Hepatitis B: Prevalence and occult infection in HIV-infected patients

Calux, Samira Julien; Silva, Vanessa Cristina Martins; Compri, Adriana Parise; Lemos, Marcílio Figueiredo; Santos, Ana Paula de Torres; Oba, Isabel Takano; Mendes-Corrêa, Maria Cássia; Moreira, Regina Célia

doi:10.1590/0037-8682-0533-2018

Cited by 7 publications

(11 citation statements)

References 11 publications

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“…It has been reported that the prevalence of OHBI in HIV‐infected individuals varies widely from 0% to 89.5% 9 . One of the reasons for the difference in the prevalence of OHB infection is the use of diagnostic methods with different sensitivity and specificity 1 . In our cohort, the frequency of OHB in 279 patients was found to be 1.4%.…”

Section: Discussionmentioning

confidence: 62%

“…Amongst the causes of HBsAg negativity, decrease or absence of HBsAg expression, decrease of HBsAg secretion from hepatocytes, and change of HBs antigenicity can be counted. The presence of mutations in the HBV genome, particularly the envelope gene, is an important cause of HBsAg negativity 1,8 …”

Section: Discussionmentioning

confidence: 99%

“…Acute and chronic HBV infection causes approximately 887 thousand deaths annually. However, when compared with HBV mono‐infection, the mortality and morbidity of HIV and HBV coexistence are higher 1 …”

Section: Introductionmentioning

confidence: 99%

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Occult hepatitis B infection in Turkish HIV‐infected patients: A multicentre, retrospective, cross‐sectional study, Schindler study

et al. 2021

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Objective Occult hepatitis B infection (OHBI) appears to have a higher prevalence in populations at high risk for hepatitis B virus (HBV) infection with concomitant liver disease. The aim was to assess the prevalence of OHBI in a sample of human immunodeficiency virus −1 positive and HBV surface antigen‐negative (HIV‐1+/HBsAg‐) Turkish patients. Methods Ten centres in Turkey were included in the study. Patients were selected on the basis of a power calculation with a known population size of HIV‐positive patients and a reported prevalence of OHBI. Gender, age, occupation, place of residence, treatment and clinical status, and laboratory results, including immunodeficiency panel, antibody tests, hemogram, biochemistry, and coagulation studies were evaluated retrospectively. Results The number of HIV‐infected patients followed in these centres was 3172 and the sample population numbered 278. All 278 were HBsAg negative. The mean age of the sample was 37.2 ± 13.1 years and 235 (84.5%) were male. All but one patient (99.6%) had been treated with antiretroviral therapy. Of the 278 patients, 169 (60.6%) were positive for Anti‐HBs and 125 (44.8%) were positive for Anti‐HBc IgG. HIV RNA was detected in 203/278 (73%) of the patients. Four HBV DNA (1.4%) were diagnosed with OHBI. There was no significant difference in hemogram, hemoglobin or bilirubin concentrations in those with OHBI compared with the other patients. Conclusion In a representative sample of HIV+ patients from 10 Turkish centres, the prevalence of OHBI was found to be 1.4%. In HIV positive patients, it is important to identify those with OHBI for optimal clinical management and prognosis.

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Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 99%

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Occult hepatitis B infection in Turkish HIV‐infected patients: A multicentre, retrospective, cross‐sectional study, Schindler study

et al. 2021

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“…Acute and chronic HBV infection causes approximately 887 thousand deaths annually. However, when compared with HBV monoinfection, the mortality and morbidity of HIV and HBV coexistence is higher (1).…”

Section: Introductionmentioning

confidence: 99%

“…Among the causes of HBsAg negativity, decrease or absence of HBsAg expression, decrease of HBsAg secretion from hepatocytes, change of HBsAg antigenicity can be counted. The presence of mutations in the HBV genome, particularly the envelope gene, is an important cause of HBsAg negativity(1,8).…”

mentioning

confidence: 99%

Research of Occult Hepatitis B Infection in HIV-infected Patients, Schindler Study

Ünlü¹,

Yıldız

Ören³

et al. 2021

Preprint

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Research of Occult Hepatitis B Infection in HIV-infected Patients, Schindler Study ABSTRACT Objective: Occult hepatitis B infection seems to be more prevalent among subjects at high risk for HBV infection and with concomitant liver disease. The aim of this study was to assess the prevalence of OHBI in group of HIV-1+/HBsAg- Turkish patients. Methods: Ten centers in Turkey have been included in the study. Gender, age, occupation, place of residence, treatment status, clinic, immunodeficiency panel, eliza tests, hemogram, biochemistry and coagulation laboratory results of the patients were evaluated retrospectively. Results: The number of HIV-infected patients followed in these centers is 3172. The mean age of the patients was 37.2 ± 13.1, and they were 235 males (84.5%) and 43 (15.5%) females. 278 (99.6%) of the patients are patients who received antiretroviral treatment. included in the s Of the 279 patients included in the study, it was determined that HBsAg was negative in all of them, 169 were positive for Anti HBs and 125 were positive for Anti HBc IgG. HIV RNA (203/278) was detected in 203 of the patients. 4 (1.4%) of the patients were diagnosed with OHB. In our study, no significant difference was found in hemoglobin and bilirubin levels and complete blood count in patients with HIV-OHB co-infection. However, albumin values were found to be <3.5 in three OHD patients (p = 0.043). Conclusion: Reasearch the presence of OHB infection in HIV-infected patients is important in determining treatment options and predicting the survival of patient. Hypoalbuminemia could be showing hepatic failure and we can suggest the importance of treatment that diseases.

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Occult Hepatitis B virus (HBV) infection and challenges for hepatitis elimination: A literature review

Almeida

Paula

2022

Journal of Applied Microbiology

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Occult hepatitis B infection (OBI) is characterized by the detection of hepatitis B virus (HBV) DNA in serum or liver but negativity for hepatitis B surface antigen. OBI, which is thought to be maintained by host, immunological, viral and/or epigenetic factors, is one of the most challenging clinical features in the study of viral hepatitis. Currently, there is no validated detection test for OBI. It is believed that OBI is widely distributed throughout the world, with a higher prevalence in populations at high-risk HBV, but the detailed worldwide prevalence patterns are unknown. We conducted a survey of recently published studies on OBI rates across all continents.High prevalence rates of OBI are observed in some specific groups, including patients with hepatitis C virus, human immunodeficiency virus co-infection or hepatocellular carcinoma. In 2016, the World Health Organization adopted strategies to eliminate viral hepatitis by 2030, but the difficulties in detecting and treating OBI currently challenge this goal. Subjects with OBI can transmit HBV, and episodes of reactivation can occur. Further studies to understanding the mechanisms that drive the development of OBI are needed and can contribute to efforts at eliminating viral hepatitis.

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Hepatitis B: Prevalence and occult infection in HIV-infected patients

Cited by 7 publications

References 11 publications

Occult hepatitis B infection in Turkish HIV‐infected patients: A multicentre, retrospective, cross‐sectional study, Schindler study

Occult hepatitis B infection in Turkish HIV‐infected patients: A multicentre, retrospective, cross‐sectional study, Schindler study

Research of Occult Hepatitis B Infection in HIV-infected Patients, Schindler Study

Occult Hepatitis B virus (HBV) infection and challenges for hepatitis elimination: A literature review

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