Impact of concurrent epidemics of dengue, chikungunya, zika, and COVID-19

Vicente, Creuza Rachel; Silva, Theresa Cristina Cardoso da; Pereira, Larissa Dell'Antonio; Miranda, Angélica Espinosa

doi:10.1590/0037-8682-0837-2020

Cited by 20 publications

(23 citation statements)

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“…16 Coinfections were not reported during the concurrent outbreaks of SARS-CoV-2, CHIKV, DENV, and ZIKV in Esp ırito Santo State, Brazil, in 2020. 18 In conclusion, we report apparent concurrent and close sequential infections between SARS-CoV-2 and select arboviruses in Guerrero, Mexico. SARS-CoV-2 and the arboviruses under investigation produce overlapping clinical manifestations (i.e., fever, headache, fatigue, and myalgia), complicating the diagnosis of coinfections.…”

mentioning

confidence: 61%

Evidence of Coinfections between SARS-CoV-2 and Select Arboviruses in Guerrero, Mexico, 2020–2021

Núñez-Avellaneda

Villagómez

Villegas-Pineda

et al. 2022

The American Journal of Tropical Medicine and Hygiene

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We provide evidence of concurrent and close sequential infections between SARS-CoV-2 and select arboviruses—namely, chikungunya virus (CHIKV); dengue viruses 1, 2, and 3 (DENV1–3), and Zika virus (ZIKV)—in patients in Guerrero, southwest Mexico, in 2020–2021. The study population consisted of 176 febrile patients with laboratory evidence of SARS-CoV-2 infection. Sera from all patients were serologically and antigenically tested for seven arboviruses known to occur in Guerrero. Eighteen patients contained CHIKV IgM, six of whom also contained CHIKV RNA. Another 16 patients contained flavivirus antigen. The flaviviruses responsible for the infections were identified by plaque reduction neutralization test as DENV1 (two patients), DENV2 (five patients), DENV3 (three patients), ZIKV (three patients), and an undetermined flavivirus (three patients). In summary, we identified patients in Guerrero, Mexico, with concurrent or recent sequential infections between SARS-CoV-2 and select arboviruses, exemplifying the importance of performing differential diagnosis in regions where these viruses cocirculate.

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confidence: 61%

Evidence of Coinfections between SARS-CoV-2 and Select Arboviruses in Guerrero, Mexico, 2020–2021

Núñez-Avellaneda

Villagómez

Villegas-Pineda

et al. 2022

The American Journal of Tropical Medicine and Hygiene

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“…Earlier differentiation of patients with dengue or COVID-19 based on routine laboratory changes will give its widespread COVID-19 concurrence with other infectious diseases, such as dengue, that can occur especially in subtropical and tropical regions where dengue disease is highly prevalent [4,5]. Due to the tropical climate and the spread of SARS-CoV-2 in Mexico and other endemic areas, individuals are at risk for coinfection with dengue.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical sample collection, processing, and SARS-CoV-2 testing for all patients were based on WHO guidelines [2]. COVID-19 patients who met any of the following criteria were excluded from the study: (1) patients with previous DENV infection or other flaviviruses; (2) individuals with SARS-CoV-2/DENV coinfection; (3) patients aged ≤ 18 years; (4) pregnant patients; (5) patients with chronic renal dysfunction, malignant tumor, liver cirrhosis, acquired immune deficiency, and other autoimmune and inflammatory diseases. The Institutional Ethics and Research Committee approved the study at the Culiacan General Hospital, Sinaloa, Mexico.…”

Section: Study Design and Participantsmentioning

confidence: 99%

“…COVID-19 is classified according to the severity of the symptoms: mild, moderate, severe, and critical, leading to death [2]. Nowadays, the COVID-19 pandemic continues to spread worldwide, including subtropical and tropical regions where endemic diseases, such as dengue, are part of continuing public health surveillance [3][4][5]. Dengue virus (DENV) is the etiological agent of dengue disease classified into non-severe and severe dengue, with fatal complications in the severe cases [3].…”

