Exposure source prevalence is associated with gender in hepatitis C virus patients from Rio de Janeiro, Brazil

Olmedo, Daniele B.; Precioso, Patrícia M.; Ludgero-Correia, Antonio; Silva, Guida da; Santos, Ângela; Pôrto, Luís Cristóvão

doi:10.1590/0074-02760160553

Cited by 7 publications

(7 citation statements)

References 17 publications

(29 reference statements)

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“…In this study, we conducted 30 secondary data in the form of medical records of chronic hepatitis C patients who had met the inclusion and exclusion criteria with a percentage of 13 males (43.3%) and 17 females (56.7%), with more female subjects. This result consistent with previous studies (Umumararungu et al, 2017;Olmedo et al, 2017). The transmission route of HCV infection in this study was mostly through family relationships, followed by a history of surgery, blood transfusions, and having tattoos.…”

Section: Discussionsupporting

confidence: 93%

Correlation Between HCV Rna Viral Load and Homa-Ir in Chronic Hepatitis C Patients

Allia¹,

Setiawan²,

Soelistijo³

2021

CIMRJ

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Background: Insulin resistance (IR) is one of the extrahepatic complications of hepatitis C virus (HCV) infection that needs to be recognized early. HOMA-IR is an effective way to measure insulin resistancy. Core proteins, NS-3, and NS-5 are the main components of HCV RNA proteins which are involved in the incidence of IR. Seeing this, a hypothesis was developed that the level of HCV RNA viral load was related to the HOMA-IR. This study was designed to identify the correlation between HCV RNA viral load with HOMA-IR in chronic hepatitis C patients.Method: We conducted a cross-sectional approach from the medical record of chronic hepatitis C patients at the outpatient clinic dr. Soetomo Hospital, Surabaya. A total of 30 patients aged >19 years old with complete medical records were included. Clinical and laboratory (including HCV RNA viral load level and HOMA-IR) data were obtained from the availability of medical records.Result: A total of 30 chronic hepatitis C patients, 17 (56.7%) were women and 13 (43.3%) were men, with mean age was 50.90 ± 7.17 years. The median of HCV RNA viral load level was 3,14 x106 IU/ml and the median of HOMA-IR was 4.50. The result of the Spearman correlation test showed a moderate positive association between HCV RNA viral load and HOMA-IR (r=0.537 ; p=0.002).Conclusion: A positive moderate correlation was obtained between HCV RNA viral load with HOMA-IR in chronic hepatitis C patients.

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Section: Discussionsupporting

confidence: 93%

Correlation Between HCV Rna Viral Load and Homa-Ir in Chronic Hepatitis C Patients

Allia¹,

Setiawan²,

Soelistijo³

2021

CIMRJ

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“…In this study, we observed an increasing trend in the detection rate in both sexes; however, there was a decrease in the male-to-female ratio due to a greater increase in the number of cases in women during the period analysed. This trend had already been observed in a previous study carried out in Rio de Janeiro, Brazil, which observed a decrease in the male-to-female ratio, from 1.2 to 0.9, in cases of HCV between the years 2008 and 2012 [ 21 ]. The increase in cases among women may reflect behavioural changes over the years, where women may have been more exposed to risk factors for infection.…”

Section: Discussionsupporting

confidence: 71%

“…In relation to sociodemographic characteristics, a higher incidence of HCV was observed in males. Higher prevalence of HCV in men is related to greater exposure to risk factors, such as the use of inhaled drugs, injected drugs, and sexual activity [ 20 , 21 ]. In this study, we observed an increasing trend in the detection rate in both sexes; however, there was a decrease in the male-to-female ratio due to a greater increase in the number of cases in women during the period analysed.…”

