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JC polyomavirus infection in candidates for kidney transplantation living in the Brazilian Amazon Region

Cited by 3 publications

References 30 publications

Prevalence of JC and BK Polyomavirus Infection in Patients with Chronic Kidney Disease in the State of Pará, Brazil

Prevalence of JC and BK Polyomavirus Infection in Patients with Chronic Kidney Disease in the State of Pará, Brazil

BK and JC virus infections in healthy patients compared to kidney transplant recipients in Tunisia

Database and Statistical Analyses of Transcription Factor Binding Sites in the Non-Coding Control Region of JC Virus

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