Epidemiology of paracoccidioidomycosis in Venezuela: a retrospective study from 1954 to 2019

Alvarado, Primavera; Teixeira, Marcus de Melo; Cavallera, Elsy; Paes, Hugo Costa; Guerra, Giovanni; Santander, Gerardo; Merino-Alado, Rommie

doi:10.1590/0074-02760210203

Cited by 7 publications

(2 citation statements)

References 41 publications

(56 reference statements)

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“…Paracoccidioides take an average of 3–6 weeks to grow on fungal culture media [ 88 , 89 , 90 ]. Nonetheless, the growth of this fungus varies in the different studies, with a sensitivity of 80 to 97% of cases [ 21 , 90 , 91 , 92 ]. The results should be evaluated about 4 weeks after the cultivation of the sample at 25 °C.…”

Section: Diagnosis Of Paracoccidioidomycosismentioning

confidence: 99%

Paracoccidioidomycosis: What We Know and What Is New in Epidemiology, Diagnosis, and Treatment

Peçanha

Peçanha-Pietrobom

Velloso

et al. 2022

JoF

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Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America caused by thermodimorphic fungi of the genus Paracoccidioides. In the last two decades, enhanced understanding of the phylogenetic species concept and molecular variations has led to changes in this genus’ taxonomic classification. Although the impact of the new species on clinical presentation and treatment remains unclear, they can influence diagnosis when serological methods are employed. Further, although the infection is usually acquired in rural areas, the symptoms may manifest years or decades later when the patient might be living in the city or even in another country outside the endemic region. Brazil accounts for 80% of PCM cases worldwide, and its incidence is rising in the northern part of the country (Amazon region), owing to new settlements and deforestation, whereas it is decreasing in the south, owing to agriculture mechanization and urbanization. Clusters of the acute/subacute form are also emerging in areas with major human intervention and climate change. Advances in diagnostic methods (molecular and immunological techniques and biomarkers) remain scarce, and even the reference center’s diagnostics are based mainly on direct microscopic examination. Classical imaging findings in the lungs include interstitial bilateral infiltrates, and eventually, enlargement or calcification of adrenals and intraparenchymal central nervous system lesions are also present. Besides itraconazole, cotrimoxazole, and amphotericin B, new azoles may be an alternative when the previous ones are not tolerated, although few studies have investigated their use in treating PCM.

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Section: Diagnosis Of Paracoccidioidomycosismentioning

confidence: 99%

Paracoccidioidomycosis: What We Know and What Is New in Epidemiology, Diagnosis, and Treatment

Peçanha

Peçanha-Pietrobom

Velloso

et al. 2022

JoF

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“…This disease is more prevalent in adult men who perform agricultural activities. Currently, there is an increasing number of cases in urban areas with a greater representation in females [2].…”

Section: Introductionmentioning

confidence: 99%

Paracoccidioidomycosis differential diagnosis: case series

Martins¹,

Silva²,

Ferreira³

et al. 2023

BJCR

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Paracoccidioidomycosis is a neglected disease and the most important systemic mycosis in Latin America. This fungal infection is directly linked to activities related to the rural environment, such as agriculture. Despite being a frequently diagnosed disease in Brazil, the real rates of prevalence and incidence are not estimated due to the non-mandatory notification of the disease, which was recently implemented in 2020. We report three interesting cases of Paracoccidioidomycosis in immunocompetent adults, with varied clinical manifestations.

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Micosis en pacientes inmunocomprometidos

Gutiérrez

2022

Medicine - Programa de Formación Médica Continuada Acreditado

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Epidemiology of paracoccidioidomycosis in Venezuela: a retrospective study from 1954 to 2019

Cited by 7 publications

References 41 publications

Paracoccidioidomycosis: What We Know and What Is New in Epidemiology, Diagnosis, and Treatment

Paracoccidioidomycosis: What We Know and What Is New in Epidemiology, Diagnosis, and Treatment

Paracoccidioidomycosis differential diagnosis: case series

Micosis en pacientes inmunocomprometidos

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