Section: Discussionmentioning

confidence: 99%

A time series analysis of detection and mortality of hepatitis C in Brazil, 2008–2018

et al. 2022

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Background The 69th World Health Assembly approved the Global Health Sector Strategy to eliminate hepatitis C virus (HCV) infection by 2030. In Brazil, efforts have been undertaken to achieve this goal; there are, however, great challenges. It is important to understand the disease profile in different regions of the country in order to design strategies to fight the disease nationwide. The objective of this study was to analyse the time trend of the incidence and mortality of hepatitis C in Brazil during the period from 2008 to 2018 according to sociodemographic and clinical characteristics. Methods All newly diagnosed cases of hepatitis C reported between 2008 and 2018, in all regions of Brazil, were included. The indicators were obtained from the databases of the Brazilian Ministry of Health. For the time series analysis, a joinpoint regression model was used. Results Between 2008 and 2018, 136,759 newly diagnosed cases of hepatitis C were reported considering anti-HCV and HCV RNA positivity, and 271,624 newly diagnosed cases were reported considering one or another positive test. The majority of the records were concentrated in the Southeast (61%) and South (26.2%) Regions. The joinpoint regression model indicated an increasing trend in the detection rate of hepatitis C in Brazil, but there was a decreasing trend in the mortality rate during the period analysed. Conclusions Differences were observed in the time trend of hepatitis C and in the sociodemographic and clinical characteristics in different regions of Brazil. These data can provide support to design strategies for the elimination of hepatitis C in Brazil, according to regional particularities.

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“…Although there was no significant difference between the both genders, but there was a higher number of females with the co infection than the male. This does not agree with the work done by Tremeau-Bravard et al 26 in Abuja in which the gender distribution was equal and in the findings of Hamza et al 27 in the north western part of Nigeria in which more males were infected than females but agrees with the report of Olmedo et al 28 in Rio de Janairo (Brazil) and Newton et al 29 in Ughelli. It is noted that females in the northern part of Nigeria are very conservative due to their religious beliefs which could be responsible for the low prevalence in the female gender than the male gender.…”

Section: Discussioncontrasting

confidence: 70%

Detection of hepatitis C virus among HIV patients in Port Harcourt, Rivers State

Baeka¹,

Oloke²,

Opaleye³

2021

Afr H. Sci.

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Background: Hepatitis C virus (HCV) a major human pathogen infecting millions of individuals worldwide, thereby in- creasing the risks for chronic liver diseases and has been discovered that HIV/HCV co-infected patients have a greater risk. Objective: To determine the prevalence of HCV infection among HIV infected people in Port Harcourt, Rivers State. Methodology: The patients were from the ages of 18 and above attending the antiretroviral clinic for over 6 months. The mean age of the participants was 36.91±8.38. Data were gotten from the 550 patients using a modified questionnaire and 5mls of blood samples were collected through venepuncture into EDTA bottles and spun at 3000rpm for 10 minutes sepa- rating the plasma from the whole blood. The CD4+ count was gotten from the patients’ file and the samples kept at -700C till analized. HCV antibody was detected using a commercially available third generation kit manufactured by Melsin Medical Co and statistical analysis was done using a Stata version 16. P value was determined using ANOVA. Result: Total number positive to the HCV antibody was 24(4.4%) of which 8(33.3%) were males, while 16(66.7%) were females. Prevalence (29.2%) was among patients in the 31–35 age range. The CD4+ count ranged from 22-864 cells/µl with a mean value of 303.08±194. Conclusion: From this study HIV/HCV co-infection occurs among HIV infected people in Port Harcourt. The CD4+ count was discovered to be low and was not age, nor gender dependent. HIV infected people should therefore be routinely screened for HCV. Keywords: Serology; HCV; HIV; CD4+ Count.

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Exposure source prevalence is associated with gender in hepatitis C virus patients from Rio de Janeiro, Brazil

Cited by 7 publications

References 17 publications

Correlation Between HCV Rna Viral Load and Homa-Ir in Chronic Hepatitis C Patients

Correlation Between HCV Rna Viral Load and Homa-Ir in Chronic Hepatitis C Patients

A time series analysis of detection and mortality of hepatitis C in Brazil, 2008–2018

Detection of hepatitis C virus among HIV patients in Port Harcourt, Rivers State

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