Prevalence and force of Plasmodium vivax blood-stage infection and associated clinical malaria burden in the Brazilian Amazon

Monteiro, Wuelton Marcelo; Karl, Stephan; Kuehn, Andrea; Almeida, Anne Cristine Gomes de; White, Michael; Vítor-Silva, Sheila; Melo, Gisely Cardoso de; Brito-Sousa, José Diego; Baía-da-Silva, Djane Clarys; Silva-Neto, Alexandre Vilhena; Sampaio, Vanderson Souza; Bassat, Quique; Felger, Ingrid; Müeller, Ivo; Lacerda, Marcus Vinícius Guimarães

doi:10.1590/0074-02760210330

Cited by 4 publications

(3 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One study was conducted in two villages in Kanchanaburi and Ratchaburi provinces, Thailand, respectively, in May 2013 until June 2014, enrolling 999 participants (Table 1 ) [ 8 ]. The other study took place in the peri-urban part of Manaus, Brazil, from April 2013 until March 2014 with 1274 enrolled participants [ 47 ].…”

Section: Methodsmentioning

confidence: 99%

“…Spatial signatures of PCR-confirmed P. vivax and P. falciparum infections were revealed by assessing the pooled prevalence of infections around confirmed index infections in widening spatial and temporal windows. Spatial and temporal clustering of infections was demonstrated in both cross-sectional surveys and cohort studies from a diverse spectrum of study sites in Brazil [ 6 , 47 ], Thailand [ 7 , 8 ], Cambodia [ 9 ], and Solomon Islands [ 48 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The spatial signature of Plasmodium vivax and Plasmodium falciparum infections: quantifying the clustering of infections in cross-sectional surveys and cohort studies

Sandfort

Monteiro

Lacerda

et al. 2023

Malar J

Self Cite

View full text Add to dashboard Cite

Background Over the last decades, enormous successes have been achieved in reducing malaria burden globally. In Latin America, South East Asia, and the Western Pacific, many countries now pursue the goal of malaria elimination by 2030. It is widely acknowledged that Plasmodium spp. infections cluster spatially so that interventions need to be spatially informed, e.g. spatially targeted reactive case detection strategies. Here, the spatial signature method is introduced as a tool to quantify the distance around an index infection within which other infections significantly cluster. Methods Data were considered from cross-sectional surveys from Brazil, Thailand, Cambodia, and Solomon Islands, conducted between 2012 and 2018. Household locations were recorded by GPS and finger-prick blood samples from participants were tested for Plasmodium infection by PCR. Cohort studies from Brazil and Thailand with monthly sampling over a year from 2013 until 2014 were also included. The prevalence of PCR-confirmed infections was calculated at increasing distance around index infections (and growing time intervals in the cohort studies). Statistical significance was defined as prevalence outside of a 95%-quantile interval of a bootstrap null distribution after random re-allocation of locations of infections. Results Prevalence of Plasmodium vivax and Plasmodium falciparum infections was elevated in close proximity around index infections and decreased with distance in most study sites, e.g. from 21.3% at 0 km to the global study prevalence of 6.4% for P. vivax in the Cambodian survey. In the cohort studies, the clustering decreased with longer time windows. The distance from index infections to a 50% reduction of prevalence ranged from 25 m to 3175 m, tending to shorter distances at lower global study prevalence. Conclusions The spatial signatures of P. vivax and P. falciparum infections demonstrate spatial clustering across a diverse set of study sites, quantifying the distance within which the clustering occurs. The method offers a novel tool in malaria epidemiology, potentially informing reactive intervention strategies regarding radius choices of operations around detected infections and thus strengthening malaria elimination endeavours.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The spatial signature of Plasmodium vivax and Plasmodium falciparum infections: quantifying the clustering of infections in cross-sectional surveys and cohort studies

Sandfort

Monteiro

Lacerda

et al. 2023

Malar J

Self Cite

View full text Add to dashboard Cite

show abstract

“…The other study took place in the peri-urban part of Manaus, Brazil, from April 2013 until March 2014 with 1,274 enrolled participants (47).…”

Section: Longitudinal Cohort Studiesmentioning

confidence: 99%

The spatial signature of Plasmodium vivax and P. falciparum infections: Quantifying the clustering of infections in cross-sectional surveys and cohort studies

Sandfort,

Monteiro,

Lacerda

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Background: Over the last decades, enormous successes have been achieved in reducing malaria burden globally. In Latin America, South East Asia, and the Western Pacific, many countries now pursue the goal of malaria elimination by 2030. It is widely acknowledged that Plasmodium spp. infections cluster spatially so that interventions need to be spatially informed, e.g. spatially targeted reactive case detection strategies. We introduce the spatial signature method as a tool to quantify the distance around an index infection within which other infections significantly cluster.Methods: We considered data from cross-sectional surveys from Brazil, Thailand, Cambodia, and Solomon Islands, conducted between 2012 and 2018. Household locations were recorded by GPS and finger-prick blood samples from participants were tested for Plasmodium infection by PCR. We also included cohort studies from Brazil and Thailand with monthly sampling over a year from 2013 until 2014. We calculated the prevalence of PCR-confirmed infections at increasing distance around index infections (and growing time intervals in the cohort studies). Statistical significance was defined as prevalence outside of a 95%-quantile interval of a bootstrap null distribution after random re-allocation of locations of infections.Results: Prevalence of Plasmodium vivax and P. falciparum infections was elevated in close proximity around index infections and decreased with distance in most study sites, e.g. from 21.3% at 0 km to the global study prevalence of 6.4% for P. vivax in the Cambodian survey. In the cohort studies, the clustering decreased with longer time windows. The distance from index infections to a 50% reduction of prevalence ranged from 25 m to 3,175 m, tending to shorter distances at lower global study prevalence. Conclusions: The spatial signatures of P. vivax and P. falciparum infections demonstrate spatial clustering across a diverse set of study sites, quantifying the distance within which the clustering occurs. The method offers a novel tool in malaria epidemiology, potentially informing reactive intervention strategies regarding radius choices of operations around detected infections and thus strengthening malaria elimination endeavours.

show abstract

Polymorphisms in Toll-Like receptors genes and their associations with immunological parameters in Plasmodium vivax malaria in the Brazil-French Guiana Border

et al. 2023

View full text Add to dashboard Cite

Prevalence and force of Plasmodium vivax blood-stage infection and associated clinical malaria burden in the Brazilian Amazon

Cited by 4 publications

References 31 publications

The spatial signature of Plasmodium vivax and Plasmodium falciparum infections: quantifying the clustering of infections in cross-sectional surveys and cohort studies

The spatial signature of Plasmodium vivax and Plasmodium falciparum infections: quantifying the clustering of infections in cross-sectional surveys and cohort studies

The spatial signature of Plasmodium vivax and P. falciparum infections: Quantifying the clustering of infections in cross-sectional surveys and cohort studies

Polymorphisms in Toll-Like receptors genes and their associations with immunological parameters in Plasmodium vivax malaria in the Brazil-French Guiana Border

Contact Info

Product

Resources

About