Screening of synthetic 1,2,3-triazolic compounds inspired by SRPIN340 as anti-Trypanosoma cruzi agents
Fernanda Karoline Vieira da Silva Torchelsen,
Tamiles Caroline Pedrosa Fernandes,
Sara Maria Ribeiro de Sousa
et al.
Abstract:Background:
The current treatments for Chagas disease (CD) include benznidazole and
nifurtimox, which have limited efficacy and cause numerous side effects.
Triazoles are candidates for new CD treatments due to their ability to
eliminate
T. cruzi
parasites by inhibiting ergosterol
synthesis, thereby damaging the cell membranes of the parasite.
Methods:
Eleven synthetic analogs of the kinase inhibitor SRPIN340 containing a
triazole core (compou… Show more
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