Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region

Martins, Rafael Affini; Cassu-Corsi, Dandara; Nodari, Carolina Silva; Cayô, Rodrigo; Natsumeda, Larissa; Streling, Ana Paula; Doi, André Mario; Silva, Roberto José Carvalho da; Bocalon, Roberta Alessandra Lima; Gales, Ana Cristina; Pignatari, Antônio Carlos Campos

doi:10.1590/0074-02760190079

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…The studies provided data on AMR in the following countries: Argentina ( n = 10) 29 , 45 , 48 , 52–54 , 63 , 66 , 67 , 70 during 1993 and between 2000 and 2017; Brazil ( n = 9) 42 , 44 , 46 , 47 , 50 , 55 , 57 , 58 , 65 in 2003 to 2016; Colombia ( n = 2) 43 , 61 in 2009 to 2018; Peru ( n = 6) 56 , 59 , 60 , 62 , 68 , 69 in 2012 to 2017; Uruguay ( n = 1) 41 in 2010 and 2011; and Venezuela ( n = 1) 51 during 2008. There were also two studies reporting on AMR in various LAC countries from the WHO-GASP-LAC, one of which 49 reported resistance between 1990 and 2011 in 23 LAC countries, and the other reported data from 2010 and 2011 in seven LAC countries.…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: a systematic review

Sandoval

Bardach

Rojas‐Roque

et al. 2023

Journal of Antimicrobial Chemotherapy

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Background Detailed information is needed on the dynamic pattern of antimicrobial resistance (AMR) in Neisseria gonorrhoeae in Latin America and the Caribbean (LAC). Objectives To conduct a systematic review of AMR in N. gonorrhoeae in LAC. Methods Electronic searches without language restrictions were conducted in PubMed, Embase, Cochrane Library, EconLIT, Cumulative Index of Nursing and Allied Health Literature, Centre for Reviews and Dissemination, and Latin American and Caribbean Literature in Health Sciences. Studies were eligible if published between 1 January 2011 and 13 February 2021, conducted in any LAC country (regardless of age, sex and population) and measured frequency and/or patterns of AMR to any antimicrobial in N. gonorrhoeae. The WHO Global Gonococcal Antimicrobial Surveillance Programme (WHO-GASP) for LAC countries and Latin American AMR Surveillance Network databases were searched. AMR study quality was evaluated according to WHO recommendations. Results AMR data for 38, 417 isolates collected in 1990–2018 were included from 31 publications, reporting data from Argentina, Brazil, Colombia, Peru, Uruguay, Venezuela and WHO-GASP. Resistance to extended-spectrum cephalosporins was infrequent (0.09%–8.5%). Resistance to azithromycin was up to 32% in the published studies and up to 61% in WHO-GASP. Resistance to penicillin, tetracycline and ciprofloxacin was high (17.6%–98%, 20.7%–90% and 5.9%–89%, respectively). Resistance to gentamicin was not reported, and resistance to spectinomycin was reported in one study. Conclusions This review provides data on resistance to azithromycin, potentially important given its use as first-line empirical treatment, and indicates the need for improved surveillance of gonococcal AMR in LAC. Trial registration: Registered in PROSPERO, CRD42021253342.

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Section: Resultsmentioning

confidence: 99%

Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: a systematic review

Sandoval

Bardach

Rojas‐Roque

et al. 2023

Journal of Antimicrobial Chemotherapy

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“…[8] Furthermore, Neisseria Gonorrhea is able to accumulate different mutations leading to the emergence of clinical isolates with clinically significant levels of resistance to currently or previously used antibiotics such as sulfadrugs, penicillins and tetracyclines which has led the WHO to consider adding N. Gonorrhea infections to the category of untreatable infections [9][10][11][12]. With the absence of effective vaccines, and the lack of prolonged immunity after infection due to multiple evading mechanisms, society relies on antibiotics to reduce the spread of the gonococcus in the community [6,13,14].…”

Section: Introductionmentioning

confidence: 99%

Immunoinformatics Prediction of an Epitope Based Peptide Vaccine for Neisseria Gonorrhea Dihydrolipoamide Acetyltransferase Protein

Elhag¹,

Sati²,

Abdelmoneim³

et al. 2021

Preprint

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Sexually transmitted infections (STIs) such as Gonorrhea is associated with serious morbidity and mortality rates in the world considering the multiple virulence factors possessed. The disease is manifested as salpingitis, pelvic inflammatory disease (PID), and bacteremia and is controlled by macrophages, dendritic cells, neutrophils, T cells, epithelial cells and cytokines. Dihydroliponamide acetyltransferase, a component of the mitochondrial pyruvate complex can be used as immunogenic target. Recent changes in the strain allowed the bacteria to acquire resistance against antibiotics.Vaccination remains an alternative to prevention against the disease. This study predicts an effective epitope-based vaccine against dihydrolipoamide acetyltransferase of Neisseria Gonorrhea using immunoinformatics approaches. Sequences retrieved from NCBI were passed on several prediction tests to analyze for possible B-cell, T-cell MHC class I epitopes and class II. Two epitopes showed high binding affinity for B-cells, while thirteen epitopes showed high binding affinity for MHCI and forty-five for MHCII. A population coverage of 100% for combined MHC I and II dictates the huge number of individuals who will benefit from formulating the vaccine. We recommend invivo and invitro studies to prove our prediction results.

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Genomic analyses of ciprofloxacin-resistant Neisseria gonorrhoeae isolates recovered from the largest South American metropolitan area

et al. 2022

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Temporal evolution of antimicrobial resistance among Neisseria gonorrhoeae clinical isolates in the most populated South American Metropolitan Region

Cited by 4 publications

References 11 publications

Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: a systematic review

Antimicrobial resistance of Neisseria gonorrhoeae in Latin American countries: a systematic review

Immunoinformatics Prediction of an Epitope Based Peptide Vaccine for Neisseria Gonorrhea Dihydrolipoamide Acetyltransferase Protein

Genomic analyses of ciprofloxacin-resistant Neisseria gonorrhoeae isolates recovered from the largest South American metropolitan area

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