Influence of IL-6, IL-8, and TGF-β1 gene polymorphisms on the risk of human papillomavirus-infection in women from Pernambuco, Brazil

Júnior, Sérgio Ferreira de Lima; Tavares, Mayara; Macêdo, Jamilly Lopes de; Oliveira, Renata Santos de; Heráclio, Sandra de Andrade; Maia, Maria de Mascena Diniz; Souza, Paulo Roberto Eleutério de; Moura, Ronald; Crovella, Sérgio

doi:10.1590/0074-02760160051

Cited by 13 publications

(6 citation statements)

References 26 publications

(23 reference statements)

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“…The association of IL-6 -174G>C polymorphism with high HPV viral load was not detected. De Lima Júnioret et al showed no difference in the frequency of the -174G>C (rs 1800795) polymorphism in Brazilian women infected with HPV and uninfected controls ( 36 ) which is in agreement with our findings. At the same time, several studies reported a relationship between presences of -174C allele and low-level expression of IL-6 which led to an increase in the risk of cervical cancer ( 37 , 38 ).…”

Section: Discussionsupporting

confidence: 93%

Association Between Promoter Polymorphisms of IL-1Β, IL-4 and IL-6 Genes and a Viral Load Infected Women with Human Papillomavirus

Albosale¹,

Машкина²

2021

JRI

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Background: The purpose of this study was to investigate the association between IL-4 -589C>T, IL-6 -174G>C, IL-1β -31T>C and IL-1β -511C>T genes polymorphism with high concentrations of human papillomavirus (HPV), and the influence of gene-gene interactions on persistent human papillomavirus infection. Methods: In this study, 101 infected women with high HPV viral load and 93 healthy women were involved in a case-control study. Genotyping of SNPs for IL-4 -589C>T, IL-6 -174G>C, IL-1β -31T>C and IL-1β -511C>T genes was carried out by allele-specific PCR. Quantitative analysis of HPV-DNA was performed by Amplisens HPV HCR genotype-titer software. Gene-gene interactions were analyzed using multifactor dimensionality reduction (MDR) algorithm. Haplotype interactions were analyzed by HaploView 4.2 tool. Results: The study of single individual SNPs in promoters of IL-4 -589C>T, IL-6 -174G>C and IL-1β -31T>C genes did not reveal statistically significant difference in genotypesand allele frequencies among women with high HPV viral load and control group. The frequency of -511T allele and TT genotype of the IL-1β gene in case group was significantly higher than the one in control group (OR=1.71, p=0.012 and OR=2.02, p=0.046, respectively). Haplotype analysis revealed that -511C/-31T haplotype for IL-1β gene is significantly less common among women with high HPV viral load (p=0.018). Conclusion: The haplotype -511C/-31T for IL-1β gene is associated with a protective effect against increasing HPV viral load. The frequencies of -511T allele and -511TT genotype of the IL-1β -511C>T were significantly higher among women with HPV in comparison to control group.

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Section: Discussionsupporting

confidence: 93%

Association Between Promoter Polymorphisms of IL-1Β, IL-4 and IL-6 Genes and a Viral Load Infected Women with Human Papillomavirus

Albosale¹,

Машкина²

2021

JRI

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“…Junior's study data shows any significant association between the IL-6+174G>C polymorphism and HPV infected women or uninfected controls or between HSIL and LSIL subgroups. However, taking into account the fact that individuals from the control group could have been previously infected by HPV that was spontaneously eliminated, and based on findings, Junior and colleagues hypothesized that the IL-8 + 396 G allele and GG genotypes could play a role in the risk of HPV infection in a Brazilian study population [20].…”

Section: Discussionmentioning

confidence: 99%

IL-6 597A/G (rs1800797) and 174G/C (rs1800795) Gene Polymorphisms in the Development of Cervical Cancer in Lithuanian Women

et al. 2021

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Our study aimed to evaluate the distribution of genotypes and allele frequencies of IL-6 597A/G (rs1800797) and 174G/C (rs1800795) polymorphisms in HPV infected and uninfected healthy women and cervical cancer patients. A PCR based Multiplex HPV genotyping test kit was used for in vitro detection and differentiation of high risk HPV genotypes. Genotyping of two polymorphisms, IL-6 597A/G (rs1800797) and 174G/C (rs1800795), was performed using the KASP genotyping assay kit. Cervical cancer patients were more likely to be HPV positive than control patients. Allele C of IL-6 rs1800795 was associated with a higher risk of cervical cancer by 2.26-fold and genotype CC by 5.37-fold. Genotype CC of IL-6 rs1800795 was more frequent in the HPV positive group compared with the HPV negative group (p = 0.002). Allele G of IL-6 rs1800797 was more frequently found in women with HPV16/HPV18 compared to other HPV types (p = 0.045). Women with AA genotypes of IL-6 rs1800797 were less frequently infected with HPV16/HPV18 compared to other HPV types (p = 0.045). The major finding of the study is the significant association of C allele and CC genotype of IL-6 1800795 gene with cervical cancer in the Lithuanian population. Genotype CC of IL-6 rs1800795 has a significant association with HPV infection as well.

