Experimental infection of Rio Mamore hantavirus in Sigmodontinae rodents

Abstract

This study shows an experimental spillover infection ofSigmodontinae rodents with Rio Mamore hantavirus (RIOMV).Necromys lasiurus and Akodon sp were infected with 103 RNA copies of RIOMV by intraperitoneal administration. The viral genome was detected in heart, lung, and kidney tissues 18 days after infection (ai), and viral excretion in urine and faeces began at four and six ai, respectively. These results reveal that urine and faeces of infected rodents contain the virus for at least 18 days. It is possible that inhaled aerosols of these excreta could transmit hantavirus to humans and other animals.

The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future

“…As such, McGuire et al [54] have shown that Maporal virus (MAPV), a South American hantavirus whose reservoir is the delicate pigmy rice ( Oligoryzomys delicates ), was able to infect deer mice in laboratory conditions. Similarly, de Souza et al [55] have revealed experimentally that Rio Mamore virus (RIOMV), another south American hantavirus naturally infecting Oligoryzomys microtis , was able to infect other Sigmodontinae rodents ( Necromys lasiurus and Akodon sp. ).…”