Phylogenetic analyses of chikungunya virus among travelers in Rio de Janeiro, Brazil, 2014-2015

Conteville, Liliane Costa; Zanella, Louise; Abanto, Michel; Filippis, Ana María Bispo de; Nogueira, Rita Maria Ribeiro; Vicente, Ana Carolina Paulo; Mendonça, Marcos César Lima de

doi:10.1590/0074-02760160004

Cited by 20 publications

(18 citation statements)

References 7 publications

(7 reference statements)

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“…Recent sequences show that the ECSA lineage continued to circulate in the state of Bahia as of July 2015 and spread south to the state of Pernambuco in March 2016. On the other hand, an American strain caused the first autochthonous transmission in the state of Rio de Janeiro in December 2015 (69). Our phylogenetic trees (Fig.…”

Section: Discussionmentioning

confidence: 92%

Comprehensive Genome Scale Phylogenetic Study Provides New Insights on the Global Expansion of Chikungunya Virus

Chen

Puri

Fedorova

et al. 2016

J Virol

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Since the India and Indian Ocean outbreaks of 2005 and 2006, the global distribution of chikungunya virus (CHIKV) and the locations of epidemics have dramatically shifted. First, the Indian Ocean lineage (IOL) caused sustained epidemics in India and has radiated to many other countries. Second, the Asian lineage has caused frequent outbreaks in the Pacific islands and in 2013 was introduced into the Caribbean, followed by rapid spread to nearly all of the neotropics. Further, CHIKV epidemics, as well as exported cases, have been reported in central Africa after a long period of perceived silence. To understand these changes and to anticipate the future of the virus, the exact distribution, genetic diversity, transmission routes, and future epidemic potential of CHIKV require further assessment. To do so, we conducted the most comprehensive phylogenetic analysis to date, examined CHIKV evolution and transmission, and explored distinct genetic factors associated with the emergence of the East/Central/ South African (ECSA) lineage, the IOL, and the Asian lineage. Our results reveal contrasting evolutionary patterns among the lineages, with growing genetic diversities observed in each, and suggest that CHIKV will continue to be a major public health threat with the potential for further emergence and spread. IMPORTANCE Chikungunya fever is a reemerging infectious disease that is transmitted by

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Section: Discussionmentioning

confidence: 92%

Comprehensive Genome Scale Phylogenetic Study Provides New Insights on the Global Expansion of Chikungunya Virus

Chen

Puri

Fedorova

et al. 2016

J Virol

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“…aegypti in Brazil are restricted to few groups. The available data about CHIKV circulation are obtained from the human cases that show, until now, the circulation of the Asian genotype, in the Northern (state of Amapá [15]) and Southeast (Rio de Janeiro [91,92]) regions, and the ECSA genotype, reported in the Northern (Amazônia [93]), Northeast (Alagoas [88,89], Bahia [15,88,90], Paraíba [88], and Sergipe [90]), and Southeast (in Rio de Janeiro [90,94] and Minas Gerais [95]).…”

Section: Discussionmentioning

confidence: 99%

Natural Infection of Aedes aegypti by Chikungunya and Dengue type 2 Virus in a Transition Area of North-Northeast Brazil

Aragão

Pinheiro

Neto

et al. 2019

Viruses

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Dengue fever, chikungunya, and Zika are diseases caused by viruses transmitted by Aedes aegypti and Aedes albopictus. In Brazil, the number of human infections is high, but few studies are performed in mosquito vectors. This study aimed to investigate the presence of Zika, Dengue and Chikungunya viruses in Ae. aegypti and Ae. albopictus from the municipalities of Alto Alegre, Caxias, Codó, and São Mateus do Maranhão, located in the state of Maranhão, Northeast Brazil. The mosquitoes were collected with a mechanical aspirator, identified, triturated, and then submitted to RNA extraction and RT-qPCR. The positive samples were confirmed by virus isolation and genome sequencing. Three hundred and forty-eight Ae. aegypti (176 males and 172 females) and 12 Ae. albopictus (eight males and four females) were collected and tested. Ae. aegypti was the only vector positive in two municipalities—Codó, with detection of Chikungunya virus (CHIKV) belonging to the East-Central-South African genotype, and in Caxias, with detection of Dengue virus (DENV)-2 belonging to the Asian/American genotype. The detection of CHIKV and DENV-2 is evidence that those viruses are maintained in arthropod vectors, and shows the epidemiological risk in the area for chikungunya cases and a possible increase of severe dengue cases, associated with the occurrence of dengue hemorrhagic fever.

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“…In September 2014, the Asian genotype reported in the Caribbean was detected in Amapá state, and the ECSA, which was never detected in the Americas, was confirmed in Bahia state. Since the first detection, more than 25,000 suspected cases of CHIKV infection have been registered in Brazil 81, 82…”

Section: Alphavirusmentioning

confidence: 99%

Mosquito-transmitted viruses – the great Brazilian challenge

Mota

Terzian

Silva

et al. 2016

Brazilian Journal of Microbiology

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Arboviruses pose a serious threat to public health worldwide, overloading the healthcare system and causing economic losses. These viruses form a very diverse group, and in Brazil, arboviruses belonging to the families Flaviviridae and Togaviridae are predominant. Unfortunately, the number of arboviruses increases in proportion with factors such as deforestation, poor sanitation, climate changes, and introduction of new viruses like Chikungunya virus and Zika virus.In Brazil, dengue is endemic, along with the presence of other arboviruses. The situation is complicated by the scarcity of diagnostic infrastructure and the absence of approved vaccines for these diseases. Disease control, thus, relies solely on vector control. Therefore, enhanced clinical knowledge and improved general awareness about these arboviruses are indispensable to tackle diagnostic inadequacies.

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Phylogenetic analyses of chikungunya virus among travelers in Rio de Janeiro, Brazil, 2014-2015

Cited by 20 publications

References 7 publications

Comprehensive Genome Scale Phylogenetic Study Provides New Insights on the Global Expansion of Chikungunya Virus

Comprehensive Genome Scale Phylogenetic Study Provides New Insights on the Global Expansion of Chikungunya Virus

Natural Infection of Aedes aegypti by Chikungunya and Dengue type 2 Virus in a Transition Area of North-Northeast Brazil

Mosquito-transmitted viruses – the great Brazilian challenge

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