Section: Introductionmentioning

confidence: 99%

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The Usefulness of Peripheral Blood Cell Counts to Distinguish COVID-19 from Dengue during Acute Infection

et al. 2022

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COVID-19 and dengue disease are challenging to tell apart because they have similarities in clinical and laboratory features during the acute phase of infection, leading to misdiagnosis and delayed treatment. The present study evaluated peripheral blood cell count accuracy to distinguish COVID-19 non-critical patients from non-severe dengue cases between the second and eleventh day after symptom onset. A total of 288 patients infected with SARS-CoV-2 (n = 105) or dengue virus (n = 183) were included in this study. Neutrophil, platelet, and lymphocyte counts were used to calculate the neutrophil–lymphocyte ratio (NLR), the platelet–lymphocyte ratio (PLR), and the neutrophil–lymphocyte*platelet ratio (NLPR). The logistic regression and ROC curves analysis revealed that neutrophil and platelet counts, NLR, LPR, and NLPR were higher in COVID-19 than dengue. The multivariate predictive model showed that the neutrophils, platelets, and NLPR were independently associated with COVID-19 with a good fit predictive value (p = 0.1041). The neutrophil (AUC = 0.95, 95% CI = 0.84–0.91), platelet (AUC = 0.89, 95% CI = 0.85–0.93) counts, and NLR (AUC = 0.88, 95% CI = 0.84–0.91) were able to discriminate COVID-19 from dengue with high sensitivity and specificity values (above 80%). Finally, based on predicted probabilities on combining neutrophils and platelets with NLR or NLPR, the adjusted AUC was 0.97 (95% CI = 0.94–0.98) to differentiate COVID-19 from dengue during the acute phase of infection with outstanding accuracy. These findings might suggest that the neutrophil, platelet counts, and NLR or NLPR provide a quick and cost-effective way to distinguish between dengue and COVID-19 in the context of co-epidemics in low-income tropical regions.

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“…A coocorrência das patologias introduziu carga significativa de pacientes suspeitos no sistema de saúde, o qual enfrentou desafios em suas diferentes áreas de serviço, como a atenção primária, unidades de pronto-atendimento e hospitais, além dos sistemas de vigilância epidemiológica. No estado do Espírito Santo, por exemplo, um estudo mostrou que muitos dos casos notificados para covid-19 foram avaliados exclusivamente por critérios clínico-epidemiológicos em razão da limitação laboratorial para a realização de RT-PCR (VICENTE, 2021). A alta demanda por internação hospitalar, inclusive, levou ao esgotamento da oferta de leitos e ventiladores pulmonares em diversas regiões do país (MOREIRA, 2020).…”

Section: Discussionunclassified

Atualizações Em Doenças Tropicais Negligenciadas

2022

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IntroduçãoA Dengue é um problema signifi cativo para saúde pública no Brasil e no mundo. O país enfrenta epidemias de dengue desde 1986, sendo no período sazonal de março a junho. Seu principal transmissor é o mosquito, Aedes aegypti. (BARROSO, 2020).A dengue é uma doença encontrada em climas tropicais e subtropicais ao redor do mundo, principalmente em áreas urbanas e semiurbanas. Entre as patologias que mais afetam os países da América Latina, a dengue é uma das que mais afetam, principalmente devido aos condicionantes e determinantes de saúde ser precários nos países em desenvolvimento (BARROSO, et al., 2020) Apesar de possuir indicador de mortalidade baixa, essa doença possui um potencial de infectividade consideravelmente alto.O COVID-19 consiste em uma patologia altamente transmissível, que pode ser através do contato direto ou indireto com pessoas conta-BRASIL. Painel Coronavírus. (2020). Secretaria de Vigilância em Saúde. Disponível em: . Acesso em: 20 out 2021.

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Impact of concurrent epidemics of dengue, chikungunya, zika, and COVID-19

Abstract: Introduction: This study evaluated the epidemiological implications of arbovirus infections and coronavirus disease (COVID-19) cooccurrences in Espírito Santo, Brazil. Methods:

Cited by 20 publications

References 10 publications

Evidence of Coinfections between SARS-CoV-2 and Select Arboviruses in Guerrero, Mexico, 2020–2021

Evidence of Coinfections between SARS-CoV-2 and Select Arboviruses in Guerrero, Mexico, 2020–2021

The Usefulness of Peripheral Blood Cell Counts to Distinguish COVID-19 from Dengue during Acute Infection

Atualizações Em Doenças Tropicais Negligenciadas

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