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“…In this meta-analysis different case-control groups or cohorts in one publication were considered as independent total of 59 studies were included in this meta-analysis. There are seven studies with 1112 cases and 1233 controls on XRCC3 rs861539 (He et al, 2008;Xiao, 2009;Settheetham-Ishida et al, 2011;Djansugurova et al, 2013;Pérez et al, 2013;Al-Harbi et al, 2017), 14 studies with 2694 cases and 3349 controls MTHFR rs1801133 (Lambropoulos et al, 2003;Sull et al, 2004;Kang et al, 2005;Zoodsma et al, 2005;Delgado-Enciso et al, 2006;Ma et al, 2006;Nandan et al, 2008;Shekari et al, 2008;Kohaar et al, 2010;Yang et al, 2011;Prasad and Wilkhoo, 2011;Tong et al, 2011;Mostowska et al, 2011;von Keyserling et al, 2011), four studies with 1121 cases and 1109 controls on IL-12B rs3212227 (Chen et al, 2009;Do Carmo Vasconcelos De Carvalho et al, 2012;Roszak, Mostowska, et al, 2012), seven studies with 1452 cases and 2186 controls on IL-6 rs1800795 (Nogueira De Souza et al, 2006;Gangwar et al, 2009;Grimm et al, 2011;Shi et al, 2013;de Lima Júnior et al, 2016;Pu et al, 2016;Zidi et al, 2017), 20 studies with 4,781 cases and 4909 controls on TNF-α rs1800629 (Stanczuk et al, 2019;Jang et al, 2001;Calhoun et al, 2002;Gostout et al, 2003;…”

Section: Data Extractionmentioning

confidence: 99%

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

Parsaeian

Asadian

Karimi-Zarchi

et al. 2021

Asian Pac J Cancer Prev

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Background:In spite of substantial declines in both incidence and mortality rates in the past 50 years, cervical cancer remains one of the leading causes of cancer associated mortality among women globally. We performed this meta-analysis to explore the role of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629 and TLR9 rs352140 polymorphism with susceptibility to cervical carcinoma. Methods: The search databases include PubMed, SciELO, MedRxiv, Web of Science, Scopus, Cochrane Library, China National Knowledge Infrastructure, and China Biology Medicine disc up to 30 June 2021. The language is limited to English and Chinese. The comparison between the polymorphisms and cervical cancer was assessed using pooled odds ratio (OR) and 95% confidence interval (CI). The data are statistically analyzed by Comprehensive Meta-Analysis (CMA) 2.0 software. Results: A total of 59 studies including seven studies with 1,112 cases and 1,233 controls on XRCC3 rs861539, 14 studies with 2,694 cases and 3349 controls MTHFR rs1801133, four studies with 1,121 cases and 1,109 controls on IL-12B rs3212227, seven studies with 1,452 cases and 2,186 controls on IL-6 rs1800795, 20 studies with 4,781 cases and 4909 controls on TNF-α rs1800629, and seven studies with 1743 cases and 2292 controls on TLR9 rs352140 were included. There was a significant association between XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 polymorphisms and an increased risk of cervical carcinoma in overall population. However, the MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms were not associated. Conclusion: The pooled analysis showed that XRCC3 RS861539, TNF-α rs1800629, and IL-6 rs1800795 were associated with cervical carcinoma susceptibility, but not MTHFR rs1801133, IL-12B rs3212227 and TLR9 rs352140 polymorphisms.

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Influence of IL-6, IL-8, and TGF-β1 gene polymorphisms on the risk of human papillomavirus-infection in women from Pernambuco, Brazil

Cited by 13 publications

References 26 publications

Association Between Promoter Polymorphisms of IL-1Β, IL-4 and IL-6 Genes and a Viral Load Infected Women with Human Papillomavirus

Association Between Promoter Polymorphisms of IL-1Β, IL-4 and IL-6 Genes and a Viral Load Infected Women with Human Papillomavirus

IL-6 597A/G (rs1800797) and 174G/C (rs1800795) Gene Polymorphisms in the Development of Cervical Cancer in Lithuanian Women

A Meta-Analysis for Association of XRCC3 rs861539, MTHFR rs1801133, IL-6 rs1800795, IL-12B rs3212227, TNF-α rs1800629, and TLR9 rs352140 Polymorphisms with Susceptibility to Cervical Carcinoma

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